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Endophthalmitis - Crossref

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Last Updated: 26 January 2023

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An Outbreak of Fungal Endophthalmitis After Cataract Surgery in South Korea

Fungal endophthalmitis caused by contaminated medical products is extremely rare, and it comes as a result of an intractable clinical course with a poor visual prognosis. Objectivis Objectives In South Korea, an article aims to detail the epidemiologic and clinical characteristics and treatment results of a nationwide fungal endophthalmitis epidemic following cataract surgery due to contaminated viscoelastic agents. Using multiple institutions in South Korea, from September 1, 2020, to October 31, 2021, this was a retrospective case series review of clinical evidence from various institutions. This was a retrospective case series analysis of medical findings from multiple institutions. Patients were diagnosed with fungal endophthalmitis as a result of the use of the viscoelastic material sodium hyaluronate. Key Outcomes and Measures The medical characteristics and causative species were identified, and treatment outcomes were determined for patients who underwent six months of follow-up. Fungal endophthalmitis was reported in all 281 eyes of 265 patients, based on medical investigations and supportive culture findings, and clinical trials. The average time period between cataract surgery and diagnosis was 24. 7 days. In 89 eyes, Fusarium species had been identified in 89 eyes, among them. The mean best-corrected visual acuity increased from 0. 78 logMAR to 0. 36 logMAR at 6 months among the 228 eyes included in the treatment outcome study. Conclusions and Relevance This was a retrospectively reviewed case series of a fungal endophthalmitis outbreak resulting from contaminated viscoelastic waste. The findings of this case series report point to the possibility of prompt, targeted surgical intervention that may reduce hospitalization and improve prognosis of fungal endophthalmitis caused by contaminated medical products.

Source link: https://doi.org/10.1001/jamaophthalmol.2022.5927


Intravitreal injections as a leading cause of acute postoperative endophthalmitis—a regional survey in England

Background Information Objectives: Objective Objectives: To investigate the characteristics, treatment patterns, and results of acute postoperative endophthalmitis. Patients with acute postoperative endophthalmitis between January 2017 and December 2019 were identified from hospital records in this multicentre retrospective cohort study. Endophthalmitis risk in intravitreal injections was 0. 02 percent for cataract surgery, 0. 01 percent for cataract surgery, and 0. 07 percent for vitreoretinal surgery. The majority of patients had improved VA at 6 months compared to presentation, but fewer had similar or better VA compared to before the precipitating surgery. The microbiological yield was not related to improved final visual results. Patients who underwent surgical vitrectomy had poorer VA at display, but they later achieved similar visual results to those who received medical intervention alone. Conclusion Intravitreal injections were the most common cause of endophthalmitis in our region, mainly because of their higher rate compared to other intraocular procedures.

Source link: https://doi.org/10.1038/s41433-021-01886-3


Post Pars Plana Vitrectomy Silicone Oil Related Endophthalmitis Caused by Citrobacter Koseri: A Case Report and Literature Review

Purpose: To display a rare case of a Citrobateri koseri endophthalmitis after pars plana vitrectomy silicone oil-filled eye. Case Report: A 64-year-old male patient was admitted to our clinic for eye pain and reduced vision in the right eye. After one week, the patient complained of ocular pain and reduced vision. C. koseri's microscopic examination of the aqueous fluid stained with Gram stain revealed the presence of numerous polymorphonuclear cells and small gram-negative bacteria. The treatment was changed to fortified ceftazidime 5%, fortified tobramycin 0. 3, atropine 1%, atropine 1%, atropine 1%, and prednisone-eye drops were administered every 2 hours along with systemic antibiotic and steroid therapy with no improvement. Citrobacter spp. is the product of culture-positive endophthalmitis.

Source link: https://doi.org/10.23880/oajo-16000213


Safety Profile of Intravitreal Injections in the Injection Cabinet: No Cases of Endophthalmitis Seen After 7,238 Injections

Object : The present research examines endophthalmitis in intra vitreal injections that could be conveniently located in a closet in an office environment, as well as the cabin's performance in terms of heating, ventilation, and air conditioning. The injections were given over the 18 months in the cabin and the patient's demographics were reviewed retrospectively, and the cabin was exposed to HVAC tests.

Source link: https://doi.org/10.21203/rs.3.rs-2446329/v1


Visual Outcomes and Prognostic Factors of Traumatic Endophthalmitis Treated by Pars Plana Vitrectomy: 11 Years Retrospective Analysis

Aim: To assess the visual results of traumatic endophthalmitis (visual) and identifie the risk factors associated with inadequate visual acuity and retinal detachment growth over an 11-year period. Methods: The medical records of 34 patients with traumatic endophthalmitis who underwent PPV for a period of 11 years were reviewed. Conclusions: According to the final BCVA, the incidence was either poor (0) or excellent 0. 1 percent in open globe injuries. All patients were treated with systemic and intravitreal antibiotherapy. In all cases, we performed pars plana vitrectomy. RD development was correlated with the presence of IOFB and wound size u2265 3 mm. U2265 0. 1. Patients in recovery, 47. 0 percent of patients achieved final BCVA after treatment, and 47. 05% of patients were deemed by an end BCVA. Conclusion: The wound size was u2265 3 mm, IOFB, and RD were risk factors for poor visual results in traumatic endophthalmitis.

Source link: https://doi.org/10.3390/jcm12020502


Molecular characterization of fungal endophthalmitis and keratitis caused by yeasts

Abstract Candida species are the most common causes of sight-threatening fungal ocular infections in temperate regions of the world. With 58% of the infections caused by C. albicans and the remainder caused by emerging non-albicans species, mainly by C. parapsilosis and C. dubliniensis, 58% of the cases were caused by C. albicans and the remainder by emerging non-albicans species. C. tropicalis and Clavispora lusitaniae are both species of C. tropicalis and Clavispora lusitaniae. Interestingly, all C. dubliniensis were isolated from endophthalmitis and the majority of C. keratitis sufferers were isolated from endophthalmitis. A clonal complex analysis of C. albicans revealed a syring of CC-1 isolates that had DST69 as the putative ancestor, with 64% of them attributed to this clonal complex. One C. albicans CC-1 isolate was multi-azole sensitive, and it was multi-azole sensitive. In conclusion, we found that nearly half of the ocular infections caused by yeasts in C. albicans, as well as evidence for the emergence of non-albicans species that are differentially enriched in specific ocular niches.

Source link: https://doi.org/10.1093/mmy/myac099


Bee sting presumed endophthalmitis: a devastating ocular outcome

Abstract Background: To be precise, there is no evidence of a rare case of bee sting ophthalmitis resulting in a devastating ocular result. Case study A 43-year-old patient was presenting a bee sting ocular injury in his left eye for the fourth time 24 h after being treated for a bee sting ocular injury in his left eye for the first time. The condition deteriorated to the point of panophthalmitis stage and cellulitis like image, with visual acuity of no light perception. Visual stimulated reaction illustrated a stumbling response with a stifled reaction. Infection was contained by evisceration of the globe at the end as recovery efforts against the spread of disease. Conclusions Beesting ocular injury is an extremely rare form of ocular trauma.

Source link: https://doi.org/10.1186/s40942-021-00320-w


Pars plana vitrectomy and therapeutic keratoplasty in endophthalmitis and infectious keratitis

Objectives: To describe the anatomical and functional results of patients with infectious keratitis and secondary endophthalmitis who underwent penetrating keratoplasty after pars plana vitrectomy with temporary keratoprosthesis after pars plana vitrectomy. Conclusions A total of 32 eyes of 32 patients were examined. Hand motion VA is a condition that has caused 33% patients to live or improve their best-corrected VA, while 37. 5% of patients had hand motion VA. Conclusions and research show that PPV combined with PKP can be a safe option for treating patients with endophthalmitis secondary to IK, which can lead to further visual enhancement following an optical PK.

Source link: https://doi.org/10.1177/11206721221118151


Temporal retinal transcriptome and systems biology analysis identifies key pathways and hub genes in Staphylococcus aureus endophthalmitis

BACterial endophthalmitis is a chronic inflammatory disease associated with permanent vision loss. We discovered continual evolution in the expression of 1,234 genes in mice using a mouse model of Staphylococcus aureus endophthalmitis and retinal transcriptome analysis. The down-regulation of inflammatory regulatory genes was demonstrated by the down-regulation of inflammatory gene expression in SA endophthalmitis, counterregulation of TLR2 ligand pretreated retina or the use of retinas from TLR2 knockout mice. For the first time, our study provides a comprehensive review of the transcriptomic response and identifies key pathways that control retinal innate responses in staphylococcal endophthalmitis.

Source link: https://doi.org/10.1038/srep21502

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions