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Diabetic Foot - PubMed

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Last Updated: 28 August 2022

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Modified poly(L-lysine)-based structures as novel antimicrobials for diabetic foot infections, an in-vitro study.

Chronic wound infections treatment is difficult due to antibiotic resistance and biofilm production by bacteria including S. aureus and P. aeruginosa, which are two of the most common causative pathogens. Methods: We analyzed antimicrobial and anti-biofilm activity of star-shaped polymers against S. austria and P. aeruginosa strains and clinical isolates recovered from wound wounds of diabetic foot wounds in a Dublin Hospital in 2019. After 1 hour incubation, P. aeruginosa clinical isolates from DFW showed similar killing ability against 20 S. augerus and five P. aeruginosa clinical isolates from DFW, resulting in similar killing potency against 20 S. auroch and five P. aeruginosa clinical isolates, resulting in similar killing potency against 20 S. auburnus and five P. aeruginosa clinical isolates from DFW. Potent anti-biofilm activity was demonstrated against S. aurigourou 25923, but experimental isolates, low to moderate loss of biofilm viability was shown against PLL 160 and G3PLL 10 at 50 °°bcM and 200 u03bcM with high inter-isolate variability.

Source link: https://doi.org/10.12688/hrbopenres.13380.1


Prevalence of foot ulcers in diabetic patients in Punjab, Pakistan.

The primary aim of this research was to determine the prevalence of foot ulcers and their associated diabetic conditions among diabetic patients in Punjab, Pakistan. In the state of Punjab, Pakistan, a multistage cluster random sampling method was used to perform a cross-sectional study. A sample of 1,503 people with diabetes was selected from various groups, including 544 men and 999 women. To determine the causes associated with a diabetic foot ulcer, a binary multiple logistic regression analysis was used. The overall prevalence of diabetic foot ulcers in the United States was 16. 83%. According to the income status, subjects with monthly income above Rs. 400 are not eligible. Foot ulcers in Punjab, Pakistan, were discovered in this study, with a high incidence of foot ulcers. The findings reveal that diabetic foot ulcers have risen to a major health issue among diabetic patients, and that improved strategies and preventive steps can be adopted to cope with the epidemic.

Source link: https://doi.org/10.3389/fpubh.2022.967733


The Outcome of Surgical Treatment for the Neuropathic Diabetic Foot Lesions-A Single-Center Study.

The prevalence of diabetic foot problems is on the rise as diabetes has become one of our time's most common epidemics. ' The primary aim of this report was to describe the appropriate surgical treatment for the complicated neuropathic diabetic foot; the secondary aim was to determine the risk factors involved with minor/major amputation and positive or adverse surgical results. This is an observational, retrospective review that was conducted between 1 January 2018 and December 31, 2019 at the Dr. Cantacuzino Clinical Hospital in Bucharest, with type II diabetes mellitus and neuropathic diabetic foot problems. According to p = 0. 011, OR = 2. 975, 95% CI and p = 0. 001, respectively, admission anemia and diabetic nephropathy were indicative of a major therapeutic intervention. The complicated neuropathic diabetic foot requires surgery that has mainly associated with a positive result.

Source link: https://doi.org/10.3390/life12081156


Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil.

Diabetic foot infections are one of the causes of diabetic hospitalization in diabetic patients, and, when this occurs, empirical antibiotic therapy is required. We've conducted a retrospective review of patients with DFI with DFI that necessitated hospitalization to determine microbiologic profile and the susceptibility pattern of these infections. P. aeruginosa was the most common agent among Gram-negative pathogens. Gram-negatives were very good, with 76% susceptibility from P. aeruginosa to ceftazidime and meropenem. Knowing of the microbiological profile and susceptibility patterns of patients with DFIs is a helpful tool to guide empirical therapy.

Source link: https://doi.org/10.3390/antibiotics11081125


Potential of stem cells for treating infected Diabetic Foot Wounds and Ulcers: a systematic review.

Infected diabetic foot ulcers cause significant anxiety because they generally heal poorly and are preceptive of diabetic-related foot ulceration and even death. Stem cell therapy seems to enhance iDFU by its antimicrobial effects, but dependable data regarding the repair of iDFUs with SCT is lacking. Herein, published papers are reviewed in order to present consistent evidence regarding SCT's antimicrobial effects on diabetic animals and humans. Six preclinical and five research studies pertaining to SCT's ability in healing infected diabetic wounds or ulcers were selected. SCT has been shown to be a promising treatment for diabetic wounds and ulcers in several of the human studies. Moreover, stem cells alone had less therapeutic value than when mixed with a biostimulant.

Source link: https://doi.org/10.1007/s11033-022-07721-6


Development of a self-monitoring tool for diabetic foot prevention using smartphone-based thermography: Plantar thermal pattern changes and usability in the home environment.

Thermography, a well-known risk-assessment device for diabetic foot ulcers, is a well-known risk-assessment device for diabetic foot ulcers, but it is not widely used in the home setting due to the presence of the complex home environment on thermographic images. This research looked at changes in thermographic images in turbulent home environments to determine the use of smartphone-based thermography in home settings. During different times of the day for four days, health volunteers were recruited and expected to photograph plantar thermal images using smartphone-based thermography attached to a selfie stick at various times of the day. The plantar thermal photographs' highest temperature regions were identified and classified. Following awakening compared to other time periods, the medial arch pattern is most apparent. This was the first study to investigate plantar thermal profiles in household settings, and the medial arch pattern was the most common hot spot, which matches previous findings in well-controlled clinical settings.

Source link: https://doi.org/10.5582/ddt.2022.01050


Difficulties in the Treatment of Diabetic Foot and Research Progress of Combination of Traditional Chinese and Western Medicine.

Any disease directly related to peripheral arterial disease and/or sensory neuropathies affecting the diabetic foot is related to diabetes in the legs; it is a long-term complication of diabetes. Foot soft tissue, bone, and joint system are all susceptible to damage caused by peripheral neuropathy and peripheral vascular disease swallowing. In addition, diabetic feet are also vulnerable to infection, which can result in lameness and even amputation. Traditional Chinese medicine has a variety of ways for the care of diabetic foot, which can be divided into internal treatment and external therapy of TCM. According to some studies, modern medicine in combination with herbal therapy can greatly enhance diabetic foot prognosis. This report outlined the obstacles in the current clinical trials comparing Chinese and Western medicine in diabetic foot therapy.

Source link: https://doi.org/10.1155/2022/9449427


Relationship between items of DMIST and healing of diabetic foot ulcers.

The creation of a monitoring device for diabetic foot ulcer wound healing was created. Its seven domains, including depth, maceration, inflammation/infection, size, tissue type of the wound bed, type of wound edge, and tunnelling/undermining. Although DMIST is useful in determining wound-healing processes, wound-healing procedures' outcomes are uncertain, leading to the selection of optimal care based on the assessment. We established the connection between the DMIST items and wound healing. This report was a follow-up to five previous studies and was based on the diabetic foot ulcer assessment scale score and DFU images. Some DFUs recovered at 4 weeks from baseline, but some DFUs did not, according to the investigation DFU healing status. At four weeks from baseline, depth, maceration, and height were all associated with DFU recovery [depth: OR = 0. 303 ; size: OR = 0. 623]; depth: OR = 0. 623 ].

Source link: https://doi.org/10.1111/iwj.13880


WDR74 facilitates TGF-β/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice.

Diabetic foot ulcer is a significant contributor to diabetes onset, contributing to reduced quality of life and increased mortality in diabetic patients. Hence, this research seeks to clarify the mechanism involved in wound healing in mouse models of DFU. Gain- and loss-of-function experiments were conducted to determine the roles that WDR74 and TGF-u03b2 play in mouse models of DFU and primary bone marrow macrophages. Interaction of WDR74 and Smad2/3 in macrophages was established by co-immunoprecipitation. Wound tissue from DFU mice was reduced in WDR74 and M2 macrophages, according to our findings. Also, the TGF-u03b2/Smad pathway activation in diabetic mice increased the production of ECM and promoted wound closure. WDR74 overexpression increased Smad2/3 phosphorylation, boosted the number of M2 macrophage and ECM production, and reduced DFU. WDR74 supports M2 macrophage polarization and ECM production. In murine DFU, the WDR74 promotes wound healing.

Source link: https://doi.org/10.1007/s10565-022-09748-8


Holistic care of patients with diabetic foot ulcers during the COVID-19 era: integration of Henderson's Need Theory.

Unfortunately, a research combining theory with nursing care in diabetic foot ulcer care has not been published. When caring for patients with diabetic foot ulcers, who are also at an elevated risk of serious complications from COVID-19, it's important to take a holistic view of the patient and consider both of their needs and the causes affecting them.

Source link: https://doi.org/10.12968/bjon.2022.31.15.S38

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions