Diabetes Type 1 - Springer Nature

Circulating Hematopoietic (HSC) and Very-Small Embryonic like (VSEL) Stem Cells in Newly Diagnosed Childhood Diabetes type 1 – Novel Parameters of Beta Cell Destruction/Regeneration Balance and Possible Prognostic Factors of Future Disease Course

Aims/Hypothesis We wanted to find out how hematopoietic stem cells and very small embryonic-like stem cells mobilization were used to establish their role in persistent beta cell function maintenance and partial remission in children newly diagnosed with type 1 diabetes. With the use of flow cytometry, disease onset in PBMC isolated from whole peripheral blood was determined at disease onset in PBMC isolated from whole peripheral blood. Patients with higher-secretion at disease onset had lower HSC, while for VSEL and VSEL/HSC ratio, higher values were reported. Patients with lower HSC levels had a tendency to reduced partial remission risk in the first 3 to 6 months after diagnosis. These clinical findings point to a potential role for HSC and VSEL in retaining residual beta cell function in type 1 diabetic patients.

Source link: https://doi.org/10.1007/s12015-021-10250-7

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