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Engineering - Europe PMC

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Last Updated: 05 July 2022

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A commentary on the practice of integrated medical curriculum in the interdisciplinary field of medical engineering.

In 2018, Shanghai University School of Medicine, a newly established medical school, was a newly established medical college.

Source link: https://europepmc.org/article/MED/35272541


A Versatile Agrobacterium-Based Transformation System for Genetic Engineering of Diverse Citrus Cultivars

Citrus genetic engineering Here, we introduce an Agrobacterium tumefaciens-based transformation scheme. The procedure involves turning seedling-derived epicotyl segments with an A. tumefaciens strain, as well as selecting and regenerating transformed tissue. Transgene integrations among the transgenic lines varied from one to four. In addition, we show that including A. tumefaciens helper genes, spermidine, and lipoic acid in the resuspension buffer before transformation enhanced the transformation yield of specific recalcitrant cultivars, presumably by increasing T-DNA alignment and relieving oxidative stress on the explant tissues.

Source link: https://europepmc.org/article/PPR/PPR513321


Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance.

Compared to traditional NIR-II building block benzobisthiadiazole and 6,7-g]quinoxaline, we find an electron acceptor, 6,7-di-[1,2,5]quinoxaline with the highest degree of stability in alkaline conditions. Similar to FT-TQT alone, a FT-TQT complexed with FBS is also prepared and shows a 16-fold increase in fluorescence intensity relative to FT-TQT alone. By NIR-II fluorescent imaging, dynamic monitoring of tumor vascular disruption following drug therapy is possible. Acceptor engineering's paper presents a promising start to produce the next generation of NIR-II fluorophores, which have emerged in new biomedical applications.

Source link: https://europepmc.org/article/MED/35780137


Biotransformation pathway and side reaction engineering for the whole-cell production of glycolic acid from formaldehyde

conversion rates increased to 92% with conversion rates up to 20. 3 U/g dry cells. This research will help ensure the sustainability of the green energy industry by synthesizing useful C2 chemical from a single carbon compound, formaldehyde.

Source link: https://europepmc.org/article/PPR/PPR512973


Engineering Grain Boundaries in Two-dimensional Electronic Materials.

Engineering the boundary structures in two-dimensional materials provides unprecedented opportunity to control the physical properties of the materials with extensive tunability and produce new devices with advanced functionality. However, structural engineering technology is still in its infancy, and creating artificial boundary structures with high reproducibility is difficult.

Source link: https://europepmc.org/article/MED/35777352


Strategy for Engineering High Photolysis Efficiency of Photocleavable Protecting Groups through Cation Stabilization.

In several research fields, such as photopharmacology, where remote spatiotemporal control of a molecule is required, photolabile guard groups enable precise activation of molecular function. In recent years, PPGs' design and usage have particularly concentrated on the manufacture of molecules with high molar absorptivity at long irradiation wavelengths. Our approach resulted in systems containing up to a 35-fold increase in QY and a quick fluorescent readout during their uncaging, as well as requiring the same number of synthetic steps for their preparation as the traditional coumarin PPGs. We show that the same QY engineering approach applies to various photolysis payloads and even different classes of PPGs. In addition, DFT-calculated energy barriers in the first singlet excited state of a single singlet excited state provide valuable insight into the key factors that determine photolysis's effectiveness.

Source link: https://europepmc.org/article/MED/35775744

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions