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Diagnostic Performance - Europe PMC

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Last Updated: 04 August 2022

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Deep learning for prediction of isocitrate dehydrogenase mutation in gliomas: a critical approach, systematic review and meta-analysis of the diagnostic test performance using a Bayesian approach.

The characterization of isocitrate dehydrogenase mutation in gliomas is based on histopathological examination of tissue specimens obtained by stereotactic biopsy or definitive resection. Accurate pre-treatment determination of IDH mutation status using magnetic resonance imaging can aid in clinical decision-making. In gliomas, we intend to investigate deep learning's diagnostic results in order to determine IDH mutation status. The raw receiver operating characteristic curve was 93. 9%, 90. 9%, and 0. 958, respectively. According to a negative test for preparation sets and validation sets, the Bayes theorem delivered a test likelihood of 97. 6% and 96. 6%, respectively, with a reported pretest probability of 82 percent and 96. 0%. This is the first meta-analysis that summarizes the diagnostic results of DL in predicting IDH mutation status in gliomas via the Bayes theorem. The DL algorithms' excellent diagnostic results in predicting IDH mutation in gliomas suggest an excellent diagnostic success.

Source link: https://europepmc.org/article/MED/35919062


Deep learning for prediction of isocitrate dehydrogenase mutation in gliomas: a critical approach, systematic review and meta-analysis of the diagnostic test performance using a Bayesian approach

We want to determine IDH mutation status in gliomas by looking deep learning's diagnostic results. Patients with histopathologically confirmed World Health Organization grade II, III, or IV gliomas; histopathologic testing with the IDH mutation; and original research papers; and patients with conflict matrices; patients with the IDH mutation status; patients with histopathologically confirmed World Health Organization grade II, III, or IV gliomas; and original research papers. The Bayes theorem gave a positive test success of 97. 6% and 96. 0% respectively for a negative test for training sets and validation sets, with a reported pretest probability of 82 percent and 96. 6% for a negative test of training sets and validation sets. Discussion in the Bayes Theorem is the first meta-analysis that summarizes the diagnostic results of DL in predicting IDH mutation status in gliomas.

Source link: https://europepmc.org/article/MED/PMC9338374


Diagnostic performance of metagenomic next-generation sequencing in non-tuberculous mycobacterial pulmonary disease when applied to clinical practice.

960, a non-tuberculous mycobacterial disease diagnosis by metagenomic next-generation sequencing with Bactec mycobacterial growth indicator tube 960. Methods A total of 422 patients with suspected NTMPD in Shanghai Pulmonary Hospital between January 2020 and May 2021 were retrospectively assessed, including 194 who were not diagnosed with NTMPD; 194 were diagnosed with NTMPD. For NTMPD, the diagnostic results of mNGS and MGIT 960 were evaluated. Results The sensitivity of mNGS in NTMPD diagnosis was 84% and higher than that of MGIT 960. In NTMPD diagnosis, the sensitivity of combined mNGS and MGIT 960 was 91. 8%.

Source link: https://europepmc.org/article/MED/35913608


Localization-adjusted diagnostic performance and assistance effect of a computer-aided detection system for pneumothorax and consolidation.

Although many deep-learning-based computer-aided detection algorithms for abnormality detection in chest radiographs have been developed and commercialized, their ability to localize a target abnormality is rarely reported. We investigated localization reliability, localization-adjusted discrimination, and calibration of a commercially available deep-learning-based CAD for detecting consolidation and pneumothorax in a multi-center, stand-alone clinical trial using temporal and external validation datasets of 1,050 CXRs. The CAD produced image-level AUROC of 0. 960, with sensitivity of 0. 943, tolerance of 0. 901, modification for consolidation, and image-level AUROC of 0. 996, moderate calibration for pneumothorax. The CAD assistance on clinicians' diagnostic results was estimated in a separate trial for diagnostic use using 461 CXRs.

Source link: https://europepmc.org/article/MED/35908091


Evaluating the effectiveness of abbreviated breast MRI (abMRI) interpretation training for mammogram readers: a multi-centre study assessing diagnostic performance, using an enriched dataset.

Background Abbreviated breast MRI is being used in breast screening studies and clinical practice, especially for women with dense breasts. Upscaling of abMRI services requires the mammogram readers to know how to interpret abMRI properly. This research was intended to investigate the diagnostic capabilities of mammogram readers to interpret abMRI after a single day of standardised small-group training and to compare the results of mammogram readers with those with no fpMRI interpretation experience. Six NHS Breast Screening Programme participants were recruited from six NHS Breast Screening Programme sites, according to Methods Mammogram readers. Conclusions An overall diagnostic outcome in mammogram readers new to breast MRI was good enough for diagnostic accuracy of mammogram readers new to breast MRI to match that of experienced fpMRI readers, according to a single-day abMRI interpretation course for mammogram readers.

Source link: https://europepmc.org/article/MED/35907862


Diagnostic performance of metagenomic next-generation sequencing for the detection of pathogens in bronchoalveolar lavage fluid in patients with pulmonary infections: Systematic review and meta-analysis.

Background The finding of pathogens in patients with pulmonary disease has long been a major challenge in medicine. bronchoalveolar lavage fluid will better reflect the true condition of the lungs than sputum and throat swabs. Patients with pulmonary infections that were severely ill or immunocompromised strongly affected heterogeneity, according to subgroup analysis of mNGS' sensitivity showed that patients with pulmonary infections that were persistently ill or immunocompromised had a significant role in heterogeneity. 92 percent positive detection rate of pathogens in BALF of critically or immunocompromised pulmonary-infected patients had a 92% sensitivity. Conclusion mNGS has excellent diagnostic results for BALF pathogens in patients with pulmonary pneumonia, particularly in critically ill or immunocompromised patients.

Source link: https://europepmc.org/article/MED/35907477


The Diagnostic Performance of Multi-Detector Computed Tomography (MDCT) in Depiction of Acute Spondylodiscitis in an Emergency Department.

Background The diagnosis of acute spondylodiscitis can be difficult because clinical onset signs are highly variable. The aim of our research was to determine MDCT quality and how this diagnostic technique could aid doctors in the case of acute spondylodiscitis in an emergency situation by comparing MDCT results to MRI, which is the gold standard. Methods We searched our radiological archive for all MRI examinations of patients who had been monitored for a suspicion of acute spondylodiscitis during the period from January 2017 to January 2021. Only patients who had undergone MDCT examination prior to MRI examination were included in the study. In 13 of the 25 patients, the presence of acute spondylodiscitis was discovered by MDCT. However, we do recommend doing an elective MRI scan in negative cases, in which pathological findings are impossible to interpret with CT alone.

Source link: https://europepmc.org/article/MED/35894025


Diagnostic performance of S100B as a rule out test for intracranial pathology in head injured patients presenting to the Emergency Department who meet NICE CT-head criteria- A BRAIN Project Study

Patients with NICE CT-head criteria within 6 to 24-hours of injury were screened for S100B, according to the NICE CT-head criteria. Methods: Adult patients with mild TBI who were able to give their own informed consent and were subjected to a CT-head scan as part of routine care were included in this multi-centre prospective observational study. Serum was tested for S100B using a Cobas Elecsys S100 module; the validated threshold indicates a positive result. S100B as a rule out measure would have reduced CT scans by 37. 4% within 24 hours and 27. 1% within 6-hours, according to theoretically. S100B's findings Within 6-hours of injury, it was a surgical test to rule out significant intracranial pathology in patients with mild head injuries, limiting the risk of missed injury. Patients could be discharged sooner from ED if used in lieu of NICE CT-head guidelines, in theory. S100B has proven promise diagnostically as an objective marker that can rule out intracranial injuries in head injured patients. The S100B has a tested platform that could be used to reduce CT head demand in EDs. This research findings shows that S100B may theoretically reduce CT-head demand and enable early ED discharge in low-risk patients meeting NICE CT-head guidelines. This low-risk population has a poor yield of traumatic CT abnormalities and could be a good population to target biomarker use.

Source link: https://europepmc.org/article/PPR/PPR523994


Urogenital schistosomiasis prevalence and diagnostic performance of urine filtration and urinalysis reagent strip in schoolchildren, Ethiopia.

Urogenital schistosomiasis has been reported to be endemic in several Ethiopian lowland areas. This research sought to determine the prevalence of urogenital schistosomiasis in schoolchildren and to evaluate urine filtration and urinalysis reagent strip in Amibara, Kurmuk and Abobo districts, Ethiopia, thus faring. Using a urine filtration system and a urine reagent strip was obtained and examined by each study participant. Using Kappa results, an agreement between urine filtration method and urnalysis reagent strip was established. S. haematobium egg positives were among the 1,171 urine samples from schoolchildren examined by a urine filtration technique, with 143 of them being S. haematobium egg positive. 264 of the total 1,171 urine samples tested by dipstick were positive for haematuria. In Abobo, the prevalence of urogenital schistosomiasis was greater than in Hassoba and Kurmuk, according to both urine filtration and urinalysis reagent strip methods. Compared to S. haematobium egg negative children, egg-positive children had a significantly elevated risk of having haematuria. The agreement between urine filtration methods and a urinalysis reagent strip for detecting urogenital schistosomiasis was high. Conclusion In schoolchildren in Abobo, Hassoba, and Kurmuk districts, urogenital schistosomiasis was prevalent in the uriogenital schistosomiasis. Hassoba-bure and Kurmuk fall under low category, but in Abobo, it is almost four times higher than Kurmuk and Hassoba-bure. The sensitivity, specificity, positive, and negative predictive values of urinalysis reagent strip were all higher, suggesting that they may have been used as an alternative to mass screening of urogenital schistosomiasis for monitoring and monitoring schistosomiasis intervention projects.

Source link: https://europepmc.org/article/MED/35877771


Diagnostic Performance of IgE Anti-Der p 10 to Identify Patients with Shrimp Allergy.

Background Patients with allergic rhinitis in conjunction with house dust mites have an elevated risk of shrimp allergy. Der p 10 is a candidate biomarker that helps identify the risk of shrimp allergy in allergic rhinitis patients. IgE positive patients against Der p 10. Results All shrimp oral challenge test -positive patients were positive for IgE against Der p 10. Conclusion: Anti-Der p 10 IgE > 1. 2 kUA/mL had the best diagnostic results, with improved diagnostic accuracy predicting shrimp allergy diagnosis, and it could reduce the need for an OCT.

Source link: https://europepmc.org/article/MED/35871518

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions