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Epilepsy Treatment - DOAJ

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Last Updated: 01 September 2022

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Novel Phenobarbital-Loaded Nanostructured Lipid Carriers for Epilepsy Treatment: From QbD to In Vivo Evaluation

Pharmacological treatments of central nervous system diseases are always challenging due to the restrictions imposed by the bloodu2013brain barrier: although some drugs can safely cross it, several others, including some antiepileptic drugs, pose permeability problems in order to reach the point of action and exert their pharmacological effects. In the last few years, the introduction of last-generation therapeutic nanosystems capable of improving drug biosynthesis has gained traction. By a quality by design approach, nanostructured lipid carriers containing the antiepileptic drug phenobarbital were created and optimized in the present work. Using FTIR, drug localization and potential interactions between the drug and the formulation components were investigated. In vitro cytotoxicity, non-tumoral mouse fibroblasts L929, and in vivo anticonvulsant activity in an animal model of acute seizures were investigated as well.

Source link: https://doi.org/10.3389/fchem.2022.908386

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions