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Developmental Biology - PubMed

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Last Updated: 18 June 2022

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Resolving complex cartilage structures in developmental biology via deep learning-based automatic segmentation of X-ray computed microtomography images.

"We recommend a CNN-based segmentation scheme optimised for the large image size that we created using a unique manually annotated database. " The segmentation system was able to segment the cartilaginous nasal capsule with a median success of 84. 4 percent. From approximately 8 hours required for manual segmentation to mere 130 s per sample, the time needed for segmentation of new samples shortened from almost 8 hours to just 130 s per sample. "This will greatly expedite the throughput of u03bcCT analysis of cartilaginous skeletal elements in animal models of developmental diseases. ".

Source link: https://doi.org/10.1038/s41598-022-12329-8


Developmental biology is poised to discover altogether new principles in biology in the 21st century.

"Developmental biology pioneered a revolution in our knowledge of complex biological problems in the twentieth century. " But what will developmental biology do for this century? For example, single-cell RNAseq has reported novel, transient cell states in both stem and differentiated cells that are characterized by specific shifts in gene expression frequency during regeneration. These conditions, as well as our discipline's rich diversity of experimental and academic approaches, provide developmental biologists with unimaginable opportunities for developmental biologists not only to discover new biology but also to introduce completely new biology concepts. ".

Source link: https://doi.org/10.1016/j.ydbio.2022.05.004


Reflections on the past, present and future of developmental biology.

"Developmental Biology embodies some of biology's most fundamental questions and can trace its roots back to many thousands of years ago; the last 100 years have been particularly exciting. During the 100 years that some of our predecessors wrote some of the most important questions and a few key principles, as well as experimental design that can be used to find general rules governing cell behavior and choosing between various options, as well as methods of experimental design that can be used to uncover those rules even before we know their physicochemical underpinnings. ".

Source link: https://doi.org/10.1016/j.ydbio.2022.05.001


The role of cnidarian developmental biology in unraveling axis formation and Wnt signaling.

"Cnidaria are the sister group of the Bilateria, and their molecular toolkit is similar to that of more complex animals, making it unequivocally clear. " Molecular studies on cnidarian development have reported the presence of an ancient Wnt signaling center at the site of gastrulation, which was responsible for the establishment of a primary body axis and can be traced back to bilaterian and non-bilaterian animals. The molecular vectors for the dorso-ventral and left-right body axis in bilaterians, Bmp, and Nodal signaling, according to respective analyses, but in the two clades, the molecular vectors for the dorso-ventral and left-right body axes, respectively, were already present but in the two clades had different fates. The close association of developmental processes in bilaterians and cnidarians, as well as their distinct differences, make cnidarians an indispensable model for tackling fundamental questions of developmental biology, from patterning, regeneration, and other emerging molecular theories to theoretical models. ".

Source link: https://doi.org/10.1016/j.ydbio.2022.04.005


The Society for Craniofacial Genetics and Developmental Biology 44th Annual Meeting.

On October 18-19, 2021, the Society for Craniofacial Genetics and Developmental Biology held its 44th Annual Meeting in a virtual format" in a virtual format. " In Craniofacial Research Awards to Drs. Lars, the SCGDB Distinguished Scientists in Craniofacial Research Awards was awarded at the SCGDB. During craniofacial growth, craniofacial morphogenesis and reconstruction, translational craniofacial analysis, and signaling during craniofacial growth, four scientific sessions on craniofacial growth, craniofacial evolution, craniofacial origination and regeneration, craniofacial evolution and reconstruction, and morphogenesis and regeneration. Although the continuing COVID-19 pandemic resulted in a virtual meeting format for the second year in a row, the meeting platform provided ample opportunities for participant interactions and discussions, thus strengthening the community. ".

Source link: https://doi.org/10.1002/ajmg.a.62731


Synthetic developmental biology: Engineering approaches to guide multicellular organization.

"Organoids are in vitro 3D structures that represent key aspects of their in vivo counterparts' anatomy and physiology, as well as a self-organization process that arises from pluripotent or tissue-specific stem cells. " In the final section, we discuss how engineering tools may help with current organoid building constraints.

Source link: https://doi.org/10.1016/j.stemcr.2022.02.004

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions