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Animals u201412 cats were reported to have idiopathic epilepsy that was poorly managed with phenobarbital or that had no adverse effects when treated with phenobarbital were rescued. Following a minimum of one week of therapy, serum levetiracetam levels were determined before and 2, 4, and 6 hours after drug administration, and maximum and minimum serum concentrations and elimination half-life were estimated. Median's highest serum levetiracetam concentration was 25. 5 u03bcg/mL, median minimum serum levetiracetam concentration was 8. 3 u03bcg/mL, and median elimination half-life was 2. 9 hours. Following levetiracetam therapy, 7 of ten cats were classified as having responded to levetiracetam therapy, according to a median seizure frequency prior to treatment. Conclusions and Clinical Efficacy u2014 Results showed that levetiracetam is well tolerated in cats and can be used as an adjunct to phenobarbital therapy in cats with idiopathic epilepsy.
Source link: https://doi.org/10.2460/javma.232.6.867
Epilepsy is a common medical disorder among all age groups. Both infants, febrile seizures, and juvenile myoclonic seizures are typical. Epilepsy can be new onset or present since childhood in both adults and seniors. Epilepsy treatment is available with a variety of antiseizure drugs. When choosing drug therapy, several risk factors, including patient-related risk, seizure incidence, and epilepsy type are among those that may be considered. When choosing an appropriate treatment option for epilepsy, elderly patients also have to be concerned. Advisory board meetings with a group of expert neurologists were held in eight cities around India to gain medical evidence on epilepsy management in various age groups. Except in females of childbearing age, valproate remains a commonly used drug in India. Levetiracetam is preferred due to its safety profile, but clobazam is a more popular first add-on therapy.
Source link: https://doi.org/10.18203/2320-6012.ijrms20222292
Epilepsy caused by PCDH19 is a developmental and epileptic disorder that is commonly associated with epilepsy and varying degrees of intellectual impairment. Seizures typically appear in clusters of focal or generalized seizures, often in the setting of fever. We discuss the case of a 7-month-old girl who had refractory status epilepticus that occurred after routine vaccination administration and a resulting cytokine storm. Anakinra was started and titrated based on serial cytokine levels, with doses ranging from 5 to 20 mg/d resulting in a decrease in cytokine levels and seizure reduction.
Source link: https://doi.org/10.1212/wnl.0000000000200855
BACKGROUND METROPEDIA BACKGROUND Musicogenic epilepsy is a rare reflex epilepsy in which seizures are triggered by musical stimuli. Although resection has been described as a medical cure for ME, other surgical techniques, such as laser ablation, have been shown to dramatically disrupt seizure networks in ME while still posing comparatively low risks of morbidity. The authors illustrated the use of laser ablation to treat ME arising from the primary mesial temporal structures. LESSONS Laser ablation can be a safe treatment option for well-localized forms of ME, particularly when seizures arise from the dominant mesial temporal lobe.
Source link: https://doi.org/10.3171/case2295
Objective: To determine the likely influence factors on 25-OH-VitD levels, the key indicator of vitamin D status, in healthy children and epilepsy patients prior to the introduction and use of anti-seizure medications therapy and to determine the potential influence factors on 25-OH-VitD levels. Methods For comparison, we recently enrolled and collected data from 6,338 healthy children and 648 children attending primary care pediatricians with epilepsy symptoms in Children's Hospital of Nanjing Medical University from January 2019 to June 2021. The percentage of VitD insufficiency and deficiency status in pediatric patients was 51. 9 percent lower than those in 6,338 healthy children. Significance in this retrospective analysis The childhood epilepsy during ASMs treatment dropped the serum 25-OH-VitD levels, indicating a clear correlation between epileptic disease and the risk of VitD deficiency.
Source link: https://doi.org/10.3389/fnut.2022.968868
U2713 Twenty-five cases of intractable epilepsy were treated with combined deep general and local extravascular brain hypothermia, as well as single doses of pentothal or diazepam. The final local temperature of 21 patients was below 24 u00b0C, with the rectal temperatures rising from 27°00b0 to 30°u00b0C. Postoperatively, three patients' improvements in behavior and emotional stability were noted; this change was independent of the frequency of seizures' decreases.
Source link: https://doi.org/10.3171/jns.1970.33.3.0253
OBJECTIVE The aim of this research was to determine seizure activity, clinical results, and the withdrawal of antiepileptic drugs after conservative or surgical treatment of patients with new-onset cavernoma-related epilepsy. The IS group's 5-year average was 73%, 22% for the IC group, and 68% for the DS group. Long-term operative morbidity in the conservatively treated group was 3%, while long-term morbidity in the conservatively treated group was also 3%. CONCLUSIONS Patients with CCM and new-onset CRE who received IS treatment had higher success in seizure control and AED discontinuation than those with conservatively treated patients. Operative morbidity in the conservative group was similar to the morbidity caused by symptomatic CCM hemorrhage. Half of the patients who started with conservative medical care underwent follow-up surgical intervention; however, a longer course of epilepsy prior to surgery did not exacerbate postoperative seizure syndromes.
Source link: https://doi.org/10.3171/2016.4.jns1661
OBJECTIVE TEMPLE epilepsy is the most common form of pharmacoresistant focal epilepsy, for which anterior mesial temporal lobe resection is a treatment option. The authors look at the effects of FCD IIIa on seizure outcomes in patients with TLE who underwent AMTLR in this report. METHODS The authors conducted a retrospective review of all patients with TLE who underwent AMTLR at their hospital between June 2011 and April 2014. Patients were assessed whether they had HS together with FCD I or HS alone, using histopathological analysis. RESULTS The authors'u2019 center performed AMTLR at the authors' institution, with a total of 51 patients with TLE underwent AMTLR. Compared to 71% of the patients with no pathological findings in the temporal pole, all patients with FCD IIIa had a good seizure result. Patients with HS alone had a significantly reduced seizure incidence after AMTLR than patients with HS alone.
Source link: https://doi.org/10.3171/2017.2.jns161295
OBJECTIVE This paper was published in Vietnam and sought to describe an international collaboration scheme to enable the surgical care of children with epilepsy. The Vietnamese surgeon continued to perform ten more callosotomy procedures in the ensuing 6 months with excellent success after two operations together. Pediatric epilepsy care in Vietnam requires more than neurosurgery, according to the team traveling to Vietnam, which included a pediatric neurologist and an electroencephalography technologist. The Vietnamese team regularly submits case summaries for discussion to the COA epilepsy conference. Three patients in Vietnam underwent resection by ECoG without the U. S. team's presence, although there was communication between Vietnamese and American EEG technologists via internet-based telecollaboration tools. At two international functional and epilepsy surgical scientific meetings, the Vietnamese team has presented the findings of their epilepsy research. CONCLUSIONS Ongoing international cooperation has enhanced epilepsy surgical treatment in Vietnam, according to CONCLUSIONS.
Source link: https://doi.org/10.3171/2018.7.focus18254
OBJECTIVES Since its inception in the 1970s and 1980s, epilepsy's deep brain stimulation field has exploded rapidly. The aim of this review is to identify and evaluate all studies published on the topic of open-loop DBS for epilepsy over the past decade. METHODS THE METHODS The following articles describing the clinical findings of open-loop DBS for epilepsy treatment have appeared since January 1, 2008. Level I evidence supports the safety and efficacy of stimulating the anterior nucleus of the thalamus and the hippocampus for the treatment of medically refractory epilepsy. Ongoing research into the safety, adverse effects, and mechanisms of open-loop DBS is continuing to expand the body of evidence supporting the use of these treatment techniques in patients with refractory epilepsy.
Source link: https://doi.org/10.3171/2018.5.focus18161
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