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However, there are no studies on BoNT's effectiveness in Parkinson's disease or atypical parkinsonism, and no comparison of BoNT's effectiveness has been made between these diseases and the different localizations of dystonia in these pathologies. The results of 611 BoNT injections in 63 dystonic parkinsonian patients using a self-reported clinical improvement scale and duration of effect were collected retrospectively from patients' medical records. Patients with PD and AP improve after BoNT injection, according to a scale from 0 to 100, and it is roughly similar to different localizations of dystonia. Overall, our findings point to BoNT's use in a number of dystonic conditions associated with degenerative parkinsonian syndromes. In AP compared to PD, shorter delays between injection sessions should be factored in, rather than PD. Trial registration: This study was published on Clinicaltrial. gov.
Source link: https://doi.org/10.1007/s00415-022-11280-y
We spotlight a patient with SCA21, who had myoclonus dystonia syndrome and whose dystonia had a modest reaction to levodopa. Affected family members of the affected family members had a similar phenotype. The TMEM240 mutation in patients with M-D syndrome is shown by this case, which emphasizes the importance of genetic testing in patients with M-D syndrome and supports the trial of levodopa for patients with dystonia SCA21.
Source link: https://doi.org/10.1212/WNL.0000000000201015
Deep brain stimulation is the most cost-effective treatment for medically refractory dystonia with globus pallidus internus being the most common target. Despite the overall success of DBS in dystonia, there is still considerable variability in treatment outcomes in both short and long-term follow-ups, due to several causes. Brain target, stability of lead placement, stimulus parameters, time allowed for response, neurostimulation techniques, and DBS-induced side effects are among the 'DBS dependent' variables that can influence 'DBS related' factors, including brain measurement, accuracy, lead placement, stimulation parameters, time allowed for response, and DBS-induced side-effects.
Source link: https://doi.org/10.1097/WCO.0000000000001072
Hyperkinesias are caused by a variety of brain regions and relatively undefined pathophysiological mechanisms. We mostly refer to human studies that use surface and invasive in-depth recordings, as well as spinal, brainstem, and transcortical brain stimulation methods, as well as non-invasive brain stimulation methods. Pathophysiological studies can determine the extent to which hyperkinesias' neurophysiological abnormalities can be explained by pathophysiological techniques. Hyperkinesia's clinical context also addresses the potential role of neurophysiological assessment in the clinical context.
Source link: https://doi.org/10.1016/j.clinph.2022.05.014
Fifteen patients with cervical dystonia and good outcome after pallidal deep brain stimulation underwent resting-state functional magnetic resonance imaging under three conditions: stimulation using a priori clinically established optimal settings, non-optimal settings, and stimulation off. When this model included four new patients with generalized or truncal dystonia, the relationship remained stable.
Source link: https://doi.org/10.1002/ana.26450
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