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Retraction syndrome in Isolated Duane is a result of eye mobility. The eyelids are partially closed as the eyelids move inward, and the eyeball pulls back into its socket as the eyelids retracts. About 10% of people with isolated Duane retraction syndrome experience amblyopia, a condition that causes vision loss in the affected eye. About 70% of all cases of Duane retraction syndrome are isolated, which means they have no signs or symptoms that are not apparent. Duane retraction syndrome can also be a symptom of conditions that affect other areas of the body.
Duane anomaly restricts outward eye movement and, in some cases, can restrict inward eye movement, and can restrict inward eye movement. Also, as the eye moves inward, the eye opening becomes narrower, and the eyeball can pull back into its socket. These hand and arm abnormalities are common as radial ray malformations when considered together. People with a combination of Duane anomaly and radial ray malformations may have a variety of other signs and symptoms. Duane-radial ray syndrome's numerous signs and symptoms often overlap with those of other disorders. Based on these similarities, researchers conclude that Duane-radial ray syndrome and acro-renal-ocular syndrome are two related disorders with numerous common signs and symptoms. Both the symptoms of a disorder called Holt-Oram syndrome are similar to those of a Holt-Oram syndrome; however, these two disorders are characterized by mutations in different genes.
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