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Diabetes Type 1 - Europe PMC

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Last Updated: 28 June 2022

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Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice.

In this research, bacterium-like particles made from food-grade lactic acid bacteria were used to provide the insulinoma-associated protein 2's intracellular domain. Based on the stability analysis in vitro, BLPs added to the quality of the delivered IA-2ic. BLPs-IA-2ic oral administration in NOD mice reduced T1DM incidence in NOD mice by 53%. BLPs-IA-2ic oral immunization was demonstrated by an immunological study, which revealed antigen-specific T cell tolerance. The results revealed that the successful induction of immune tolerance was dependent on the immune response and CD4 + FoxP3 + regulatory T cells.

Source link: https://europepmc.org/article/MED/35311607


Circulating C-Peptide Levels in Living Children and Young People and Pancreatic β-Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration.

Type 1 diabetes suffers decreases in type 1 diabetes, but type 1 diabetes patients' low, but detectable quantities. Following type 1 diabetes onset, histological studies show that u03b2-cells can persist. 8 of 8 vs. 7 of 8 years: 7 of 8 years: 7 of 8 - 7 of 8 years (32 of 33 years): 7 of 8 vs. 1-5 years postdiagnosis, with those diagnosed at younger ages experiencing more frequent loss of islets containing insulin-positive u2235934 cells in u03b2-cells. 82 of 33 years: 7 of 8, 7 of 28 ; 7 of 8 years: 7 of 8 years: 7 of 26 of 26 of 27 of 31 of 7 of 8 of 8 of 8 of 13 of 8 of 13 of 8 of 8 5713 vs.

Source link: https://europepmc.org/article/MED/35499624


Identification of Novel Disease-Relevant Genes and Pathways in the Pathogenesis of Type 1 Diabetes: A Potential Defect in Pancreatic Iron Homeostasis.

To identify genes that may play disease pathogenesis, we performed differential gene expression analysis in pancreatic islets of NOD mice in contrast to age-matched congenic NOD. B10 controls. We found that Hamp and hepcidin levels were lower in the pancreas of 12-week-old NOD versus NOD. B10 mice, meaning that iron loss might have occurred in the islets during the onset of destructive'" insulitis in the islets. Interestingly, we found that the severity of NOD disease correlates with dietary iron intake. NOD mice on low-iron diets had a reduced risk of hyperglycemia in those on high-iron diets, with an earlier onset and a higher risk of disease, suggesting that high iron intake and a lack of pancreatic iron homeostasis can contribute to NOD disease. This process may explain the connection between high iron intake and the increased risk of T1D in humans.

Source link: https://europepmc.org/article/MED/35499603


Evaluation of clinical metrics for identifying defective physiologic responses to hypoglycemia in long-standing type 1 diabetes.

Repeated hypoglycemia exposure leads to decreased hypoglycemia and the emergence of dysfunctional counterregulatory responses. Diabetes type 1 diabetes patients with chronic insulin induced hypoglycemia and endogenous glucose production reaction to protect against insulin-induced hypoglycemia have been reported by only pancreas or islet transplantation. The experimental subjects, 39 years old and T1D, were 31 with IAH and 11 with hypoglycemic risk awareness, as well as 12 non-diabetic control subjects, underwent single-blinded hyperinsulinemic clamp studies, including 32 with IAH and 11 with hypoglycemic clamp experiments. A composite threshold of IAH-Clarke-u22654 with ROC curve-derived thresholds for CGM measures of hypoglycemia exposure demonstrated high specificity and predictive value in identifying clamp unawareness. Individuals with missing hypoglycemia symptom recognition who may require further intervention could be screened for IAH as well as an analysis of CGM results.

Source link: https://europepmc.org/article/MED/35758724


Hybrid closed loop therapy with a first-generation system increases confidence and independence in diabetes management in youth with Type 1 diabetes.

Aim Hybrid Closed Loop therapy improves glycaemic control in adolescents with Type 1 diabetes; however, little is known about the users' lived experiences with these devices. The intention of this research was to examine youth with Type 1 diabetes using HCL therapy (and their parents) to gain insight into their daily lives. During a six-month randomised clinical trial, adolescents and young adults aged 12 to 25, as well as their parents, were invited to participate in a semi-structured interview at the end of the study. The HbA1c 64 was a young boy with Type 1 diabetes who was 14. 3 years old at 17. 5 years old, meaning 17. 5 yrs, and a 10 parent interview was conducted. Both youth and parents enjoyed the benefits of this first-generation HCL system in improving glycaemic outcomes and providing flexibility and independence.

Source link: https://europepmc.org/article/MED/35757899


Mouse models of type 1 diabetes and their use in skeletal research.

Purpose of research In this review, we explore the three key mouse models of insulin-deficiency diabetes used to investigate the effects of type 1 diabetes on skeletal outcomes. We then describe the skeletal results and/or skeletal phenotypes that have been delineated using these models. Humans with T1D have decreased bone mineral density and an elevated risk of fragility fractures as a result of fragility fracture. Conclusions of mouse studies have given new insight into the underlying mechanisms that account for the abnormalities of bone observed in human T1D T1D.

Source link: https://europepmc.org/article/MED/35749285


Risky self-management behaviors in adolescents with type 1 diabetes: Measurement validation for the Diabetes-Specific Risk-Taking Inventory (DSRI).

Purpose Among people with type 1 diabetes, adolescents and adults with type 1 diabetes have the most trouble finding optimal treatment satisfaction and glycemic goals. During adolescence, risk-taking habits often rises, and may interfere with T1D care participation. To determine risky T1D self-management habits in adolescents with T1D, we created the Diabetes-Specific Risk-Taking Inventory. Methods We conducted a cross-sectional study of a national sample of 224 adolescents from the T1D Exchange registry in a cross-sectional format. Participants completed the DSRI and measures of engagement, general risk-taking, and executive functioning, as well as reports on the incidence of severe hypoglycemia and diabetic ketoacidosis in the last year. Conclusions Overall, preliminary psychometrics report the DSRI is a reliable and valid way to assess risks that adolescents may face with their T1D care. This innovative self-report questionnaire has the ability to be a quick clinical tool to screen for high-risk behaviors that are not normally assessed in T1D clinical care.

Source link: https://europepmc.org/article/MED/35752878


The impact of socioeconomic deprivation on access to diabetes technology in adults with type 1 diabetes.

We investigate the relationship between socioeconomic status and poverty with diabetes products access to diabetes can affect adults with type 1 diabetes. Methods Retrospective, observational study of adults attending a tertiary center in the United Kingdom, which includes three urban hospitals. The English Indices of Deprivation, 2019, assessed socioeconomic deprivation by the deprivation of income by the deprivation of Socioeconomic deprivation. Results In total, 1,631 adults aged 44 to 758 were included, with 391 using continuous subcutaneous insulin infusion, 312 using real-time continuous glucose monitoring, and 558 using intermittently scanned continuous glucose monitoring. In the least impoverished quintile compared to the most impoverished quintile, the most successful use of diabetes medications was in the least deprived quintile. Almost doubled as much participation in structured education from the most deprived to the most marginalized groups compared to the least deprived groups. Adults with white ethnicity were more likely to use technology than those with black ethnicity. Adults in the most impoverished quintile had less technology use when they were younger.

Source link: https://europepmc.org/article/MED/35751860


Prevalence of disordered eating behaviors in adolescents with type 1 diabetes: Results of multicenter Italian Nationwide study.

Objectivity: To determine the prevalence of disordered eating habits in a large sample of Italian adolescents with type 1 diabetes and to investigate potential socioeconomic, medical, and psychological differences between adolescents with and without DEBs. DEPS-r positive results Output: In this survey, 690 adolescents with type 1 diabetes were tested, with 28. 1% being DEPS-positive. Girls had higher DEPS-r total scores than boys, but no age disparities were found in mean DEPS-r total scores. In both genders, adolescents with debs had significantly higher zBI and HbA1c values and severe emotional and behavioral problems than those without DEBs. Adolescents reporting insulin abuse had elevated HbA1c values, higher DEPS-r mean scores, and more psychological difficulties than those who did not. Conclusions: This nationwide report found that DEBs are common in adolescents with T1D, and those suffering from them have poorer clinical conditions and higher emotional and behavioral challenges.

Source link: https://europepmc.org/article/MED/35751499


Efficacy of a new enzyme-linked immunosorbent assay system for three islet cell autoantibodies in Japanese patients with acute-onset type 1 diabetes.

In Japanese patients with acute-onset type 1 diabetes, a new enzyme-linked immunosorbent assay device for simultaneously detecting three islet cell autoantibodies against glutamic acid decarboxylase, insulinoma-associated antigen-2, and zinc transporter 8 has been tested. To determine the clinical sensitivity of a new enzyme-linked immunosorbent assay device for simultaneously detecting three islet cell autoantibodies against glutamic acid decarboxylase In 99 patients with acute-onset T1D and 100 non-diabetic subjects, we compared the positivity results of 3 Screen ICA ELISA to those of each autoantibody alone in 97 patients with acute-onset T1D and 100 non-diabetic patients. The positivity of 3 Screen ICA ELISA was 71% among all T1D patients, while those of GADA, IA-2A, and ZnT8A were 58%, 28. 8%, and 25. 8%, respectively. The median 3 Screen ICA index was 121. 9 and was associated with titers of every autoantibody, most notable with GADA, and was elevated in TPOAb-positive patients than in TPOAb-negative patients. The 3 Screen ICA ELISA study, according to our results, may be a time-saving diagnostic device for determining islet autoantibodies in acute-onset T1D patients.

Source link: https://europepmc.org/article/MED/35753761

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions