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Disseminated intravascular coagulation as a complication of surgery for ventriculoperitoneal shunts is extremely unusual, and only one case has been reported in the literature. The authors explore the case of a 9-year-old girl with shunted hydrocephalus who appeared with a 3-day history of headaches and vomiting in the case. Ventricles had enlarged ventricles as compared to baseline, according to A head CT. The patient became apneic and progressed to cardiopulmonary arrest immediately after extubation. The patient died on postoperative Day 1 on postoperative Day 1, and autopsy results revealed DIC. If excessive bleeding occurs after any brain injury, disseminated intravascular coagulation should be considered.
Source link: https://doi.org/10.3171/2009.10.peds0974
Abstract aims u2014 To find any correlation between subclinical DIC diagnosis and the onset or occurrence of colitis in horses, colitis, and to determine any connection between the diagnosis of subclinical DIC and occurrence of colitis in horses. U201437 horses were admitted to a veterinary teaching hospital for acute colitis therapy. At the time of sampling, no horses had clinical signs of DIC. Five of the 12 horses with subpoena DIC and two of 25 horses without subpoena DIC did not recover, and two of 25 horses with subtopic DIC did not recover. According to a Crude odds ratio analysis, a horse with acute colitis was eight times more likely to die or be euthanized if a diagnosis of subclinical DIC was made. Conclusions and Clinical Relevance:u2014Clinicopathologic evidence of DIC is widespread and is strongly associated with a poor outcome in horses with acute colitis. Chronic colitis in horses can be influenced by subcutaneous DIC therapy.
Source link: https://doi.org/10.2460/javma.2002.220.1034
u2014All healthy dogs had negative cD-d POC test findings, with the same mean cD-d ELISA value of 0. 2 U/mL. Positive cD-d POC test findings and mean cD-d ELISA value of 44 U/mL for all dogs with DIC. The mean cD-d ELISA value of 34 U/mL was reported by 17 of 19 dogs with acute TED, and 17 of 19 had positive cD-d POC test findings. Mean cD-d POC test findings in dogs with hemorrhage were 14 units/mL, and 15 of 18 had positive cD-d POC test findings. The cD-d ELISA values in dogs with hemorrhage were much higher than those of healthy dogs, but not lower than those of dogs with DIC and acute TED. u2014's Findings and Clinical Relevance The cD-d POC test kit can be quickly and conveniently used, and can detect dogs with DIC or acute TED. Positive results can also be seen in dogs with internal hemorrhage.
Source link: https://doi.org/10.2460/ajvr.2003.64.1562
Objectives - U2014 is a game set "u2014" to determine the sensitivity and specificity of assays of D-dimer concentrations in dogs with disseminated intravascular coagulation and healthy dogs, assays, assays of serum and plasma fibrinogen degradation product assays. animals are healthy and happy dogs in U201420/20/20 dogs with DIC and 30 healthy dogs. Conclusions The study range for the immunoturbidometric D-dimer concentration in assay was 0. 08 to 0. 39 g/ml; median concentrations were significantly higher in dogs with DIC than in healthy dogs. At the 0. 39 g/ml cutoff, the immunokinetic assays had similar sensitivity and specificity, assays for latexagglutination D-dimer, serum and plasma FDP assays; the immunokinetic assay had lower sensitivity and specificity at the 0. 30 g/ml cutoff and lower sensitivity at the 0. 39 g/ml cutoff. Specificity of D-dimer concentrations in dogs with systemic disease other than DIC has not been established, so FDP and D-dimer assays should be performed simultaneously as supporting tests for the diagnosis of DIC in dogs.
Source link: https://doi.org/10.2460/ajvr.2000.61.393
Abstract: Disseminated intravascular coagulation is a condition that can be characterized by systemic activation of coagulation, potentially leading to thrombotic blockage of small and mid-size vessels, contributing to organ dysfunction. At the same time, continued intake of platelets and coagulation proteins has resulted in thrombocytopenia and low clotting factors, which may cause profuse hemorrhagic dysfunction. Administration of platelet concentrates, plasma, or coagulation factor concentrates should be considered in patients with significant bleeding or at risk of hemorrhagic events.
Source link: https://doi.org/10.1182/blood-2017-10-804096
In conditions such as sepsis and trauma, chronic disease with disseminated intravascular coagulation is an acquired disease that occurs as a result of systemic and chronic cell injury. Poor understanding and recognition of the intricate interactions involved in the coagulation, fibrinolytic, inflammatory, and innate immune pathways have resulted in poor control and high mortality rates in DIC. This essay discusses significant recent advancements in our knowledge of DIC pathophysiology. In particular, circulating histones and neutrophil extracellular traps meet established criteria for DIC pathogenesis.
Source link: https://doi.org/10.12688/f1000research.12498.1
Spine surgeons outside of deformity or severe trauma cases are unlikely to encounter disseminated intravascular coagulation by spine surgeons outside of deformity or severe trauma patients. Several en plaque thoracic meningiomas in a patient with neurofibromatosis type 1 during elective resection of multiple en plaque thoracic meningiomas in a patient with neurofibromatosis type 1. For the resection of multiple en plaque meningiomas for thoracic myelopathy, a 49-year-old man underwent T1-u20133 laminoplasty and expansile duraplasty. Despite massive transfusions of blood products, the patient was discovered to be in a state of DIC that did not resolve postoperatively. A wound VAC can be used with exposed dura if deemed appropriate by the surgeon; however, the number and characteristics of the procedure should be closely monitored. Unconventional surgical techniques may be able to reduce the morbidity associated with spine surgery's refractory DIC.
Source link: https://doi.org/10.3171/2019.7.spine19756
Disseminated intravascular coagulation is a condition that is characterized by systemic intravascular coagulation of coagulation, resulting in widespread fibrin deposition in the circulation. Nevertheless, a combination of widely available tests may be helpful in diagnosing DIC and aiding in the selection of DIC patients that need specific, often expensive, intervention in the coagulation process. Latest research on key pathogenetic pathways that may lead to DIC has resulted in novel preventive and therapeutic approaches to patients with DIC.
Source link: https://doi.org/10.1093/med/9780199600830.003.0270
Hypofibrinogenemia patients with hypofibrinogenemia were particularly high in both bleeding and organ failure symptoms, as well as organ failure or the DIC diagnostic criteria, meaning that in patients with infectious disease patients with hypofibrinogenemia is correlated with more frequent and severe DIC diagnostic syndromes. Although the 28-day survival rate and the DIC resolution rate were both significantly lower in infectious disease patients with hypofibrinogenemia and those without hypofibrinogenemia, this difference was not present in DIC patients with hematological disorders.
Source link: https://doi.org/10.21203/rs.3.rs-86887/v1
u2713 A child who started general bleeding immediately after the placement of a ventriculoperitoneal shunt was discovered to have signs of disseminated intravascular coagulation. Intraventricular hemorrhage, a reduction of half of the red cell volume to subcutaneous tissues, and transient peritoneal inflammation were among the complications of the acute bleeding episode. If excessive bleeding occurs after any brain injury, the diagnosis of DIC should be considered early and recoverable hemostasis by replacement of clotting factors can help avoid major complications related to continuing hemorrhage.
Source link: https://doi.org/10.3171/jns.1981.54.2.0264
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