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Patients with EE over three decades at Peking Union Medical College Hospital were retrospectively reviewed and analyzed. Output: The result was a total of 97 eyes from 81 patients. Diabetes mellitus was the most common predisposing medical condition. DM was found in more than 80% of patients with liver abscess, which was significantly more prevalent than other etiologies. The EE due to liver abscess had a lower initial visual acuity than that of liver abscess. Surgical procedures for EE due to liver abscess were significantly shorter than those for other conditions, but the prognosis was poorer. Patients who underwent pars plana vitrectomy + silicone oil tamponade underwent fewer general procedures, and no eyes required additional intravitreal injections. The earliest signs and prognosis of EE after liver abscess were the worst. As an initial therapy, PPV + silicone oil tamponade can be used to reduce additional therapy.
Source link: https://europepmc.org/article/PPR/PPR575965
Purpose: To discuss our experiences and surgical results with the three-dimensional visualization device in endophthalmitis vitrectomy. Methods: 11 cases of endophthalmitis had undergone NGENUITY's assisted23-gauge vitrectomy at Xuzhou First People's Hospital between 1 March 2020 and 2022, according to a same surgeon at Xuzhou First People's Hospital. : Results: : In all cases with lower intensity of intraoperative light on the 3D visualization device, no errors were identified on the visualization system, and no one of them were dismissed or converted to the conventional microscope.
Source link: https://europepmc.org/article/PPR/PPR574755
Objects Objectives: To assess the potential role of combined pars plana vitrectomy and intravitreal antibiotics in the acute treatment of exogenous endophthalmitis, versus the medical therapy approach, which is characterized as vitreous tap and intravitreal antibiotics. Ovid Embase; Ovid MEDLINE; Ovid Embase; the International Standard Randomised Trial Number registry; ClinicalTrials. gov; and the World Health Organization International Clinical Trials Registry Platform; We searched the Cochrane Central Register of Controlled Trials; Ovid Embase; and the World Health Organisation International Clinical Trials Registry Platform. For the immediate treatment of exogenous endophthalmitis, we used randomised controlled trials that compared pars plana vitrectomy and intravitreal injection of antibiotics versus intravitreal injection of antibiotics alone. Three and six months, visual acuity improvement and change in visual acuity; additional surgical procedures, including vitrectomy and cataract surgery, were considered during follow-up; quality of life and adverse effects. Within six weeks of cataract surgery or secondary intraocular lens implantation, the participating RCT enrolled a total of 420 participants with clinical evidence of endophthalmitis, within six weeks of cataract surgery or secondary intraocular lens implantation. 41% of all participants reached 20/40 or better visual acuity, while 69% had 20/100 or better acuity at three months, and 69% had 20/100 or better acuity. CONCLUSIONS OF AUTHORS' CONCLUSIONS: We found a single RCT for the role of early vitrectomy in exogenous endophthalmitis, which means that there may be no difference between groups for visual acuity at three or nine months' follow-up. We're of the belief that more randomised research comparing the role of primary vitrectomy in exogenous endophthalmitis is needed.
Source link: https://europepmc.org/article/MED/36398614
Purpose The purpose of this survey is to determine if certain aspects of endophthalmitis prophylaxis measures are superior to others. Except for ciprofloxacin monotherapy, which had less effective outcomes, the antibiotic regiments differed from vancomycin/u2265 3rd generation cephalosporin. Conclusions: The risks of antibiotic therapy > 24 h and administration techniques other than oral antibiotic formulations should be considered seriously by future antibiotic strategies. In addition, physicians should be suspicious of using ciprofloxacin monotherapy for endophthalmitis prophylaxis when treating open globe injuries.
Source link: https://europepmc.org/article/MED/36396863
This review sought to establish, refine, and evaluate an intelligent decision support system for acute postoperative endophthalmitis. Prioritizing was given to ophthalmologists with a list of clinical signs of acute postoperative endophthalmitis. The acute postoperative endophthalmitis diagnosis kit was designed for use by physicians and patients. 3693 acute postoperative endophthalmitis patients, 3693 acute postoperative endophthalmitis cases, and 12 non-acute postoperative endophthalmitis records were found based on the research of 60 acute postoperative endophthalmitis patients, 3693 acute postoperative endophthalmitis infections, 3693 acute postoperative endophthalmitis infections, and 12 non-acute postoperative endophthalmitis cases. The algorithm's learning process was conducted on 70% of the data, and 30% of the data was used for evaluation. The creation of a decision support system with accuracy, precision, and sensitivity above 90% was achieved thanks to all-round participation and drawing on clinical experts' experiences and their knowledge of patient needs, as well as the availability of extensive acute postoperative endophthalmitis clinical data.
Source link: https://europepmc.org/article/PPR/PPR572614
Endogenous endophthalmitis is an ophthalmic emergency that can result in severe sight-threatening complications. The new study compared EE in patients with and without COVID-19 infection. Methods In this prospective case-control review, there were 58 cases of EE admitted to Khalili Hospital between April 2020 and September 2021. Patients were divided into two groups, the case group and the control group. The sepsis workup, causative microorganism, types of therapy, and follow-up period were all reported, with age, sex, presenting and final visual acuity, systemic disorders, and risk factors for EE, anterior segment and fundus studies, hospitalization due to COVID-19, intensive care unit admission, systemic steroid therapy, and follow-up period. Positive intraocular culture findings were found in seven patients. Two out of seven patients had a history of COVID-19 infection. Conclusions The COVID-19 infection does not appear to have an effect on the severity, visual appearances, increased rate, or vitrectomy rate of EE.
Source link: https://europepmc.org/article/MED/36425881
Postcataract endophthalmitis, a life-threatening condition after cataract surgery, is one of the most common disorders causing irreversible eye blindness. The released gallium ions can cause bacterial iron metabolism to be disrupted. The slit-lamp dispersion and retro-illumination micrograph, ophthalmic clinical grading, and etiological histopathology report showed that Ga-mSiO 2 -BFN could eliminate the MDR infection and minimize secondary inflammation of MDR-PA infection in the PCE rabbit model, as well as a secondary inflammation of MDR-PA infection. Comprehensive assays of iron antagonism evolution, colony autofluorescence, polymerase chain reaction, and electron microscopy revealed a repressing siderophore peptide pyoverdine, pyoverdine synthetase D, and interference with bacterial DNA synthesis. All composites of our nanoplatform were FDA-approved, making the Ga-mSiO 2 -BFN as a potentially effective therapeutic treatment of MDR-PA in PCE, as shown by encouraging prognosis and prospects for clinical translations.
Source link: https://europepmc.org/article/MED/36373472
Methods Preoperative topical antibiotic prophylaxis versus no-prophylaxis costs and effects were estimated over a life-time horizon for a simulated cohort of 500,000 adult patients requiring cataract surgery in theoretical surgical centers in the United States, compared to no-prophylaxis. If the price of the preoperative topical antibiotic prophylaxis was less than $0. 75, we'll assume a cost-effectiveness criterion of 50,000 dollars per QALY gained. Assuming a profit-effectiveness criterion of u2264$ 50,000 per QALY gained, the threshold estimates showed that prophylaxis would be cost-effective if the risk of endophthalmitis after cataract surgery was higher than 5. 5 percent or if the preoperative topical antibiotic prophylaxis inflammatory topical antibiotic prophylaxis was less than $0. 75, cri compared to phylaxis was less than critic pharmacien milia demonstrates was less than a Conclusions General Use of preoperative topical antibiotic prophylaxis for the prevention of endophthalmitis after cataract surgery is not cost-effective relative to no-prophylaxis. However, preoperative topical antibiotic prophylaxis would be cost-effective at a higher risk of endophthalmitis and/or a substantially lower price for prophylaxis than other antibiotic prophylaxis.
Source link: https://europepmc.org/article/MED/36375588
Purpose of this Essay is a retrospective case report in which we discuss our findings in two cases of endophthalmitis related to a gunshot injury, in which we reported intraocular intrusion of multiple eyelashes as a possible source of infection. Patients and techniques Two male patients, 22 and 29, respectively, were diagnosed with endophthalmitis following primary repair of rupture globe secondary to gunshot injury in primary. To prevent the presence of occult lashes, we recommend careful examination of the posterior segment and the pars plana region during vitrectomy.
Source link: https://europepmc.org/article/MED/36388242
Purpose The aim of the study was to determine the incidence of endophthalmitis and blebitis after deep sclerectomy and trabeculectomy using Mitomycin C 0. 4 mg/ml. Methods of diagnosis Patients who underwent surgery from 1/2008 to 2020 were reviewed electronically by physicians who underwent surgery from 2008 to 2020. Cumulative incidence for bleb-associated infection, which included both endophthalmitis and blebitis, was estimated with cumulative incidence function and Kaplan-Meier analysis. Univariate competing risk regression analysis and Log-rank analysis were used to determine BAI risk factors for BAI. The most recent surgery on the eye until the end of the investigation was 5. 5 years, and the ophthalmology department's last visit was 1. 9 years. During the five years of CIF-analysis, the incidence of BAI was 0. 6 percent at five years. The cumulative risk of gastrointestinal disorders following surgery and last visit to Kaplan-Meier's study was 0. 2 percent at five years, with no use of an antifibrotic increased risk.
Source link: https://europepmc.org/article/MED/36352754
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