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Erythema Nodosum - Europe PMC

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Last Updated: 13 August 2022

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A real-world study of low-dose thalidomide in severe erythema nodosum leprosum highlighting its mechanistic rationale in a resource-constrained target population.

ENL patients were recruited over a 1-year span, according to the study's Methods. With a decreasing dose of prednisolone, an increasing dose of low-dose thalidomide was titrated depending on disease severity. Sixteen patients of ENL were investigated, and the majority of them were on steroids for a mean duration of 11. 27 months. Patients in the majority of patients within 3 months may be tapered with a small dose of thalidomide, which resulted in a significant reduction in prednisolone doses. By 3. 03 months, 92% of patients' survival rate had been stopped, and both drugs could be outlawed in 80% of cases by 5. 83 months. Conclusion: ENL with low-dose thalidomide regiments' historical efficacy in our series is similar to high-dose thalidomide regimens', making it an affordable therapy in resource-constrained settings and a good steroid-sparing agent.

Source link: https://europepmc.org/article/MED/35924464


Pembrolizumab-associated erythema nodosum in the treatment of metastatic melanoma.

Pembrolizumab for metastatic melanoma was found on her shins and forearms with tender red nodules. Subsequent investigations revealed bihilar lymphadenopathy, biopsied as granulomatous lymphadenitis, confirming the diagnosis of pembrolizumab-associated sarcoidosis. Immunotherapy-related sarcoidosis is a rare but well-known adverse event related to immunotherapy with immune checkpoint inhibitors. In the context of immunotherapy, immunotherapy-associated sarcoidosis and metastatic progression should be prompted by a prompt histological examination to distinguish between immunotherapy-associated sarcoidosis and metastatic progression.

Source link: https://europepmc.org/article/MED/35892257


Regulatory T cells in erythema nodosum leprosum maintain anti-inflammatory function.

We investigated Tregs' suppressive function in participants with LL and ENL's peripheral blood mononuclear cells by analyzing TNF, IFN, and IL-10 responses to Mycobacterium leprae stimulation before and after depletion of CD25+ cells. 30 LL participants with ENL and 30 LL participants without ENL were recruited, as well as 30 LL participants without ENL. TNF, IFN-u03b1 and IFN-u03b3 responses to M. leprae stimulation were boosted after and after 24 weeks of LL therapy with MDT and ENL with prednisolone, as shown by the depletion of CD25+ cells from PBMCs. Before and after 24 weeks of MDT in participants with LL, the Depleting CD25+ cells did not influence the IL-10 response to M. leprae. However, depletion of CD25+ cells was associated with an enhanced IL-10 response on stimulation with M. leprae in untreated participants with ENL, as well as reduced IL-10 responses in treated individuals with ENL. Conclusion M. leprae antigen specific and resistant response in people with LL can be reversed by depleting CD25+ cells, according to the results. The results support the belief that the impaired cell-mediated immune response in individuals with LL is M. leprae antigen specific, and the unresponsiveness can be reversed. Following the depletion of CD25+ cells in individuals with LL and untreated ENL, the underlying mechanism of immune regulation by Tregs in leprosy seems to be independent of IL-10 or that other cells may be responsible for IL-10 production in leprosy, according to the lack of correlation between IL-10 and CD25+ depleted PBMCs and CD25+ leprosy.

Source link: https://europepmc.org/article/MED/35867720

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions