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Epilepsy Treatment - Wiley Online Library

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Last Updated: 01 September 2022

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Cu‐Zn SOD suppresses epilepsy in pilocarpine‐treated rats and alters SCN2A/Nrf2/HO‐1 expression

Epilepsy is downregulated by Copperu2010zinc superoxide dismutase, but the role of Cuu2010Zn SOD in epilepsy remains uncertain. Based on field excitatory postu2010synaptic potentials, cortical and striatum brain slices of rats were examined in the cortical post-u2010striatum brain slices of rats. In addition, Cuu2010Zn SOD knockdown reduced SOD production and induced apoptosis in SHu2010SY5Y cells, which caused apoptosis. Cuu2010Zn SOD attenuated epilepsy and was shown to reduce the expression level of proteins of the NaV1. 2/HOu20101 signalling pathway, indicating that Cuu2010Zn SOD could be a target for epilepsy treatment.

Source link: https://onlinelibrary.wiley.com/doi/10.1684/epd.2022.1434


Influence of personality profile in patients with drug‐resistant epilepsy on quality of life following surgical treatment: A 1‐year follow‐up study

The goal of this research was to determine the influence of personality profil in patients with drug-resistant epilepsy following surgical treatment, as well as compare the results with a non-u2010surgical control group at the 1u2010-year follow-up. We found differences in scores of several items of QoL, which were higher in those patients who had undergone surgery at the 1100th anniversary of U2010's 1u2010yu2010up, comparing the control and surgical groups. Patients who underwent surgery predicted improved post-u2010surgical outcomes in the QoL scores, but high neurotic patients had worse QoL results, according to the QoL results. Patients' postoperative changes in QoL were correlated with their individual profile at the time. QoL metrics in the surgical group have significantly improved in the surgical group in comparison to the non-u2010surgical group, but there were no statistics or postoperative seizure rates at 1 year.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/pmh.1564


Innovative treatments for epilepsy: Venom peptides, cannabinoids, and neurostimulation

Abstract Abstract: Antiepileptic drugs have been used successfully to treat epilepsy and delivering seizure relief to patients. However, about 30% of epilepsy patients have drug resistance, indicating that they are not responding to drug therapy. Since it is now known that this network is involved in epilepsy's pathophysiology, other alternatives are cannabinoids and proteins that modulate the endocannabinoid system. In addition, neurostimulation is another tactic, as an alternative medical therapy for drug-u2010-resistant patients who are unqualified for palliative surgery.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jnr.25114

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions