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Erythromycin - ClinicalTrials.gov

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Last Updated: 05 September 2022

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TREAT: Treatment of ppROM With Erythromycin vs. Azithromycin Trial

According to the American College of Obstetrics and Gynecology, the new care for PPROM subjects between 24 weeks and 6 days, is to administer ampicillin 2 gm IV every 6 hours for 48 hours, followed by amoxicillin 250 mg orally every 8 hours for 5 days. Erythromycin can cause GI upset, and some people are unable to adhere to this regimen for more than seven days. The benefits of azithromycin include: It is taken once or twice compared to erythromycin and erythromycin. Despite its widespread use, there is no evidence that azithromycin is equivalent to erythromycin on a scale 1. In 2014, Haas and colleagues published a retrospective comparison of the two regimens, finding that the switch of azithromycin for erythromycin in the recommended antibiotic regimen had no effect on latency or other reported maternal or fetal outcomes. The percentage of women still pregnant by day 7 after the diagnosis of PPROM is made would be the investigators' primary outcome. There is no such difference in the primary result between the group exposed to the azithromycin therapy regimen and the one that was not randomized to the erythromycin regimen, according to the investigators' working hypothesis.

Source link: https://clinicaltrials.gov/ct2/show/NCT03060473

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions