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Surprisingly little is known about how the body controls heat production in response to small changes in environmental temperature. For example, only recently has it been discovered that brown adipose tissue is still present in adult humans. If not compensated by changes in diet, small changes in EE may have long-term effects on body weight and may be contributing to body fat regulation and therefore may be contributing to the current obesity epidemic: even small changes in EE, which can not be compensated by changes in diet, may have long-term effects on body weight. The thermoneutral zone is the environmental temperature range over which EE is at a minimum and does not change with environmental temperature. The EE vs. environmental temperature graph at lower than average temperatures is reported to be a straight line, with the extrapolated X-axis intercept representing the defended body temperature at environmental temperatures below the lower critical temperature. With the global obesity epidemic coinciding with improved indoor temperature control, a better knowledge of the relationship between EE and thermoregulation is helpful. The expected differences can be seen in two lean and obese male cohorts in the second, as well as obese male cohorts, to ensure that no such disparities can be established. In particular, we will map the resting EE response to environmental temperatures in the NIH Metabolic Clinical Research Unit during inpatient stays at 16-31 degrees Celsius. Each day, resting EE will be measured in a room respiration calorimeter with a different environmental temperature. In the individual patient room, the remainder of each study day will be spent at 23-25 degrees Celsius.
Source link: https://clinicaltrials.gov/ct2/show/NCT01568671
In general, diet changes or new weight loss products will only result in about 5 to 10% weight loss. This research is designed to determine if changing energy use by changing temperature exposure results in changes in food intake. Participants will spend 24 hours in a room that monitors energy consumption, but the room's temperature is turned down, once with a set diet and then with a buffet of food choices. Volunteers will spend one day fasting and a day self-selecting their food from the vending machine. This information may help explain why some weight loss programs that raise energy expenditure do not work as well as expected, and may lead to new weight loss strategies and therapies.
Source link: https://clinicaltrials.gov/ct2/show/NCT02939404
Any bodily movement that necessitates energy expenditure is defined as physical fitness. A PA classification system can determine the amount of time spent in various body postures and fitness in order to determine the effects of PA on health and general well-being. They are a cost-effective way to collect objective PA data in daily life, in unobtrusive manner, at a very low price. Accelerometry has been used to measure PA and to predict EE using linear and non-linear equations. However, the relationship between EE and acceleration varies from one activity to another. For example, cycling can produce the same acceleration amplitude as running, but EE can differ substantially. Improving the estimation of EE could be achieved by first classifying the task type. When combined with accelerometry, heart rate, respiratory rate, and temperature have all been used to enhance the EE estimation in PA. The EE's estimation is therefore uncertain because the breathing rate and temperature could have contributed to the uncertainty. Firstly, to investigate the contribution of various variables to the estimation of EE and PA determinations, develop and validate a model to estimate EE and classify PA in simulated free-living situations based on the relevant variables.
Source link: https://clinicaltrials.gov/ct2/show/NCT05523830
According to the NOVA classification system, this is a randomized crossover study of adult volunteers to determine differences in mean ad libitum energy intake when exposed to four different diets that differed in non-beverage energy density, hyperpalatable foods, as well as the degree, presence, and purpose of processing.
Source link: https://clinicaltrials.gov/ct2/show/NCT05290064
Unlike white adipose tissue, brown adipose tissue has a high capacity for thermogenesis. Brown's adipose tissue may also influence the formation of neonatal energy balance. It is hypothesized that the growth of Brown adipose tissue in utero is also influenced by maternal factors such as prepregnancy body mass index and gestational weight gain, according to white adipose tissue. Brown adipose tissue and 2nd to determine changes in neonatal Brown adipose tissue and energy expenditure in response to a mild cold exposure, according to this research.
Source link: https://clinicaltrials.gov/ct2/show/NCT05517967
Participating participants are expected to demonstrate a desire for more energy, less fatigue, and/or improved focus during screening; they will avoid taking cannabinoids during the trial period; and show an interest in purchasing a plant-derived cannabinoid product to help with their energy and/or attention. Many people taking medications that warn against grapefruit intake will be refused admission. During baseline, during the active period of study product use, and in a final survey, participation in health monitoring will be collected. This real-world evidence survey will be purely electronic; there are no in-person visits or assessments for this real-world evidence study.
Source link: https://clinicaltrials.gov/ct2/show/NCT05502328
With all modern regimens, weight gain following antiretroviral therapy initiation occurs. According to recent real-world reports, integrationase strand transfer inhibitor -based ART may result in excess weight gain relative to other regimens. Weight gain seems to persist regardless of baseline weight, and is most noticeable among women and minorities, who are often at the highest risk of obesity-related comorbidities. This research is intended to explore the shifts in energy balance as a result of changes in ART. Participants with HIV who have a greater weight gain on INSTI will be transitioned to doravirine for 12 weeks and then back to their old INSTI regimen, allowing for analysis of metabolic parameters after drug withdrawal and reintroduction. The investigator's aim, ultimately, is to determine the mechanisms of weight gain so that future interventions can more effectively reduce ART-related weight changes.
Source link: https://clinicaltrials.gov/ct2/show/NCT04495348
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