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Diabetic Foot - Europe PMC

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Last Updated: 28 August 2022

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Thoughts and experiences on leg amputation among patients with diabetic foot ulcers.

Background Although leg amputation is common among diabetic foot ulcer patients, diabetic foot ulcer patients, only few studies have investigated leg amputation from the perspective of patients. Aim This research aims to investigate the potential of patients with diabetic foot ulcers relating to leg amputation. Conclusion Even if an amputation is not imminent, having a diabetic foot ulcer can lead to divergent concerns about leg amputation. Professional health care professionals should also be aware of how they communicate about leg amputation.

Source link: https://europepmc.org/article/MED/34963426


Potential of stem cells for treating infected Diabetic Foot Wounds and Ulcers: a systematic review.

Infected diabetic foot ulcers cause a lot of anxiety, since they typically heal poorly and are pre-disposed of diabetic-related foot ulceration and even death. Stem cell therapy appears to have improved iDFU by its antimicrobial activity, but there is no evidence regarding the repair of iDFUs with SCT. SCT's antimicrobial effects on diabetes and human diabetic rats and humans are investigated herein to provide consistent information about the repair of iDFUs in diabetic animals and humans. Ultimately, six preclinical and five clinical studies relating to the use of SCT on healing infected diabetic wounds or ulcers were chosen. SCT has been shown to be a promising therapy for diabetic wounds and ulcers, according to some of the human studies. Moreover, stem cells alone had less therapeutic value when mixed with a biostimulant.

Source link: https://europepmc.org/article/MED/36008608


Development of a self-monitoring tool for diabetic foot prevention using smartphone-based thermography: Plantar thermal pattern changes and usability in the home environment.

Thermography, a well-known risk assessment device for diabetic foot ulcers, is well-known in the home setting, but it is not widely used in the home setting due to the influence of the complicated home environment on thermographic images. This report investigated shifts in thermographic images in turbulent home environments to find the suitability of smartphone-based thermography in home settings. During different times of the day for four days, health volunteers were recruited and required to photograph plantar thermal images using smartphone-based thermography attached to a selfie stick at various times of the day. The plantar thermal images' highest temperature were identified and categorized, in areas with the highest temperature. Compared to other time periods, the medial arch pattern is the most noticeable after awakening. The first attempt to investigate plantar thermal patterns in the home environment was the first to investigate the plantar thermal patterns in the home environment, and the medial arch pattern was the most common hot spot, compared to previous studies in well-controlled clinical settings.

Source link: https://europepmc.org/article/MED/36002308


Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in São Paulo, Brazil.

Diabetic foot infections are one of the causes of diabetic hospitalization in diabetic patients, and when this occurs, empirical antibiotic therapy is required. A retrospective review of patients with DFI who required hospitalization to determine microbioc profile and susceptibility pattern of these infections has been carried out by researchers. The most common pathogen, according to E. faecalis, was S. aureus, and coagulase negative Staphylococci. P. aeruginosa was the most common agent among Gram-negative pathogens, among Gram-negative pathogens. Gram-negatives were remarkably good, with 76% susceptibility from P. aeruginosa to ceftazidime and meropenem.

Source link: https://europepmc.org/article/MED/36009994


Relationship between items of DMIST and healing of diabetic foot ulcers.

Although DMIST is useful for determining wound-healing procedures, wound-healing results, the monitoring of wound healing remain uncertain, causing the selection of the right treatment based on the assessment difficult. We established the connection between the DMIST items and wound healing. This was a secondary review of five previous studies and was based on the diabetic foot ulcer assessment scale score and DFU images. After simultaneously monitoring for potential confounders, multivariate logistic regression was used to calculate odds ratios and 95% confidence intervals. Some DFUs recovered at 4 weeks from baseline, while others did not, and some DFUs did not. The scores of each DMIST domain were among the variables included in the models. 146 Indonesian patients and 33 Japanese patients were included in the study sample. According to our results, appropriate maceration control aids in DFU healing.

Source link: https://europepmc.org/article/MED/35985841


WDR74 facilitates TGF-β/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice.

Diabetic foot ulcer is a significant risk of diabetes progression, contributing to reduced quality of life and increased mortality in diabetic patients. In mouse models of DFU and primary bone marrow macrophages, gain- and loss-of-function experiments were conducted to determine the roles that WDR74 and TGF-u03b2 play in mouse models of DFU and primary bone marrow macrophages. By co-imunoprecipitation, an interaction between WDR74 and Smad2/3 in macrophages was detected. In wound tissue samples from DFU mice, we discovered that WDR74 and M2 macrophages were reduced. The expression of M2 macrophage markers soared, IL-4, while the M1 macrophage marker's decreased was raised. b2/Smad pathway activation elevated the expression of M2 macrophage markers, IL-4, while decreasing expression of the M1 macrophage marker decreased. TGF-u03b2/Smad pathway activation in diabetic mice has also increased the production of ECM and promoted wound closure. We also noticed that WDR74 overexpression increased Smad2/3 phosphorylation, boosted the number of M2 macrophage and ECM production, and reduced DFU. In murine DFU, the WDR74 promotes wound healing.

Source link: https://europepmc.org/article/MED/35982296


In situ hydrogel capturing nitric oxide microbubbles accelerates the healing of diabetic foot.

Diabetic foot ulcer is a devastating complication in diabetes patients, putting a high risk of amputation and economic burden on patients. Nitric oxide has been shown to improve acute or chronic wound healing by modulating inflammation and angiogenesis. The cold P407 solution, which was exposed to the DFU wound, would quickly be converted into a semisolid hydrogel under body temperature and successfully capture NO microbubbles. In addition, the PNO gelling temperature was reduced to 31 u00b0C for the P407 polymer, which was near the skin surface's maximum temperature. The PNO gel had mechanical properties comparable to that of the P 407 hydrogel, according to Rheologic experiments. PNO produced remarkable wound healing in rats with DFU, according to In vivo studies. PNO gel, as a whole, can be a promising source of therapeutic NO gas for DFU treatment.

Source link: https://europepmc.org/article/MED/35973472


Comparison of area measurement methods in the routine assessment of diabetic foot ulcers-A consistency analysis method.

Background Ulcer area is a vital factor in diabetic foot ulcer evaluation, but current techniques lacks for routine measurement. Aim We hypothesized that the Image J-based Computer Analysis tool has a high degree of compatibility with the commonly used Maximum Length and Width as well as Transparent Dressing-based Square Grid methods, and was designed to investigate the consistency and verify the capability of the Image J-based Computer Analysis tool in the routine evaluation of ulcers. Methods Outpatients with diabetic foot ulcers at Sun Yat-sen Memorial Hospital's Department of Endocrinology were enrolled between October 2020 and October 2021, according to outpatient patients with diabetic foot ulcers. The Image J-based Computer Analysis and the other two techniques were found to have high consistency between the Image J-based Computer Analysis and the other two techniques, as shown by the following graphs. Conclusion The Image J-based Computer Analysis tool can be used with other techniques to identify ulcer areas.

Source link: https://europepmc.org/article/MED/35971276


Amputation and mortality frequencies associated with diabetic Charcot foot arthropathy: a meta-analysis.

According to 55% and 74% respectively, five-year mortality and amputation risks following new-onset diabetic ulceration have been reported. This meta-analysis aims to provide a quantitative analysis of amputation and mortality risks in a diabetic patient with a Charcot foot arthropathy. With a pooled sample of 2250 patients with 2272 Charcot feet, a total of 16 studies were included in the quantitative meta-analysis, revealing a total of 16 studies. A 1-year mortality rate of 4% was found in two studies involving 255 patients, yielding a 1-year mortality rate of 4%. Seven studies involving 1706 patients revealed a 5-year mortality rate of 24. 5%. CONCLUSION: Diabetic Charcot arthropathy yielded amputation rate of 15% in 871 foot yields, with 9% amputation risk and 5% minor amputations. However, mortality rates were surprisingly low compared to those relating to diabetes foot ulcers' recognized prevalence in the journal.

Source link: https://europepmc.org/article/MED/36028441


Effectiveness and safety of stem cell therapy for diabetic foot: a meta-analysis update.

BACKGROUND Diabetic foot is one of the most common and severe complications of diabetes mellitus, which puts a lot of psychological and economic strain on patients. This study was conducted to determine the effectiveness of stem cells in diabetic foot therapy. ABI = 8. 20 ], pain-free walking distance [MD = 2. 94 ], and rest pain score [OR = 0. 6 ], and amputation rate was much lower than conventional therapy in terms of ulcer or wound healing rate [OR = 8. 20 ], but overall pain reduction [OR = 0. 8 ] was much lower than normal therapy [OR = 0. 19 ]. Conclusions The meta-analysis of the latest research has found that stem cells are significantly more effective than traditional methods in the treatment of diabetic foot disease and can also improve patient quality of life after treatment.

Source link: https://europepmc.org/article/MED/35964145

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions