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ENERGY - U.S. Department of Veterans Affairs

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Last Updated: 03 August 2022

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Orexin, serotonin, and energy balance.

Evidence reveals that lateral hypothalamic orexin neurons function as regulators of feeding and SPA. These neurons affect a variety of organs, as well as several brain regions, including the dorsal raphe nucleus, which contains serotoninergic neurons that are vital to energy homeostasis. SPA is an activity that is not influenced by rewards such as food or a running wheel in animals. This article discusses hypothalamic orexin's role in energy-homeostasis, the interaction with DRN serotonin neurons, and the role of this orexin-serotonin axis in governing food intake, SPA, and EE. animal models of obesity, impaired serotonin function, and future directions in the orexin-serotonin cross-talk; oral, transportation, and uptake-inhibitors all play a role in orexin-serotonin cross-talk; orphanage, transporters, and uptake-inhibitors; and future directions in the orexin-serotonin-based obesity prevention and management of obesity; animal models of obesity with reduced seroton.

Source link: https://doi.org/10.1002/wsbm.1536


Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia.

In adult brains, where mitochondria remain relatively static, boosting local ATP production in injured axons is thus crucial to meet increased energy demand during nerve repair and regeneration. Kinase 5 in the brain is a brain mitochondrial kinase with decreased expression in mature neurons, according to a P21-activated kinase. Through the phosphorylation switch that switches off the axonal mitochondrial anchor syntaphilin, PAK5 signaling remobilizes and replaces damaged mitochondria. Our analysis shows an axonal mitochondrial signaling axis that responds to injury and ischemia by remobilizing injured mitochondria for replacement, thereby retaining local energy supply to promote central nervous system stability and regeneration.

Source link: https://doi.org/10.1016/j.cub.2021.04.079

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions