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Background: Dietary supplementation is a common tactic to achieve a particular health condition or performance benefit. The aim of this research was to outline the use of dietary supplements in Iraqi genders. Patients and Methods: Many questions regarding dietary supplement use were raised as a result of a single study that included 112 female and 247 women aged 35–74 years old in 2021. n = 359 -reported the frequency and use of supplement use by sex and type of drug use in 2021. The mean percentage of dietary supplement use in female and male figures varied among female and men. In women than in men, the use of sex was higher than in men. Herbals use in females are more popular than male. Conclusions: This report shows that there are substantial differences in vitamin use in Iraq, which could have a direct and population nutrient intakes. Abstract Background: Abstract Background: Dietary supplementation is a common tactic to achieve a specific health condition or performance benefit. The aim of this research was to report the use of dietary supplement in Iraqi genders. Patients and Methods: Many questions regarding dietary supplement use were asked as part of a single study on 112 female and 247 women aged 35 to 4 years in 2021, a number that was a part of a large study that included sex and type of supplement used by gender and gender. The mean percentage of dietary supplement use varied among female and males, according to the findings: the mean percentage of dietary supplement use varied between female and male. Herbals use in female rather than male. Conclusions: This report shows that supplement use in Iraq is highly variable, affecting individual and population nutrient intakes.
Obesity and overweight are metabolic diseases related to oxidative stress and are risk factors for several chronic diseases. In a high-fat diet-induced overweight rat model, we wanted to investigate the effects of Metaswitch dietary supplement on weight gain and associated acute metabolic changes. Methods: The female Sprague Dawley rats were divided into 6 groups. HFD treatment groups on HFD have been treated with three different daily doses of Metaswitch for three weeks. Slimrite®, a common drug, was a sample drug by another group on HFD. Rats on HFD also received cyproheptadine to boost appetite. Rats on HFD gained significant body mass in comparison to rats exposed to NCD. Among the groups, there were no significant changes in the serum lipids and glucose levels. Conclusions: In female SD rats, a 3-week HFD diet with cyproheptadine supplementation resulted in a significant increase in body weight and acute metabolic alterations, as shown by the graph.
Source link: https://doi.org/10.1016/j.biopha.2022.112892
Abstract Background : Diabetes has already pose a threat to the nation and the individual due to high prevalence rates and high medical expenses. PURIAM110, a mixture of orange fruits and mulberry leaves, is intended to stop type II diabetes mellitus progression and diabetes related disorders in particular. This is the first reported pilot study into the protective effects of the orange fruits and mulberry leaves mixture against pre-diabetes in Korean adults. Supplement-based research of dietary supplements must be conducted in order to demonstrate consistent findings based on these promising findings of herb-derived ingredients. Design Methods/Design PURIAM110's efficacy and safety review is a double-blinded, placebo-controlled, randomized, and multi-center clinical trial. This study will last 6 weeks and will enroll a total of 45 participants. In addition, PURIAM110 can serve as an alternative dietary supplement to diabetics.
Source link: https://doi.org/10.1186/1745-6215-12-38
Background: Although many health care professionals in the United States have been trained to and recommend dietary supplements, little is known about their personal use of diet supplements and the usage that goes with them. In the last week, 81 percent of the 1249 health care professionals polled reported using a vitamin, trace, or other non-herbal dietary supplements. The factors that resulted in a rise in supplement use were older age, female, high awareness of dietary supplements, and discussing dietary supplements with patients. Conclusion Among HCPs enrolled in an on-line course on dietary supplements, women, older physicians, those with greater experience, and those who consult with patients about dietary supplements had the highest use of dietary supplements. Additional research is required to determine the effect of professionals' personal use of dietary supplements on patient contact.
Source link: https://doi.org/10.1186/1472-6882-6-21
Coltect is a novel dietary supplement that contains curcumin, green tea, and selenomethionine. Using the 1,2-dimethylhydrazine model in rats, the present study investigated the chemopreventive effect of Coltect alone or mixed with 5-aminosalicylic acid. Methods: Coltect's effect on HT-29 CRC cells was determined by growth inhibition assay assay. Male rats were injected with DMH in vivo and treated with Coltect 150 mg/kg, 5-ASA 50 mg/kg, or their combination by oral gavage. Methylene blue staining revealed the crypt foci in Aberrant. Coltect-dependent HT-29 cells had a dose-dependent response to Coltect. The induction of mild-moderate apoptosis in cancer cells in comparison to untreated cells can be attributed to part of the growth inhibition. The Coltect factory reduced the number of small and large ACF to 5-ASA — according to 5-ASA. Conclusion: Coltect slows the proliferation of colon cancer cells, promotes apoptosis, and reduces ACF formation.
Source link: https://doi.org/10.1177/1756283X10379258
To collect objective data on pain tolerance and interference with daily life, subjective pain and daily living questionnaires were used. Results: After 8 weeks, a dramatic decrease of chronic pain was seen both at rest and in vigorous physical activity. After two weeks, plasma fibrinogen, von Willebrand Factor, and serum matrix metalloproteinase-9 showed decrease after 2 weeks, while a decrease in serum interleukin-1 receptor antagonists was statistically significant after 2 weeks. Following pain relief and changes to MMP-9 after eight weeks was highly noticeable, but the association of pain reduction and changes to IL-1ra remained crucial at two weeks after the group's consumption of 3 caps once daily was highly significant.
In propolis collected in Opole area, the aim of the research was to determine the presence of selected harmful elements bioaccumulation. Propolis can be used as a nutritional supplement, according to the present report. Samples of propolis obtained from 3 bee colonies in 30 apiaries were used in the study. The order of accumulation of study components in propolis was as follows: Zn > Cu > Pb > Pb> As > Cd. Only the copper average content in propolis met acceptable guidelines, only the copper average content, while other elements' mean contents greatly exceed these guidelines.
Source link: https://doi.org/10.5219/184
Abstract Background Epilepsy is the most common medical disorder in dogs. In some dogs with IE, an MCT-enriched diet has been shown to improve seizure control and behavioral comorbidities in those dogs with IE. Any dogs are injected with either the control oil or MCT oil alongside their normal diet are first fed for 90 days and two days with the other supplement, which also includes a 7-day washout period. If the study findings confirms the earlier findings, this will add to the credibility of MCTs as a treatment option for canine epilepsy.
Source link: https://doi.org/10.1186/s12917-019-1915-8
Using specific marker reactions in human liver microsomes or recombinant supersomes, we investigated the inhibitory activity of these xanthophylls in vitro on seven major human hepatic UGTs in vitro by LC-MS/MS using specific marker reactions. And, via UGT1A1 inhibition, we also predicted future dietary supplement-drug interactions for -cryptoxanthin. The seven UGTs showed no apparent inhibition astaxanthin and zeaxanthin, according to us, although the remaining xanthophylls showed only weak inhibitory results. Canthaxanthin barely impeded UGT1A1 and UGT1A3 with IC50 values of 38. 7 3. 79 M, respectively; and lutein inhibited UGT1A1 and UGT1A3, with IC50 values of 38. 5 4. 65 and 41. 2 3. 14 3. 14 M, respectively; and with IC50 values of 48. 5 3. 79 M; respectively; and UGT1A3A4A1A1A1A1A1A1A1A3A3A3A1A3A1A1 4. 61 and 42. 8 M and 48. 5 M; and UGT1A4A3; and UGT1A3M; and UGT1A3; and 48. 5 3. 14; and 41. 2 M; and 41. 2 M; and 41. 2 M; and 41. 2 M; and 38. 5 M; and 41. 2 M; and UGT1M; and 41. 2 M; and 41. 2 Among the tested xanthophyll-UGT pairs, cryptoxanthin had the most competitive inhibition of UGT1A1 in a competitive test. In addition, we estimated the possibility of UGT1A1 inhibition in vivo using the highest plasma concentration after oral administration of -cryptoxanthin in humans.
Source link: https://doi.org/10.3390/molecules21081052
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