Drug Development - BioRxiv

Alterations in excitatory and inhibitory synaptic development within the mesolimbic dopamine pathway in a mouse model of prenatal drug exposure

In spite of having a better understanding of NAS and its signs and symptoms, there still continues to be a lack of details surrounding the long-term impacts of prenatal exposure to medications of misuse on neurological development. The goal of this research study was to check out the effects of prenatal drug exposure on synaptogenesis within brain regions related to the mesolimbic dopamine pathway, the main incentive path within the brain connected with drug misuse and dependency, in an expectant mouse design. Immunohistochemistry and confocal fluorescence microscopy imaging studies on the brains of postnatal day 21 mouse puppies revealed a considerable increase in the mean variety of excitatory synapses within the anterior cingulate cortex, nucleus accumbens, and prefrontal cortex in mice that were prenatally revealed to either the opioid drug buprenorphine or gabapentin.

Source link: https://doi.org/10.1101/2020.12.18.423503

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