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Dosimetry - DOAJ

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Last Updated: 03 September 2022

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A Detailed Analysis of the H.B. Robinson-2 Reactor Pressure Vessel Dosimetry Benchmark

Many nuclear pressurized water reactors are being extended beyond their intended lifetime limit, according to the operator. Therefore, the quantification of the neutron irradiation embrittlement of the reactor pressure vessel is an important feature, because it is a determining parameter that influences the reactor lifespan. The VACS' determination of the full-core fission neutron source term and a Monte Carlo simulation scheme to simulate neutron attenuation from the center to areas of concern are two components of a deterministic approach. When the ENDF-B/VII. 1 or JEFF-3. 3 numeric data libraries are used in the attenuation estimation, VACS displays acceptable accuracy, according to the study.

Source link: https://doi.org/10.3390/en15145098


Characterization of Thermoluminescent Dosimeters for Neutron Dosimetry at High Altitudes

Neutrons make up a substantial portion of the secondary cosmic rays and are one of the most important contributors to natural cosmic ray radiation background doses. The study of the cosmic ray neutrons' contribution to the dose equivalent received by humans is an exciting and challenging challenge for the scientific community. The aim of this study was to describe the thermoluminescent dosimeter at high altitudes for long-time neutron dose monitoring because the dose rate due to cosmic radiation rises strongly with altitude. Due to the current difference in 6Li isotope concentrations, a pair of TLD-700 and TLD-600 is especially used to obtain the data on gamma and neutron dose in mixed neutron-gamma fields. In an experimental setup using a 241Am-B radionuclide neutron source coated with a moderator material, polyethylene, a thermalized neutron field was calibrated in terms of neutron ambient dose equivalent.

Source link: https://doi.org/10.3390/s22155721


Personalized Dosimetry in the Context of Radioiodine Therapy for Differentiated Thyroid Cancer

Differentiated Thyroid Cancer, which accounts for more than 90% of cases, is the most common thyroid cancer. The systemic administration of 131-sodium or potassium iodide is a suitable option for the treatment of DTC. Due to its connection to tissue irradiation reactions, the Absorbed dose is a reliable indicator of biological response. This paper seeks to summarize current evidence for a dosimetry-based therapy and, in turn, investigate new alternatives that may have the ability to produce more specific therapies, minimizing the risk of differential thyroid cancer treated with radioiodine therapy.

Source link: https://doi.org/10.3390/diagnostics12071763


Evaluation of Alpha-Therapy with Radium-223-Dichloride in Castration Resistant Metastatic Prostate Cancer—the Role of Gamma Scintigraphy in Dosimetry and Pharmacokinetics

Radium-223-dichloride, a new bone-seeking calcium analogue alpha-emitter, has received marketing approval for the treatment of skeletal metastases of hormone-refractory prostate cancer. To determine dosimetry in tumors and determine potential pharmacokinetic variations in the treatment cycles, we analyzed two patients using quantitative serial gamma imaging to identify dosimetry in tumors. Despite poor gamma activity at 0, 7, 28, and 28 days using 30u201360 min acquisition times, the lesions were rather well represented in gamma scintigraphy. Both our patients who were analyzed in serial gamma imaging had two lesions in the gamma imaging field, and the mean intensity varied from 27. 8 to 382. 2, and from 37. 4 to 82. 2. The maximum difference between the treatment cycles in the same lesion was 2. 0-fold, according to the imaging. Patient 1 had a serum PSA response, while patient 2 had no PSA response, while patient 2 had no PSA response. From our results, there were maximally up to 4. 0-fold differences between the relative absorbed radiation doses between patients as determined by quantitative standardized imaging to be released in just two lesions, and in the same lesion the maximum difference in the cycles was up to 2. 3 fold. Both our patients had two metastatic sites in the imaging field; the former patient had a serum PSA response, but there was no PSA response; the latter had no PSA response.

Source link: https://doi.org/10.3390/diagnostics5030358


First-in-Human Study of [ 68 Ga]Ga-NODAGA-E[c(RGDyK)] 2 PET for Integrin α v β 3 Imaging in Patients with Breast Cancer and Neuroendocrine Neoplasms: Safety, Dosimetry and Tumor Imaging Ability

During angiogenesis and on tumor cells, the subtype integrin u03b1 vs. u03b2 3 is upregulated on endothelial cells, according to the subtype integrin u03b1 vs. u03b3b1 vs. u03b2 3 is upregulated on endothelial cells. Integrin in vivo analysis is also feasible with positron emission tomography. We examine [ 68 Ga]Ga-NODAGA-E[c] 2 PET in patients with neuroendocrine neoplasms and breast cancer in this first-in-human phase I study. PET images were analyzed for tracer uptake in tumors and background organs. This first-in-human phase I trial showed safe use of [ 68 Ga]Ga-E[c] 2 for integrin vs. u03b1 in cancer patients, low radiation exposure, and positive tumor uptake in tumors. [ 68 Ga]Ga-NODAGA-E[c] 2's early identification of patients suitable for procedures affecting integrin [u03b1 vs. u03b2 3 and patient risk stratification are encouraged, and further research is required to determine whether [ 68 Ga]Ga-NODAGA-E[c] 2 may be a tool for early identification of patients enrolled in therapies vs. u03b1 [b] 2 and for patient risk stratification of patients u03b1 e[c] 2 [b1 v] 2 [g] 2[c] 2 [Ga] 2 [Ga] 2 [c]2] 3 and risk stratification [C] 2 [C] 2 [c] 2u03b1 vse[c]2 [ u03b1 vst b1 e[c]2[c] 2[c]2b1]2/3b1 vsye[c] 2[c] 2[c]2] 2[c] 2;.

Source link: https://doi.org/10.3390/diagnostics12040851


Comparison of Dosimetry Protocols for Electron Beam Radiotherapy Calibrations and Measurement Uncertainties

This paper contains recommendations for the calibration of radiation beams developed by the International Atomic Energy Agency, the American Association of Physicists in Medicine, and the German task group. This research seeks to establish uncertainties in dosimetry for electron beam radiotherapy using internationally recognized high-energy radiotherapy beam calibration methods. The ratio between TRS 388 and 1. 004 was found to vary between 0. 88 and 1. 004 for the predecessor TRS 398/DIN 6800-2 and TG 51/DIN 6800-2, respectively, with respective variations 0. 991 and 0. 997. Dose intercomparisons between radiotherapy centers can be facilitated by the use of the recently established dose conversion factors for all three protocols, according to it.

Source link: https://doi.org/10.3390/life12010031


Assessment of in vitro particle dosimetry models at the single cell and particle level by scanning electron microscopy

Abstract Background Particokinetic models are necessary to predict the safe cellular dose, which is vital to understanding particle interactions with biological systems. Here, we used high resolution scanning electron microscopy to measure particle counts on cellular and intercellular surfaces and compare experimental results with ISDD and DG models' predictions. Result The exposure of human lung epithelial A549 cells to a variety of silica particles in a remarkably higher dose was found on intercellular regions in comparison to cellular surfaces. When a high adsorption to the surface was imitated, both the ISDD and DG models correctly predicted particle densities in the intercellular space. Surface properties with respect to adhesion and desorption can be used to improve modeling methods, allowing the cellular dose to be forecast with greater precision.

Source link: https://doi.org/10.1186/s12951-018-0426-2


Gamma Radiation Dosimetry Using Tellurium Dioxide Thin Film Structures

When the radiation dose was elevated, the optical band gap values were reduced, according to it. With the rise in radiation doses up to a certain dose level, samples with electrical contacts having a planar structure showed a linear increase in current values. Dosimetry of room temperature vs. u00c3Adno meter The observed changes in both the optical and electrical properties indicate that TeO2 thin film can be considered as a useful product for room temperature measurement.

Source link: https://doi.org/10.3390/s20800347

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions