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Gra-negative bacteria are causative agents of endogenous endophthalmitis. Methods: All peer-reviewed papers relating to Gram-negative EBE were published between January 2002 and August 2022, including Gram-negative EBE. Vitectomy and evisceration/exenteration were the most common surgical procedures. Visual acuity at discharge was often overlooked, although no light perception was present. Conclusions: Poor results are usually associated with gram-negative EBEs. Our systematic investigation is mainly based on case reports and case series of high heterogeneity. Our results show how important it is to investigate ocular involvement in Gram-negative infections.
Source link: https://doi.org/10.3390/microorganisms11010080
C. albicans and the majority of the infections caused by non-albicans species, mainly by C. parapsilosis and C. dubliniensis. C. tropicalis and Clavispora lusitaniae were two isolates of one isolate each, and Clavispora lusitaniae was found. Interestingly, all C. dubliniensis were isolated from endophthalmitis and the majority of C. parapsilosis from keratitis. According to a multilocus sequence typing study of C. albicans, there was a prevalence of CC-1 isolates that have DST69 as the putative founder, with 64% of them being related to this clonal complex. One C. albicans CC-1 isolate was multi-azole resistant. We found that nearly half of the ocular infections caused by yeasts are related to C. albicans, as well as other ocular niches in different ocular niches. Candida albicans isolates clustered within the dominant CC-1 group were particularly prevalent in endophthalmitis, highlighting a potential pattern of ocular disease enrichment within this group.
Source link: https://doi.org/10.1093/mmy/myac099
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