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We discovered a reduced amount of the commensal Streptococcus salivarius in T1DM patients's oral cavity, which is attributed to the apparent competition with the pathobiont Streptococcus mutans. The decrease in S. salivarius in the oral cavity in the gastrointestinal was also associated with the gut's shrinking as well as increased numbers of facultative anaerobes, including Enterobacteria. In addition, we found signs of gut inflammation in T1DM as shown in the expression profiles of the Enterobacteria and the human gut proteome. Conclusions Alterations of the oral microbiome in the context of T1DM have an effect on the microbial communities in the lower gut, particularly through the reduction of Streptococcus salivarius "oral-to-gut" transfer. The observed oral-cavity-driven gut microbiome changes, according to our findings, may have played a role in T1DM's inflammation processes.
Source link: https://www.ncbi.nlm.nih.gov/bioproject/840344
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