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Background Although there is abundant evidence that COVID-19 mortality risk among people with intellectual and developmental disabilities is on rise, it is not clear whether this elevated risk resulted in an increased incidence of COVID-19 mortality in the United States or whether comorbidity patterns among COVID-19 deaths are similar or distinct for people with IDD. During the first year of the pandemic, the aim was to determine the differences in COVID-19 mortality burden among decedents with and without IDD. Methods This report compares COVID-19 mortality risk and comorbidity patterns among decedents with and without IDD using 2020 U. S. death certificate data. With or without IDD, the proportion of deaths from COVID-19 was also higher for decedents. During the first year of the pandemic, the COVID-19 mortality risk was higher for people with than without IDD.
Source link: https://europepmc.org/article/MED/PMC9450477
The presence of developmental delays in autism is well-established, but no research has reported heterogeneity in developmental milestone attainment in this population. The Autism Genetics Research Exchange, The Autism Simplex Collection, the Simons Simplex Collection, and the Simons Foundation Supporting Autism Research for Knowledge synchronized results from four cross-sectional autism cohorts, according to the study team. Participants Convenience sample of 21 243 autistic people or their siblings without an autism diagnosis aged 4 to 17 years. The research team conducted time-to-event experiments to determine and compare percentiles in time with milestone achievement among autistic people, subgroups of autistic people, and the sibling group. Autism was associated with the development of co-occurring ID, carrying an NDD-associated rare genetic variant, and being diagnosed with autism by age 5 years.
Source link: https://europepmc.org/article/MED/35849387
Objective Children with developmental disabilities are disproportionately at risk of poor school enrollment and educational achievement if timely and appropriate assistance are available. Epidemiologic evidence on cerebral palsy and associated comorbidities are lacking, as well as policies affecting global health. This paper sought to publish the best available data on cerebral palsy and developmental intellectual disability, as well as the associated "years lived with disability" among children under the age of 5 in 2019. 8. 1 million or 1. 2% of children under the age of 5 years are estimated to have CP, with 16. 1 million or 2. 4% experiencing intellectual disability. Both CP and intellectual impairment accounted for 6. 5% and 4. 5% of the aggregate YLDs from both causes of adverse health conditions respectively, with CP and intellectual disability accounting for 6. 55 percent and 4. 5 percent. The highest incidence of CP was found in the African region, while the South-East Asia region had the highest rate of mental disorder.
Source link: https://europepmc.org/article/MED/36091559
Adults with intellectual or developmental disabilities account for 1-2% of the population worldwide. Adults with IDD are also at a higher risk of neglect or mistreatment, according to a study that has been collected in multiple countries and in a variety of care settings. Practical and cost-effective interventions may address the identified inequalities and challenges facing the large population of adults with IDD. We recommend including a video into the evaluation of adults with IDD living outside the home to promote person-centered care, enhance record-keeping/documentation, and help with the security of this vulnerable group's health and safety.
Source link: https://europepmc.org/article/MED/36091544
We conducted whole-exon sequencing in all of available members from a large three-generation family to see if the YWHAZ gene played a role in intellectual disability and global developmental delay, and we discovered that a novel version of the YWHAZ gene was linked to intellectual disability and global developmental delay, according to the authors. We also performed computational modeling and knockdown/knockin with Drosophila to determine the role of the YWHAZ version in intellectual impairment. The c147A > T variation was a loss-of-function variant, according to computational simulations, as the ligand increased the binding energy in the mutated protein combining with the ligand. In YWHAZ c. 147A > T knockin flies, cognitive deficits and mushroom body morphological abnormalities were discovered. The YWHAZ knockdown flies also had serious cognitive disorders as a result of hyperactivity, which is consistent with the clinical findings. Our scientific and experimental findings all showed that YWHAZ was a novel intellectual disability pathogenic gene.
Source link: https://europepmc.org/article/MED/36001342
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