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Diabetes And Kidney Disease - Europe PMC

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Last Updated: 15 July 2022

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Development and internal validation of machine learning algorithms for end-stage renal disease risk prediction model of people with type 2 diabetes mellitus and diabetic kidney disease.

The most common cause of end-stage renal disease is Aims Diabetic kidney disease, which is associated with elevated morbidity and mortality in diabetic patients. Early detection and prompt intervention and enhanced prognosis are likely to result in the identification of risk factors involved in the progression of DKD to ESRD. This research was also designed to establish a risk prediction system for ESRD in patients with type 2 diabetes mellitus. Methods Between January 2008 and July 2019, a total of 390 Chinese patients with T2DM and DKD confirmed by percutaneous renal biopsy were registered and followed up for at least one year. The critical clinical and pathological characteristics of ESRD were identified by the four machine learning algorithms, which were used to develop a risk prediction model for ESRD. Conclusion Conclusions from machine learning algorithms can accurately predict the event ESRD in DKD participants. Early detection and prompt intervention is likely to raise the prognosis of DKD to ESRD by early detection and prompt intervention. To develop a risk prediction model of ESRD in patients with T2DM and DKD, machine learning algorithms were used to create a risk prediction model of ESRD in patients with T2DM and DKD. Rather than the care of patients with early-phase T2DM with or without mild kidney damage, the emphasis should be placed on indicators of kidney function, diet, anemia, and proteinuria for participants with T2DM and advanced DKD to defer T2DM and advanced DKD to postpone ESRD, rather than age, sex, and monitoring hypertension and glycemia.

Source link: https://europepmc.org/article/MED/35373711


Interactive effects of intrinsic capacity and obesity on the risk of chronic kidney disease in older patients with type 2 diabetes mellitus

There have been no studies on the effects of IC on the risk of chronic kidney disease in older type 2 diabetes mellitus patients. A total of 2482 older patients with T2DM treated by a disease care center were enrolled. According to the KDIGO 2012 CKD definition, the risk of CKD was classified. To determine the relationship between IC score and CKD risk, univariate and multivariate analyses were used. The odds ratio of having a moderately elevated and very high risk stage of CKD was 1. 76 times higher in multivariate analysis, relative to those with an IC score of 2-5. Also, there was a synergistic association between IC score and obesity on the risk of CKD, and the percentage of CKD caused by this interaction was 26%.

Source link: https://europepmc.org/article/PPR/PPR518721


Association of serum total bilirubin levels with progressive renal decline and end-stage kidney disease: 10-year observational cohort study in Japanese patients with diabetes.

Objection Prior studies have shown that serum bilirubin levels could be correlated with diabetic nephropathy progression. Objectives of this investigation are to determine the relationship between basal bilirubin levels and progressive renal disease and end-stage kidney disease. Methods The study of Methods A total of 298 patients with diabetes who visited Kyushu University Hospital were recruited and followed up for ten years. A logistic regression analysis was used to determine the correlation of total bilirubin levels with PRD, and its cut-off point was determined by receiver operating characteristic analysis. The percentage of patients with two endpoints, composite endpoint or 30% eGFR decline, according to the low bilirubin group was much higher in the low bilirubin group than in the high bilirubin group. Conclusions: Serum total bilirubin levels were negatively associated with PRD in diabetic nephropathy, according to the study, and the cut-off point was 0. 5 mg/dL.

Source link: https://europepmc.org/article/MED/35819962


Diet therapy along with Nutrition Education can Improve Renal Function in People with Stages 3-4 chronic kidney disease who do not have diabetes. (A randomized controlled trial).

The effects of renal diet therapy and nutritional education on the estimated Glomerular Filtration Rate, blood pressure, and depression among patients with CKD are investigated. A total of 120 CKD patients were randomly divided into an intensive nutrition intervention group and a control group for 24 weeks. Compared to the control group, the eGFR soared in the intervention group. In addition, serum Cr and the systolic and diastolic blood pressures decreased significantly in the intervention group relative to the control group. The increase in the BUN level and the depression score was also hampered by the diet intervention, which also stifled the rise in the BUN level and the depression score. In addition, the decrease in protein and sodium intake in the intervention group was larger. A significant difference in the mean eGFR between the two groups was also shown at the end of the study by using covariance analysis.

Source link: https://europepmc.org/article/MED/35795914


LASSO-derived nomogram predicting new-onset diabetes mellitus in patients with kidney disease receiving immunosuppressive drugs.

What is known and objective Patients with kidney disease who are receiving immunosuppressive drugs are at a high risk of developing new-onset diabetes mellitus. We wanted to develop a reliable and simple way to detect NODM in patients receiving immunosuppressive drugs. Methods This retrospective review identified 1883 patients who received ISDs between January 2010 and October 2018. In both cohorts using the Hosmer-Lemeshow test and calibration curves, the nomogram's discrimination and calibration capabilities were determined. Among the 1883 patients with kidney disease receiving immunosuppressive medications, 375 and 169 patients developed NODM in the preparation and validation cohorts, respectively. What is new and conclude Nearly one-third of patients with kidney disease receiving immunosuppressive drugs had NODM. Patients with kidney disease receiving immunosuppressive medications may have a higher risk of NODM in patients with NODM in patients with kidney disease receiving immunosuppressive drugs. The nomogram developed in this study may help predict the incidence of NODM in patients with kidney disease.

Source link: https://europepmc.org/article/MED/35791031


Increased neutrophil count Is associated with the development of chronic kidney disease in patients with diabetes.

Background This research seeks to explore the possibility of peripheral inflammatory blood cell markers influencing the occurrence and progression of chronic kidney disease in diabetic patients. The cohort consisted of 2060 people with diabetes derived from two other centers followed up for four years. Conclusions And after 1:1 case-control comparisons for age, gender, recent history of elevated blood pressure, and duration of diabetes, in the cross-sectional study, neutrophil count was the highest risk factor for CKD as an independent risk factor for CKD. After fully accounting for potential confounders, Cox regression analysis results showed that only neutrophil count was positively related to CKD progression. With increasing neutrophil count, the cumulative risk of CKD progression in diabetics with diabetes gradually increased. Conclusions of this research show that neutrophil count is a key risk factor for CKD in diabetic patients.

Source link: https://europepmc.org/article/MED/35789114


Reduction of proteinuria in patients with diabetes kidney disease and dysautonomia through measures aimed at controlling supine hypertension.

This report is based on a series of cases in which nine consecutive patients with DKD, dysautonomia, and supine hypertension were encouraged to use chronotherapy and inclination of the head of the bed in six degrees during sleep. Proteinuria levels in the intervention group decreased significantly, while in the control group, there was an increase in proteinuria. Patients in the intervention group had a substantial decrease in proteinuria, with a change from nephrotic to non-nephrotic proteinuria in the majority of these patients.

Source link: https://europepmc.org/article/MED/35786235


Finerenone: a mineralocorticoid receptor antagonist for the treatment of chronic kidney disease associated with type 2 diabetes.

Introduction Approximately 40% of people with type 2 diabetes have chronic kidney disease, which greatly raises the risk of cardiovascular dysfunction and mortality in people with diabetes. In phase III trials involving over 13,000 patients with diabetic kidney disease, Finerenone has been associated with significant decreases in kidney- and CV-related endpoints compared to placebo and minimal effects on serum potassium and kidney function. Expert opinion Unlike spironolactone and eplerenone, finerenone has a positive benefit-risk profile and is a safe new treatment for patients with CKD and T2D that are T2D.

Source link: https://europepmc.org/article/MED/35762406


Accuracy evaluation of 2021 Chronic Kidney Disease Epidemiology Collaboration, Full Age Spectrum and European Kidney Function Consortium equations for estimating glomerular filtration rate in type 2 diabetes mellitus and healthy adults.

Hypothesis and goals Estimated glomerular filter rate equations' accuracy in diabetes mellitus is controversial. In healthy and type 2 DM participants, we wanted to know the results of three equations: European Kidney Function Consortium, Full Age Spectrum, and 2021 Chronic Kidney Disease Epidemiology Collaboration. With 2021 CKD-EPI and EKFC presenting greater P30 than FAS in the 122 patients with type 2 DM, the equations displayed larger biases, poorer agreement with mGFR, and poor accuracy, with the latter more consistent with mGFR and inferior accuracy. However, all equations fail in people with type 2 DM.

Source link: https://europepmc.org/article/MED/35792160


Making an impact on kidney disease in people with type 2 diabetes: the importance of screening for albuminuria.

In a new strategy, this paper explores albuminuria as a marker of kidney disease and cardiorenal risk, emphasizes the importance of early screening and routine testing for albuminuria in people with T2D, and provides new information on the optimal management of CKD in T2D using albuminuria as a target in a proposed scheme. Elevated urine albumin can be used to detect CKD in people with T2D and monitor its progression; however, there are pitfalls that prevent early detection, such as a lack of CKD in the general population, poor compliance to medical guidelines, and country-level variations in screening and treatment incentives. With albuminuria being used as an entry criterion and a surrogate endpoint in clinical trials, and with new medical technologies available to reduce CKD progression, there is urgent need for early screening and diagnosis of kidney disease in people with T2D or pre-diabetes.

Source link: https://europepmc.org/article/MED/35790319

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions