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In addition, the dosimetry of the acquired images was assessed both in the SV function alone and as well as in a complete tomographic image in two separate fields of view. The thermoluminescent dosimeters were irradiated within the FOV and analyzed in a portable reader for dose analysis. Three specimens of gutta-percha stick were placed on the same device as the CT scans were obtained in three different regions of the mouth, simulating various regions of the mouth. With the use of SV, there was a marginally rise in the radiation dose. In the images obtained without SV, the distances were noticeably larger. Every image obtained with SV was categorized as being at the FOV's center. In conclusion, the results showed that the SVs function is able to centralize the ROI in the FOV, improving the scan accuracy and avoiding repetitions due to positioning mistakes.
Source link: https://doi.org/10.1590/0103-6440202204926
Two isotopes are used to determine radiation dosimetry for a therapeutic radiopharmaceutical from a diagnostic imaging study with the same tracer molecule labelled with an isotope more suitable for the imaging process. We describe the change of radiation dosimetry from the diagnostic radioiodine isotope 123I, which is coded for the hypoxia tracer molecule iodoazomycin arabinoside, to isotopes 131I and 124I. These results are used here to determine residence times for 131I and 124I as well as their uncertainties. Physical decay and physical decay are two specific instances when extrapolating to infinity: purely physical decay and physical decay plus biological washout. For case A, uncertainty was similar to 123I in case A, but for case B, it was much higher, particularly for long-lives. When switching between isotope species and IAZA, standard tissue dosimetries for IAZA must be considered closely. These findings are particularly relevant when considering PET imaging studies in [124I]IAZA or therapeutic administration of [131I]IAZA.
Source link: https://doi.org/10.3390/pharmaceutics14081655
We reviewed the safety and human radiation dosimetry of 64Cu-LLP2A here for use in MM patients. Participants under the supervision of tracer biodistribution, pharmacokinetics, and radiation dosimetry were among the six healthy participants underwent 64Cu-LLP2A-PET/CT/MR or PET/MR scans up to three time points to help determine tracer biodistribution, pharmacokinetics, and radiation dosimetry. Using the Organ Level INternal Dose Assessment software, mean organ absorbed doses and effective doses were calculated. Male and female CD-1 mice showed a 150-fold mass excess of the recommended imaging dose was digested well. The maximum organ uptake in humans was 0. 36 mSv/MBq, with spleen having the highest organ uptake of 0. 142 mSv/MBq. The red marrow had the longest residence time among all tissues, according to all tissues. Image quality evaluations support early imaging time as optimal. Cell experiments showed statistically significant blocking for the tracer used for all of the human experiments.
Source link: https://doi.org/10.2967/jnumed.122.264349
Quartz extracted from fired materials has been used for retrospective dosimetry for nearly 40 years. Optically stimulated luminescence has been used for retrospective dosimetry for over 40 years. Quartz's sensitivity to thermoluminescence and optically stimulated luminescence can vary by several orders of magnitude. Quartz has been extracted from bricks made by three different companies in the Czech Republic. Quartz was extracted from fired bricks as well as from the bricks before firing, as well as from the bricks. After the firing process, significant shifts in quartz sensitivity were observed. After repeated irradiation exposures, Sensitivity has also increased.
Source link: https://doi.org/10.1093/rpd/ncac111
For the establishment of the TG-51 protocol for reference dosimetry of external high-energy photon and electron beams, practical guidelines that are not specific in the TG-51 protocol and its Addendum for photon beam dosimetry are included.
Source link: https://doi.org/10.1002/mp.15949
We investigate the capabilities of a light emitting diode flatbed scanner for use with EBT3 and EBT-XD film types in a clinical radiochromic film dosimetry program with modern treatment techniques. The flatbed scanner was described as characterized by lateral and longitudinal response, X-Y scaling accuracy, scanning reproducibility, scanner warm up tolerance, and film orientation dependence. For the LED light source, the most appropriate lateral response artefact corrections are investigated. Four patient care therapies were compared between the latest 12000XL and the old 10000XL model in the 2D gamma study. It can be argued that the lateral response variation correction adjustment needs to be addressed, but longitudinal response variations are insignificant. When the necessary adjustments are made, results are indistinguishable for both film types across the two scanner models, according to a comparative gamma review of patient specific dose maps between the EPSON 10000XL and 12000XL scanners.
Source link: https://doi.org/10.1007/s13246-022-01161-z
In the present research, which focused on the improvement of crystalline lattice and the lead graphite structural defect caused by an electron irradiation dose ranging from 0. 5 to 20 Gy delivered by an Elekta HD Linac, different thicknesses of 2B grade polymer pencil lead graphite were used. Using the initial rise and peak shape approaches of the PPLG samples exposed to 20 Gy, the kinetics order, activation energy, and frequency factor of the PPLG samples were determined using the PPLG samples's frequency factor and frequency sensitivity. The TL glow peak's lifetime is also included in this series, which gives information on the TL signal's stability at maximum temperatures. The findings of this line of study are intended to inspire the development of flexible graphite radiation dosimeters as a low-cost effective method for radiation detection.
Source link: https://doi.org/10.1016/j.apradiso.2022.110419
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