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This research is concerned about determining the bulk and tablet dosage forms of Dolutegravir by using a new yet simple spectrofluorimetric device that exhibits rapid response and high sensitivity in comparison to those using HPLC techniques and the lower sensitivity spectrophotometric ones. After excitation at 262 nm, the method relies heavily on testing the native fluorescence of Dolutegravir in water.
The study of drug impurities is a critical area of process research and development. In the current study, two diastereomeric impurities, R,R- and S,S-isomers of recently approved antiretroviral drug dolutegravir were investigated. The ethyl 5--3-ethyl 5--3-oxo-4-oxo-1--1,4-dihydropyridine-2-carboxylate is a pyridine 2-carboxylate derivative that is used in ethylene synthesis. To produce the desired target compound in high yield, the protocol involved individual treatment of this common ester with - and -3-amino-1-butanol. The latest report will be of utmost importance to researchers involved in the process of finding chemically pure dolutegravir.
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