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Diabetic Macular Edema - Astrophysics Data System

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Last Updated: 02 February 2022

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Vitrectomized versus non-vitrectomized eyes in diabetic macular edema response to ranibizumab—retinal layers thickness as prognostic biomarkers

With ranibizumab intravitreal injections in a pro re nata regimen, the vitreous helps in the prevention of diabetic macular edema. 50 consecutive eyes with diabetic macular edema treated with ranibizumab and 12 months of follow-up have been a result of a prospective study. The final visual acuity of in vitromized eyes was even worse when baseline retinal nerve fiber layers in the central foveal subfield were thicker, indicating a strong correlation. A decrease in retinal nerve fiber layers inner ring thickness was correlated with improved final visual acuity, but only in vitrectomized eyes.

Source link: https://ui.adsabs.harvard.edu/abs/2021NatSR..1123055P/abstract


Analysis of cytokines in the aqueous humor during intravitreal Ranibizumab treatment of diabetic macular edema

This research was designed to investigate the presence of VEGF, b-FGF, TNF, interleukin-1, IL-8, IL-10, and IL-12 in the aqueous humor of diabetic macular edema patients with and without peripheral retinal ischemia during and after treatment with ranibizumab. Patients with diabetic macular edema without peripheral ischemia were excluded from Group 1 of diabetic macular edema. Patients with diabetic macular edema with peripheral ischemia were included in Group 2 of diabetic macular edema with peripheral ischemia. Patients in Groups 1 and 2 of the At an age of about 30 days, patients in Groups 1 and 2 received three intravitreal injections of 2 mg/0. 05 ml ranibizumab during an interval of about 30 days. At the end of therapy, Interleukin 8 levels were significantly different from those in Groups 1 and 2. Both groups showed a significant rise in the median level of interleukin 6 in the group without ischemia and a significant decline in VEGF.

Source link: https://ui.adsabs.harvard.edu/abs/2021NatSR..1123981D/abstract


Differentiating features of OCT angiography in diabetic macular edema

With and without diabetic macular edema, the aim of this review was to compare different optical coherence tomography angiography data in eyes with diabetic retinopathy with and without diabetic macular edema. In deep capillary plexus, the presence of DME was positively associated with geometric perfusion deficit in superficial capillary plexus, capillary non-perfusion of SCP, and GPD in multivariate analysis. In conclusion, the presence of DME in eyes with diabetic retinopathy was associated with more extensive capillary non-perfusion than those without macular edema.

Source link: https://ui.adsabs.harvard.edu/abs/2021NatSR..1123398M/abstract


Infrared reflectance image-guided laser photocoagulation of telangiectatic capillaries in persistent diabetic macular edema

This investigation was intended to determine the detection rate of telangiectatic capillaries with infrared reflectance and optical coherence tomography images, as well as assess the clinical efficacy of IR image-guided focal laser photocoagulation of TelCaps in persistent diabetic macular edema. Corticosteroids, an intravitreal endothelial growth factor, was found in 28 eyes of 28 patients with TelCap and persistent DME refractory to intravitreal endothelial growth factor or corticosteroids. This retrospective case series included 28 eyes of 28 patients with TelCap and persistent DME refractory to intravitreal anti-vascular endothelial growth factor or corticosteroids. Following direct focal laser photocoagulation of the TelCaps, all patients were monitored for more than 12 months. The TelCap closure rate was 51% at 3 months and 74% at 12 months after focal laser photocoagulation. At three and 12 months after focal laser photocoagulation, a notable improvement in visual acuity and reduction in central subfield thickness were observed. In persistent DME, we found that IR imaging and OCT-guided focal laser photocoagulation of TelCaps can yield improved functional and anatomical results.

Source link: https://ui.adsabs.harvard.edu/abs/2021NatSR..1121769R/abstract


Visual/anatomical outcome of diabetic macular edema patients lost to follow-up for more than 1 year

During intravitreal anti-VEGF therapy, researchers began to investigate the cognitive/anatomical results of diabetic macular edema patients who did not recover for more than a year. A retrospective analysis of 182 treatment-nave DME patients was conducted. Among them, we discovered patients LTFU for more than a year after anti-VEGF therapy. On the first visit, last visit before being LTFU, return visit, and post-re-treatment, the results were evaluated and compared to those of DME patients with regular follow-up. During anti-VEGF therapy, Sixty patients with DME were LTFU for more than a year. The ratio of male, diabetes mellitus duration less than 5 years, and poor early anatomic response were both higher than the control group. About three percent of DME patients were LTFU for more than a year, according to the author.

Source link: https://ui.adsabs.harvard.edu/abs/2021NatSR..1118353K/abstract


Aqueous humor analyses of diabetic macular edema patients with subretinal fluid

Patients with or without subtinal fluid were found by a treatment-nave diabetic macular edema patients. Non-proliferative diabetic retinopathy patients with SRF had higher aqueous levels of IL-6 and IL-8 than NPDR patients without SRF, with improved adherence to diabetic retinopathy stage. In addition, proliferative diabetic retinopathy patients with SRF had elevated VEGF and PlGF in aqueous form, as compared to PDR patients without SRF. The SRF group had a larger number of patients with succinate or patch-shaped hard exudates involving the macula and greater central subfield thickness at baseline, according to Fundus and OCT results. The SRF group demonstrated improved response in terms of CST after six months of anti-VEGF therapy, but visual acuity was not correlated with responsiveness. Compared to those with SRF patients with better anatomical response to anti-VEGF therapy, SRF-treated DME patients with SRF had greater anatomical response to anti-VEGF therapy, but no real difference was found on short-term results, but not enough to those without SRF-treated DME patients with SRF.

Source link: https://ui.adsabs.harvard.edu/abs/2021NatSR..1120985K/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions