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Dystonia - ClinicalTrials.gov

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Last Updated: 25 July 2022

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Cholinergic Receptor Imaging in Dystonia

Dystonia is a heterogeneous group of mobility disorders characterized by abnormal muscle contractions resulting in abnormal postures and movements. Crytonia is an example of a focal dystonia. Microstructural changes in the basal ganglia have been found in voxel-based morphometry and diffusion tensor imaging, and abnormal basal ganglia metabolism has been detected in imaging with fluorodeoxyglucose positron emission tomography in various forms of dystonia, according to neuroimaging studies. From animal model studies, there is now evidence pointing to the basal ganglia in dystonia. An abnormality in cholinergic neurotransmission has also been observed, owing to a medical reaction to antimuscarinic medications. Although antimuscarinic drugs are helpful in the symptomatic treatment of dystonia, dystonia's symptoms, the role of muscarinic acetylcholine neurotransmission in dystonia is uncertain. Population Study We want to evaluate one group of patients with a form of primary dystonia to be compared to healthy volunteers without history of neurological or major psychiatric disorders. The central hypothesis will be tested using a neuroimaging technique, position emission tomography, for cervical dystonia as determined with PET using [18F]FP-TZTP. Outcome Measures This research will determine cholinergic neurotransmitter receptor binding in patients with cervical dystonia compared to healthy controls. This planned research study is intended to advance our knowledge of dystonia's pathophysiology in order to identify potential targets for future pharmacological therapies in dystonia and monitor disease progression.

Source link: https://clinicaltrials.gov/ct2/show/NCT02689466


Investigations of Pathophysiology of Focal Hand Dystonia

Patients with FHD and Healthy Volunteers will be included in the study. In the various conditions, we'll investigate the differences in BOLD signals in the parietal lobe, in FHD compared to HVs. We will use vascular occupancy imaging to explore differences in the lack of detailed cortical mapping of neural networks among FHD and healthy volunteers. The Physiology experiments aim to look at abnormalities and differences in baseline motor cortical excitability among the two groups' baseline motor cortical excitability levels and evaluate the effects of continuous Theta Burst Stimulation on these steps. Physiology findings: Baseline differing influence of PMv and IPL on motor cortical excitability and changes after dIPL's cTBS. Baseline cortical Silent Period in the affected and uninvolved limb in FHD and the effect of cTBS on cSP in the affected leg.

Source link: https://clinicaltrials.gov/ct2/show/NCT03223623


Deep Brain Stimulation Effects in Dystonia: Time Course of Electrophysiological Changes in Treatment

By a small case study, potential abnormal brain signals, such as high blood pressure in the ta band, have been suggested. The introduction of newer technologies has helped clinicians and researchers alike to better understand the pathophysiological underpinnings of various disorders treated with neuromodulation. A small case study has identified potential abnormal brain signals, such as high blood pressure in theta band, as well as high blood pressure in the Ta band.

Source link: https://clinicaltrials.gov/ct2/show/NCT04568681


Multicenter Evaluation of Deep Brain Stimulation for Idiopathic Craniofacial Dystonia: Globus Pallidus intErnus or Subthalamic Nucleus

Patients with idiopathic craniofacial dystonia (STN-DBS): Evaluating the therapeutic effects of GPi-DBS vs. STN-DBS on patients with idiopathic craniofacial dystonia may have different treatment time points will be collected, according to different clinical studies. STN-DBS is non-inferior to GPi-DBS for motor function improvement in patients with idiopathic craniofacial dystonia (PCT) for 365 days postoperatively in patients with a 365-day postoperatively. Differences between the two groups in BFMDRS-M change scores in the stimulus state vary from before to 365 days after STN-DBS and GPi-DBS were announced.

Source link: https://clinicaltrials.gov/ct2/show/NCT05416905


Propensity to Develop Plasticity in the Parieto-motor Network in Dystonia From the Perspective of Abnormal High-order Motor Processing

We hypothesize that dystonic patients have increased sensitivity to plasticity induction in the parieto-motor network. The plasticity results of such a high plasticity will be evaluated by correlating the plasticity measurements with subjects' results on two tasks involving high-order motor processing and paralocating the parietal cortex. In each study, there will be two independent arms: one will compare patients with writer's cramps and age-matched healthy volunteers; the other one will compare cervical dystonia patients with age-matched HVs. Hence, we require a maximum of 20 patients per patient group and 40 subjects for the control groups. One screening visit and two outpatient study visits will be held for one screen visit and two outpatient lab visits. Patients will be assessed scientifically for dystonia during the first study visit. TMS will be released at least 24 hours later, during a second study visit. As motor evoked potentials, TMS-induced electromyographic activity of hand muscles will be recorded. We will track the input-output curve for the right first dorsal interosseous muscle MEPs using single TMS shocks. The posterior parietal cortex and the primary motor cortex will be linked by a plasticity induction procedure aimed at inducing plasticity in the pathway connecting the posterior parietal cortex and the primary motor cortex. Transcranial stimulation will be applied consistently to the left angular gyrus in the PP cortex and the left M1 to that end. Using a T test, the difference in MEP size would be calculated between the HV and the patient groups.

Source link: https://clinicaltrials.gov/ct2/show/NCT02504905


An Open-Label, Multicenter Study to Evaluate the Safety and Efficacy of Repeat Intramuscular ABP-450 (prabotulinumtoxinA) Injection for the Treatment of Cervical Dystonia

This Open-label Extension trial will determine the safety and effectiveness of ABP-450 for adults with cervical dystonia. All study participants, regardless of treatment allocation, will be eligible to enroll in this OLE study.

Source link: https://clinicaltrials.gov/ct2/show/NCT04871451

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions