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Diabetic Foot - Springer Nature

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Last Updated: 28 August 2022

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Holistic multi-class classification & grading of diabetic foot ulcerations from plantar thermal images using deep learning

Purpose: Diabetic foot is a common problem that results in ulceration in the feet caused by diabetes mellitus. Most patients have decreased sensitivity to pain as a result of diabetic neuropathy. Methods We recommend a new convolutional neural network for discrimination between non-DM and five DM severity ratings from plantar thermal images and compare its results against pre-trained networks such as AlexNet and similar sites. Tests and Evaluation Our new model delivered the highest results in combined diabetic foot detection and grading, with mean sensitivity of 0. 9684, mean specificity of 0. 9892, and mean specificity of 0. 9892. This report provides a new state-of-the-art in plantar foot thermogram detection and grading, to the first to implement a holistic multi-class classification and grading system, according to the author. Automatic thermogram grading is the first step toward the introduction of smart health products for DM patients.

Source link: https://doi.org/10.1007/s13755-022-00194-8


Potential of stem cells for treating infected Diabetic Foot Wounds and Ulcers: a systematic review

Infected diabetic foot ulcers are causing major concern, because they generally heal poorly and are pre-disposed to diabetic-related foot ulcers and even death. Stem cell therapy seems to enhance iDFU due to its antimicrobial effects, but concrete evidence regarding the repair of iDFUs with SCT is lacking. SCT can be used to provide consistent evidence about the antimicrobial effects of SCT on diabetic animals and humans. Herein, published articles are reviewed to bring together consistent data about the repair of iDFUs. Six preclinical and five scientific studies on SCT's ability were gathered in the hopes of treating ulcers or ulcers in infected diabetic wounds or ulcers. SCT has been a promising therapy for diabetic wounds and ulcers, according to some of the human studies. Moreover, stem cells alone had lower therapeutic value than when mixed with a biostimulant.

Source link: https://doi.org/10.1007/s11033-022-07721-6


WDR74 facilitates TGF-β/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice

Diabetic foot ulcer is a common contributor to diabetes disease progression, contributing to reduced quality of life and elevated mortality in diabetic patients. Therefore, this research aims to clarify the mechanism involved in wound healing in mouse models of DFU. WDR74 and TGF-u03b2 were used in mouse macrophage models of DFU and primary bone marrow macrophages in mouse models of DFU and primary bone marrow macrophages, respectively, in mice models of DFU and primary bone marrow macrophages, as shown by gain- and loss-of-function experiments. By co-immunoprecipitation, the interaction between WDR74 and Smad2/3 in macrophages was confirmed. In wound tissue from DFU mice, we discovered that WDR74 and M2 macrophages were reduced in wound tissue. The TGF-u03b2/Smad pathway activation increased the expression of M2 macrophage markers, IL-4, while decreased M1 macrophage marker expression decreased. We also noticed that overexpression of WDR74 increased Smad2/3 phosphorylation, increased M2 macrophage and ECM production, and reduced DFU. WDR74 is a research group that supports M2 macrophage polarization and ECM production in the United States. In murine DFU, the WDR74 enhances wound healing.

Source link: https://doi.org/10.1007/s10565-022-09748-8


Effectiveness and safety of stem cell therapy for diabetic foot: a meta-analysis update

Background Diabetic foot is one of the most common and serious complications of diabetes mellitus, and it puts a lot of psychological and economic strain on patients. This research was designed to investigate the effectiveness of stem cells in diabetic foot therapy. Continuous results were presented as standardized mean differences with 95% CIs, according to risk ratios with 95% confidence intervals. Conclusions The meta-analysis of the latest findings has found that stem cells are significantly more effective than traditional methods in the treatment of diabetic foot and can also improve patient quality of life following treatment.

Source link: https://doi.org/10.1186/s13287-022-03110-9


A qualitative study of barriers to care-seeking for diabetic foot ulceration across multiple levels of the healthcare system

Introduction The causes of the observed differences in diabetes-related amputation are poorly understood, and it may be related to diabetic foot ulceration care. This qualitative research sought to discover patients' personal experiences with the healthcare system and the barriers they encountered. Among the 15 participants in the study, the mean age was 52. 4 years, 66. 7% was from minority racial groups, and 73 percent was Medicaid or Indian Health Service beneficiaries. Participants also noted inadequate preventative foot care and education before the DFU's inception, and many respondents reported first misdiagnoses and delays in receiving medical attention. Patients with DFUs face significant challenges in accessing medical services at several levels in the healthcare system and elsewhere. These results highlight the need to investigate diabetic foot disorders and the inequitable burden of inadequately managed diabetic foot care.

Source link: https://doi.org/10.1186/s13047-022-00561-4


Machine learning algorithm to evaluate risk factors of diabetic foot ulcers and its severity

Using machine learning techniques, early detection of the risk factors associated with the development of diabetic foot ulcer can be made much simpler. The observational study included eighty people of type 2 diabetes mellitus with DFU and without DFU. Ensemble learning exceeded individual classifiers in terms of various performance evaluation measures, according to various performance evaluation results. The development of DFU in diabetes mellitus was identified by new risk factors, including ApoA1 and IL-10. According to its severity, IL-10 plus uric acid could differe the grades of ulcers. Both the stages of classification, which can be used as a complement to computational testing for DFU and its subtypes, resulted in improved prediction accuracy for both the stages of classification that can be used as a complementary method for computational screening for DFU and its subtypes using the Stacking C algorithm. Graphical abstract T2DM with DFU/T2DM, without DFU and ulcer type classifications.

Source link: https://doi.org/10.1007/s11517-022-02617-w


Stem and Somatic Cell Monotherapy for the Treatment of Diabetic Foot Ulcers: Review of Clinical Studies and Mechanisms of Action

Diabetic foot ulcer is one of the most common diabetes mellitus disorders, most often resulting in a leg amputation. However, there is no agreement on the most effective cell type for DFU therapy. Different cell types contribute to chronic wound healing by different mechanisms. We reviewed the clinical evidence in which stem and somatic cell-based therapy was used as a monotherapy in the present review. Topical application of somatic cells contributes to DFU healing, only, while injecting mesenchymal stem cells and mononuclear cells can irreversibly damage a pathophysiological chain leading from insufficient blood supply to DFU formation. Cell therapy, unquestionably, is a potent tool for the treatment of DFU. Different methods may be used in chronic wound healing by Stem and somatic cells monotherapy.

Source link: https://doi.org/10.1007/s12015-022-10379-z

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions