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Diabetic Foot - Wiley Online Library

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Last Updated: 28 August 2022

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A single arm prospective feasibility study evaluating wound closure with a unique wearable device that provides intermittent plantar compression and offloading in the treatment of non‐healing diabetic foot ulcers

Diabetes foot ulcer prevalence and economic burden continues to rise around the world. Patients with non-u2010healing diabetic foot ulcers UTgrade 1A/Wagner grade 1 were treated every week for up to 12 weeks. Using the visual analogue pain scale, the primary endpoint was complete wound closure at 12 weeks, and secondary endpoints included healing time, percent area reduction, and pain changes. Eight out of ten wounds healed within 12 weeks, with the average healing time being 41 days. 4. 5 as compared to 3. 3 at the end of the study. This innovative intermediate plantar compression and offloading unit can be used as a non-u201healing diabetic foot ulcer therapy alternative. Wound healing was greatly enhanced during surgery, and pain relief was increased.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/iwj.13932


Relationship between items of DMIST and healing of diabetic foot ulcers

A foot ulcer monitoring system was developed for the wound healing process. Although DMIST is useful in determining wound-u2010healing processes, the monitoring of wound healing remains unclear, thereby making the selection of the right therapy based on the assessment difficult. We found the connection between the DMIST items and wound healing. This was a secondary review of five previous studies and was done using DMIST based on the diabetic foot ulcer assessment scale score and DFU images. Some DFUs recovered at 4 weeks from baseline, while others did not, according to the measured DFU healing status. The study population included 146 Indonesian patients and 33 Japanese patients. Depth, maceration, and size were all associated with DFU healing at four weeks from baseline [depth: OR = 0. 317] ; or = 0. 63 ]; length: OR = 0. 235 ].

Source link: https://onlinelibrary.wiley.com/doi/10.1111/iwj.13880


Translation and validation of the Persian version of diabetic foot ulcer scaleshort form (DFS‐SF)

Foot ulcer in diabetic patients can often result in significantly reduced quality of life. The DFSu2010SF was translated into Persian, and then its validity and reliability were tested in 262 patients with DFUs. Spearman's correlation between the DFS' and the EQ's 20105D u20105L's dimensions was evaluated using content validity ratio and content validity index, and criterion reliability was assessed using Spearman's correlation between dimensions of the DFSu2010SF and the EQu20105L's criteria, and a score of content validity was assessed using content validity ratio and content validity index, and criterion validity was evaluated, and criteria validity was assessed using content validity u20105L The average variance extracted and composite reliability was determined using exploratory factor analysis and confirmatory factor analysis, and convergencentu2010discriminant validity was investigated by determining the average variance extracted and composite reliability. For all dimensions, CFA confirmed the DFS/u2010SF as a six-u2010dimension structure with good fit indices of u03c72/df = 2. 15 0. 69. Our results confirmed the validity and reliability of the Persian DFSu2010SF, therefore, it can be used to determine QoL in patients with DFSs in clinical and research settings in Iran.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/iwj.13929


Near infrared spectroscopy in peripheral artery disease and the diabetic foot: A systematic review

Nearly infrared spectroscopy is a proposed alternative to noninvasive diabetic foot testing. With the requirement for tools that measure microvascular presence in diabetic foot disease being abundant, a proposed test for diabetic foot disease is a good start. The use of NIRS in patients with peripheral arterial disease has expanded to its role in investigating the pathophysiology of DFD. TheNIRS may be helpful in determining treatment success and preventing patient PAD's from deteriorating.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/dmrr.3571


Relationships among social support, coping style, self‐stigma, and quality of life in patients with diabetic foot ulcer: A multicentre, cross‐sectional study

Patients with diabetic foot ulcer have a significantly lower quality of life. Other behavioural or social factors may be attributed to other aspects of life. The study included 229 diabetic foot ulcer patients. Selfu2010stigma has direct impacts on quality of life, including social care and coping style. To inform diabetic foot ulcer patients, further clinical intervention strategies for lowering self-u201stigma, as well as increasing social care and positive coping skills are required, thus improving their quality of life.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/iwj.13914


Decreased expression of miR‐204‐3p in peripheral blood and wound margin tissue associated with the onset and poor wound healing of diabetic foot ulcers

A quantitative realu20103p expression test was used to determine miR201204u20103p expression levels in peripheral blood and wound margin tissue of patients, as well as investigating the correlation between miRu2010204. u20103p and wound healing. After 8 weeks, the expression of miR00204+u20103p in peripheral blood and wound margin tissues of DFU patients was positively associated with the healing rate of foot ulcers. MiRu201204U20103p can improve the proliferation and migration of HKC cells and reduce the incidence of apoptosis of HKC cells in a high glucose environment by targeted control of zinc finger protein Kruppel like factor 6. MiRu2010204/u20103p decreased in peripheral blood and wound tissue of T2DM patients, which is closely related to the occurrence and poor wound healing of DFU.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/iwj.13890


FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers

Here, we discovered that FOXM1 regulates neutrophil levels, and inhibition of FOXM1 leads to increased ROS leading to NET formation. Also, we found that TREM1 expression was closely related to clinical recovery of DFUs, suggesting that TREM1 may be a useful biomarker or a potential therapeutic target. Our findings support TREM1's clinical relevance and show that the FOXM1 pathway as a novel promoter of NET formation during diabetic wound healing, as well as other novel therapeutic techniques to promote healing in DFUs.

Source link: https://onlinelibrary.wiley.com/doi/10.15252/embr.202154558


Severe diabetic foot infections without systemic inflammatory response syndrome: Prospective validation of a new category

We wanted to establish the prognostic value of subdividing moderate diabetic foot infections into two categories: mild and moderate/severe. When compared to moderate OM, patients with severe OM had a higher incidence of amputations, major amputations, hospitalizations, and the desire for antibiotic therapy, as well as a longer length of antibiotics. After using the score, moderate infections were subclassified into 73 moderate cases and 38 severe/severe cases. No similarities were found between moderate/severe and severe infections with systemic inflammatory response syndrome, which had no differences in prognosis. Moderate/severe diabetic foot infections, which may also be identified as acute infections without systemic inflammatory response syndrome, should be included as a new subgroup. Due to its prognostic value, we suggest combining severe diabetic foot infections with and without systemic inflammatory response syndrome. In addition, OM should be added to both moderate and severe new categories of diabetic foot infections.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/wrr.13038


Evaluation of foot ulcer incidence in diabetic patients at a diabetic foot ulcer prevention clinic over a 10‐year period

Diabetes patients were followed by our outpatient clinic for diabetic foot ulcer prevention and then investigation the prevalence and aetiology of diabetic foot ulcers in a 10-year span, according to the current study. Between the day of the first visit and December 31, 2018, 20 out of 942 patients experiencing the ulcers were analyzed using the patients' medical records. A Cox regression study revealed a history of diabetic foot ulcers and the male sex of diabetic foot ulcer formation to be correlated with diabetic foot ulcer formation. These results may indicate that diabetic foot ulcer patients with a diabetic foot ulcer history must have at least an annual follow-up in order to reduce diabetic foot ulcer incidence, according to the authors, although studies involving control groups should be published as evidence.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/wrr.13039

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions