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Epidemic - DOAJ

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Last Updated: 25 June 2022

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Heterogeneous epidemic modelling within an enclosed space and corresponding Bayesian estimation

This paper introduces a heterogeneous epidemic model that divides the incubation period into infectious and non-infectious, while the Bayesian framework is used to model the u2018Diamond Princessu2019 enclosed space event. As the COVID-19 pandemic continues, our mathematical analysis can inform government and policy makers on how the COVID-19 disease has spread and what prevention steps still need to be taken.

Source link: https://doi.org/10.1016/j.idm.2022.02.001


Numerical simulation of a Caputo fractional epidemic model for the novel coronavirus with the impact of environmental transmission

In China, the coronavirus infectious disease is a novel respiratory disease. Several attempts have been taken lately to better understand COVID-19's complex dynamics. The mathematical modeling approach is one of the most effective methods to investigate the disease spreading pattern. In the sense of Caputo's Caputo operator, we propose a fractional order epidemic model for COVID-19 in this article. To analyze disease dynamics, the model is based on the most reliable contacts among the population and environmental factors. The fractional models are still far superior in detecting the disease outbreak and providing greater insight into infectious disease epidemiology. We first investigate the classical integer model that has been discussed in recent literature and then generalize it by introducing the Caputo fractional derivative. Lastly, the effect of some of the model's most influential variables on the disease's dynamics is shown graphically.

Source link: https://doi.org/10.1016/j.aej.2021.10.008


Prevention and Control of Porcine Epidemic Diarrhea: The Development of Recombination-Resistant Live Attenuated Vaccines

2 PEDV, the highly virulent genogroup 2 PEDV, appeared in 2010 and has caused significant economic losses to the pork industry around the world. The most effective way to boost lactogenic immunity in the sows/gilts and provide a non-violent defense against PED is to vaccinate pregnant sows/gilts with live attenuated vaccines. In this report, we detail the status and the major obstacles in PEDV LAV development. We also discuss the role of the transcriptional regulatory sequences in PEDV transcription, contributing to recombination and potential solutions to prevent LAVs from returning to LAVs.

Source link: https://doi.org/10.3390/v14061317


Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus In Vitro and In Vivo

The genus Alphacoronavirus of the family Coronaviridae causes severe diarrhea and high mortality in neonatal suckling piglets, according to the genus Alphacoronavirus. We first discovered that CEP, TET, and FAN had anti-PEDV activity with IC 50 values of 2. 53, 3. 50, and 6. 69 bcM, respectively. The compounds might have blocked all viral cycles, but early application of the vaccines before or during virus replication was preferable over late stage virus replication. In vivo, CEP in a safe dose of 11. 1 mg/kg of body weight could reduce viral load and pathological change of piglet intestinal tracts caused by the PEDV field strain challenge, indicating that CEP successfully blocked PEDV infection. All of these results showed that bis-benzylisoquinoline alkaloids' compounds inhibited PEDV proliferation effectively, and that PED prevention and treatment could be developed.

Source link: https://doi.org/10.3390/v14061231


Comparison of Endemic and Epidemic Vesicular Stomatitis Virus Lineages in Culicoides sonorensis Midges

The vesicular stomatitis virus is primarily infectious in livestock and is spread by direct contact and vectored by Culicoides midges. A monophyletic epidemic lineage 1. 1 spread northward into the United States in 2012. The role of specific viral lineages in Mexico's ability to bypass endemic regions and successfully cause outbreaks in the United States is uncertain, as well as the genetic basis for such outbreaks. Both epidemic VSV 1. 1 and endemic VSV 1. 2 showed significant differences in only seven amino acids. VSV 1. 1 was more virulent than VSV 1. 2, according to previous swine research. Our results revealed that midges orally infected with the epidemic VSV 1. 1 lineage had significantly higher infection transmission rates than those infected with the endemic VSV 1. 2 lineage.

Source link: https://doi.org/10.3390/v14061221


Poly(A)-Binding Protein Cytoplasmic 1 Inhibits Porcine Epidemic Diarrhea Virus Replication by Interacting with Nucleocapsid Protein

The etiological agent of porcine epidemic diarrhea with stenchemia, watery diarrhea, dehydration, and high mortality is Porcine epidemic diarrhea virus. Across the world, outbreaks of highly pathogenic variant strains of PEDV have resulted in significant economic losses to the swine industry. The analysis of host-u2013virus interactions can help to better identify viral pathogenicity. These findings, when taken together, show the antiviral activity of PABPC1 against PEDV replication by interacting with N protein, which improves knowledge of PEDV and host interactions.

Source link: https://doi.org/10.3390/v14061196

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions