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Dietary Fiber - ClinicalTrials.gov

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Last Updated: 23 September 2022

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Impact of a High-Soluble Fiber Diet on the Gut-Muscle Axis in Older Adults

During aging, muscle mass, and physical fitness, decrease, but lipids and adipocyte levels increase within and between muscle cells, thus increasing muscle composition and muscle mass. According to our report, an improved quality of life and healthy aging in older adults will necessitate muscle mass, muscle composition, and physical appearance. The gut microbiome and its metabolic products are involved in mechanisms that influence bone mass, muscle composition, and physical function, which have been referred to as the gut-muscle axis. Both phenol sulfate and phenylacetylglutamine were gut microbiome-derived metabolites that were associated with poor muscle composition and poor physical function in studies of older adult humans that were published by our team. These findings, taken together, reveal that initiatives aimed at raising bacterial SCFA production may be a crucial step toward improving muscle-related screening in older adults. Soluble fiber fermentation by gut bacteria results in the production of acetate, propionate, and butyrate, as well as fecal SCFAs proportionally increasing, although circulating levels of IS and PCS have been reduced in response to high-soluble fiber diets. These results show that a high-soluble fiber diet may be a novel option for improving muscle-related fitness in older adults humans. When considering that fecal levels of SCFAs decrease during aging, and that plasma levels of IS, PCS, PS, and PAG increase, these results show that a high-soluble fiber diet may be a helpful strategy for improving muscle-related measures in older adults humans.

Source link: https://clinicaltrials.gov/ct2/show/NCT05549622


WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study

Participants will be taking inulin or maltodextrin for three weeks before the introduction of the Ty21a typhoid fever vaccine, 1 week before the vaccine, and 1 week after the vaccine. Vaccine responses will be measured by counting T cells and immunoglobulin G or immunoglobulin A-secretive plasma cells specific for Ty21a. By testing blood for markers of inflammation, systemic inflammation and immune activation will be determined.

Source link: https://clinicaltrials.gov/ct2/show/NCT04543877


Influences of High-fiber, Organic Whole-food Formula on the Gut Microbiome in Critically Ill Children

In critically ill children, the gastrointestinal microbiome has been shown to have been modified, such that pathogenic bacteria has risen significantly. Pediasure or Nourish will randomly select critically ill children who are well enough for enteral tube feedings to be selected either Pediasure or Nourish. This report will look at the microbiome before and after the introduction of enteral tube feedings to see if either method is associated with a change in the microbiome toward a favorable profile.

Source link: https://clinicaltrials.gov/ct2/show/NCT03414775


Diagnostic Accuracy of Electrochemical Skin Conductance Measurement in Paediatric Small Fibre Neuropathy Following Neurotoxic Chemotherapy

Pediatric chemotherapy-induced neuropathy is an early, often fatal, and dose limiting adverse effect of chemotherapy treatment in immuno-hematology and cancer. Platinum compounds are used for the treatment of various solid tumors. In 37-50% and 3-8% of patients for Common Terminology Criteria for Adverse Effects grade 1/2 and grade 3/4 respectively, Oxaliplatin peripheral neurotoxicity is seen in 37-50% and 3-8% of patients. In a very recent report, 23,5% of patients suffered with a decrease in sural sensory nerve amplitude several years after exposure to neurotoxic chemotherapy, indicating a long-term effects with an irreversible reduction of functioning axons. The key factors contributing to the occurrence of vincristine-induced CIPN may include the effects of vincristine's tubulin polymerization resulting in microtubule destabilization and a lack in axonal transport. -Diagnosis and treatment of pediatric chemotherapy-induced neuropathy in the peripheral nerve system are often under-recognized and undiagnosed. The Total Neuropathy Scale was developed as a clinical investigation of peripheral neuropathy in adults and has demonstrated reversibility and validity in measuring CIPN in adult cancer patients in recent years. The pediatric modified Total Neuropathy Scale has been created and tested in a population of children with cancer with acceptable interrater stability, test retest reliability, and internal consistency. Skin biopsy is the most commonly used test for determining small fiber neuropathy. SUDOSCAN'su00ae Among the tiny fibers that line the sweat glands degenerate after hazardous injury and are the first to recover if the harmful injury is removed, with the first to recover if the harmful injury is removed. Hence, the fibers that innervate the sweat glands could be a good indicator of small fibers injuries. The device automatically calculates ESC, expressed in microSiemens, as the ratio between the current generation and the electrodes' constant direct current stimulation. ESC is thought to represent the innervation of cutaneous sweat glands that contain functional chloride channels. In comparison to the gold standard IENFD, this method has been compared to reference methods for determining small fiber dysfunction and diagnostic results. In addition, the diagnostic accuracy for detecting small-fiber neuropathies of ESC measurements was found in 87 adult patients with clinically defined or potential small-fiber neuropathy. Thus, the combination of PEL, assessing sensory A-delta fibers of WDT in adulthood, and ESCs, evaluating autonomous C fibers, appears to be a valid diagnosis for SFN. According to all groups of age and values seen in healthy adults, values for ESC measurements in healthy children are similar, implying that sudomotor nerve maturation occurs early in life. Thus, ESC testing may be a quick, reproductible, non-invasive, and quantitative assessment of small fiber abnormalities in children.

Source link: https://clinicaltrials.gov/ct2/show/NCT04262778


Intravenous Immunoglobulin (IVIG) in the Treatment of Small Fiber Neuropathy Due to TS-HDS, FGFR-3, or Plexin-D1 Antibodies: a Double Blinded Placebo-controlled Phase II Trial

Small fiber neuropathy is a more common disease in neurology and neuromuscular centers. Many patients with undiagnosed pain syndromes, including fibromyalgia, are finding SFN using modern diagnostic techniques, such as skin biopsy and autonomic nervous testing. In large numbers in SFN patients, there is mounting evidence that Intravenous Immunoglobulin can cause pain relief and raise objective nerve fiber densities on skin biopsies.

Source link: https://clinicaltrials.gov/ct2/show/NCT04153422

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions