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Purpose: The aim of this study was to determine the effects of a thermo-mechanical action-based peri-orbital fractional skin therapy on dry eye disease. Comprehensive ophthalmic examinations, including the Ocular Surface Disease Index questionnaire, non-invasive tear break-up time and tear osmolarity, as well as detailed ophthalmic findings, were used to evaluate vision, intraocular pressure, and dry eye symptomatology. The Tixel treatment was associated with clinically and statistically significant improvement in the DED symptoms, which was aided by a decrease of 21. 40 u00b1 15. 08 of the OSDI index. In the Andorra cohort, non-invasive tears broke-up time increased by 2. 10 s in the Birmingham cohort and 6. 60 s by 2. 13 s. Conclusions Tixelu00ae may be an attractive, safe, and effective treatment for DED. This therapy has been associated with significant improvement in DED signs and symptoms in both clinical and statistically significant improvements in DED signs and symptoms in this population with no adverse events.
Source link: https://europepmc.org/article/MED/36635105
Historical studies have reported that Korean red ginseng extract has antipruritic properties, which can be attributed to the presence of Rg3, one of the most potent ginsenosides. The present study was conducted to determine the effects of Rg3EKRG in acute chloroquine-induced and chronic dry skin pruritus. Methods The calcium imaging method was used in HE293T cells expressing MrgprA3 and TRPA1 as well as in primary cultures of mouse dorsal root ganglia neurons. On dry skin models, mouse scratching behavior tests were carried out. MrgprA3 mRNA levels increased, as shown by DRG neurons obtained from dry skin mice models, and Rg3EKRG therapy improved chronic dry skin disease conditions and reduced spontaneous scratching behaviors. Conclusion Rg3EKRG has a greater antipruritic action than KRG, inhibiting both acute CQ-induced and chronic dry skin pruritus in a MrgprA3-dependent manner, according to the present study.
Source link: https://europepmc.org/article/MED/36632132
New agents and combination therapies that target oxidative stress, as well as other characteristics of dry and sensitive skin have been shown to have positive effects on clinical outcomes in infants with dry and sensitive skin. We reviewed scientific registration studies of products that have been shown to reduce skin dryness in cosmetically acceptable ways in this paper. Overall, similar strategies may be investigated to improve the administration of dry skin in all age groups in order to ensure greater consistency in reaching treatment goals.
Source link: https://europepmc.org/article/MED/36537673
In mammals, sensations of buccal food and drying have immediate results on postprandial hunger to prevent future systemic dehydration, and are hence termed as a 'anticipatory thirst. ' Those mudskippers migrated into water areas within a minute after terrestrial eating and displayed rolling movements with accompanying pectoral-fin movements. Migration into a water area for drinking increased within a few minutes after eating onset, without systemic dehydration.
Source link: https://europepmc.org/article/MED/36477197
V channel 1 and A member 1 are two primary receptors for peripheral neural coding of itch sensory, mediating histaminergic and nonhistaminergic itch separately. The key facilitating factor for dry-skin-related chronic itch, according to our findings, TMEM100 protein in DRG is the leading triggering factor for dry-skin-related chronic itch, and targeted elimination of TMEM100 in DRG may be a novel treatment option for patients with dry skin-induced itch.
Source link: https://europepmc.org/article/MED/36514220
According to previous studies, CST6 may play a key role in epidermal differentiation and hair follicle formation by inhibiting the production of specific cognate target proteases. The mutant cystatin M/E protein, which had no effect on cathepsin's protease enzyme activity, was shown in further fluorimetric enzyme assays. In conclusion, the homozygous missense mutation c. 251G > A in the CST6 gene resulted in dry skin, desquamation, as well as abnormal keratosis of the skin, increasing our knowledge of the role of protease-antiprotease balance in human skin disorders.
Source link: https://europepmc.org/article/MED/36371786
Although recent evidence supports the use of dry needling for improving some clinical outcomes in people with neck pain, no new studies has looked at the effects of dry needling on the central nervous system in this population. Therefore, this clinical trial sought to compare the effects of real and sham dry needling on autonomic nervous system function, pain processing, as well as clinical and psychological characteristics in patients with chronic nonspecific neck pain. Our findings indicated that dry needling applied to patients with chronic nonspecific neck pain resulted in an immediate decrease in mechanical hyperalgesia at local hospitals and resulted in an increase in skin conductance relative to sham needling.
Source link: https://europepmc.org/article/MED/36431093
For wearable healthcare surveillance, clinical diagnosis, and human-machine interactions, on-skin patches that record biopotential and biomechanical signals are highly recommended. To get wearing comfort and high-quality signals, patches with tissue-like smoothness, elastic recovery, damage tolerance, and a robust bioelectronic interface are highly sought but impossible to achieve. We present a dry epidermal patch made from a supramolecular polymer and a percolation network in situ transferred carbon nanotubes. Multiple dynamic interactions embed the polymer's hybrid structure, which gives the desired mechanical response change from elastic recoil to energy dissipation with increased elongation.
Source link: https://europepmc.org/article/MED/36318185
Senior citizens' dry skin and pressure injuries have exacerbated global health care challenges. Patients with dry skin had more pressure ulcers than those with dry skin. Patients with extremely dry skin had more pressure injury risk and a higher risk of Stage 2+ pressure injury. Other nine forecastors were concerned with total pressure injury and stage 2+ pressure injuries, while nine others were associated with overall pressure injuries and stage 2+ pressure injuries. 91 and 0. 91, respectively, in the area under receiver operating characteristic curve of the predictive models of overall pressure injuries and stage 2+ pressure injuries.
Source link: https://europepmc.org/article/MED/36307094
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