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Dermatitis - DOAJ

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Last Updated: 23 July 2022

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Galectin-9 contributes to the pathogenesis of atopic dermatitis via T cell immunoglobulin mucin-3

paraphrasedoutput:MethodsObjectives We investigated the expression of TIM-3 and Gal-9 in 30 AD patients to compare them to those of 30 healthy controls and investigate potential correlations with disease characteristics such as AD prevalence, IgE levels, and circulating eosinophils and B cells. The AD patients' serum Gal-9 and circulating TIM-3-expressing cells had noticeably higher concentrations of serum Gal-9 and circulating TIM-3-expressing T cells than HC. We also investigated the effects of Gal-9 on T cells from the AD patients. The prevalence of circulating TIM-3-positive CD4+ cells was positively correlated with TH2/TH22 cells' incidences and were negatively correlated with TH2/TH17 cell growth.

Source link: https://doi.org/10.3389/fimmu.2022.952338


Autoimmune progesterone dermatitis: a retrospective case series

Autoimmune progesterone dermatitis is a rare hypersensitivity disorder in women that is characterized by recurring dermatologic manifestations during the luteal phase of the menstrual cycle. Thirteen patients were included in the mean age of clinical onset of 34. 3 u00b1 7. 7 years. Between the onset of disease signs and diagnosis, a 5. 5-year delay existed. In 9 of 14 patients, the onset of APD was due to exogenous progesterone. In 9 patients, the Progesterone skin test was positive, and six of them were negative. Patients were frequently diagnosed with urticaria and dermatitis.

Source link: https://doi.org/10.1097/JW9.0000000000000009


Recent insights into the management of treatment-resistant pediatric atopic dermatitis

About 12% of children worldwide, Atopic dermatitis is a common chronic inflammatory skin disorder affecting approximately 12% of infants. Pediatric AD patients have traditionally been treated with topical drugs, such as pharmacologic and nonpharmacologic administration, and off-label systemic drugs. To minimize comorbidities, sleep disturbances, pruritus, and signs of inflammation, as well as raise the patient's quality of life, it is important to ensure optimal AD treatment in pediatric patients. If these elements are removed, a skin biopsy is required to rule out other AD-like cutaneous disorders. Although the majority of patients improves with this therapy, some do not respond well.

Source link: https://doi.org/10.1097/JW9.0000000000000023


Proof of an optimized salicylic acid paste-based treatment concept of ulcerative M2-stage digital dermatitis lesions in 21 dairy cows.

Combining clinical and histopathological findings with molecular biological methods was used to determine the use of salicylic acid paste in the treatment of ulcerative bovine digital dermatitis. Treponema spp were found positive for Treponema spp. Pretreatment biopsy samples were followed by povidone-iodine ointment under bandage for one week before the administration of SA paste was administered. The outermost layers of the stratum corneum were only positive by Treponema-specific FISH, with only 3/26 biopsies isolated from previously contaminated sites proving positive by Treponema PCR and another biopsy. This is the first research on blinded molecular biological surveillance of SA's therapeutic performance with regard to treponemal disease in viva infants treated by SA treatment according to an optimized protocol. Although BDD's pathogenesis is considered multifactorial, our findings further back the assertion that treponemes play a central role in BDD pathogenesis.

Source link: https://doi.org/10.1371/journal.pone.0269521


Epigenetic and transcriptional dysregulation in CD4+ T cells in patients with atopic dermatitis.

Atopic dermatitis is one of the most common skin disorders among children. Disease etiology is a result of genetic and environmental factors, with 29 independent AD risk loci enriched for risk allele-dependent gene expression in the skin and CD4+ T cell compartments. We measured chromatin accessibility, nuclear factor kappa B subunit 1 binding, and gene expression levels in activated CD4+ T cells from patients with acute moderate-to-severe AD as well as age-matched non-allergic controls in order to determine the differences in gene transcription activity in peripheral blood T cells in AD. The increased CD4+ T cells of enriched AD genetic risk variants were significantly enriched for AD genetic risk variants, with almost half of the AD risk loci overlapping AD-dependent ATAC-seq peaks. Surprisingly, control-specific NFKB1 ChIP-seq peaks were not enriched for NFKB1 motifs, but rather displayed motifs for other classes of human transcription factors, indicating a mechanism that alters indirect NFKB1 binding.

Source link: https://doi.org/10.1371/journal.pgen.1009973


Safety Profile and Tolerability of Topical Phosphodiesterase 4 Inhibitors for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis

In published studies, ABSTRACT: Objective: Determine the safety profile and tolerability of topical phosphodiesterase 4 inhibitors versus vehicle as treatment for atopic dermatitis. PDE4 inhibitor treatment did not differ from vehicle treatment in global care emergent adverse events or in significant emergent adverse events reported in global reports. In PDE4 inhibitors with a low risk of bias, a reduced risk of dermatitis exacerbation was found in PDE4 inhibitors in comparison to the vehicle and the danger of pain at the application site was reported. PDE4 inhibitors did not differ from vehicle therapy in clinical emergent adverse events or severe emergent adverse events. PDE4 inhibitors had a statistically significant risk of producing pain and reduced the incidence of atopic dermatitis exacerbation in studies without a risk of bias.

Source link: https://doi.org/10.1016/j.curtheres.2022.100679


Improving Recovery of Irritant Hand Dermatitis in Healthcare Workers With Workplace Interventions During the COVID-19 Pandemic

The majority of occupational hand dermatitis is caused by frequent contact with hand hygiene products, and it is mainly due to frequent contact with hand hygiene products. During the COVID-19 pandemic. MethodsA quality enhancement program, a Tertiary Hospital's Plan-Do-Act model was used to identify and implement appropriate workplace interventions to assist in the recovery of occupational irritant hand dermatitis among healthcare workers. For the first time for likely occupational irritant dermatitis in the project, healthcare professionals seen at the Occupational Dermatology Clinic from March 2020 to May 2021. Organizations with high hand hygiene training or high rates of hand dermatitis may choose to implement systematic workplace reforms.

Source link: https://doi.org/10.3389/fpubh.2022.844269


The role of nurses in the management of atopic dermatitis: Results of an international survey

Abstract Background Atopic dermatitis is a chronic skin disease that has a major effect on patient quality of life and families' families. All patients with this disorder are recommended for therapeutic patient education in order to improve disease control, adherence to drugs, and quality of life. The aim of this study was to investigate the role of nurses in the care of patients with atopic dermatitis. Methods of Assessment A global survey was conducted to find the current role of nurses in TPE for patients with AD. In total, 85 health care professionals from 20 countries responded to the questionnaire. According to caregivers, a certified nurse may be able to assist in many other fields, including nurse consultations, patient care demonstrations, telephone follow-ups of consultations, and patient workshops. TPE in the field of AD is very promising for TPE because of their ability to enhance patient care.

Source link: https://doi.org/10.1002/jvc2.28


Expression of Staphylococcus aureus Virulence Factors in Atopic Dermatitis

Atopic dermatitis is a skin inflammatory disease in which the opportunistic pathogen Staphylococcus aureus is widespread and widespread. S. aureus has several unexplained virulence factors that have well-studied roles in infection models, but it is uncertain if these extracellular microbial factors are relevant in the context of AD. We used RNase-Hu2012dependent multiplex PCR for preamplification of reverse-transcribed RNA extracted from tape strips of patients with AD sampled at skin sites of varying severity and determining the presence of a panel of S. aurum virulence factors using qPCR. On sites with elevated incidence of disease, we noticed an increase in healthy S. aureus populations, and several virulence factors were present at the AD skin sites. Overall, we used a robust assay to rapidly detect and quantify viable S. aureus and its associated virulence factors at the site of AD skin lesions.

Source link: https://doi.org/10.1016/j.xjidi.2022.100130


Identification of Effective Diagnostic Biomarkers and Immune Cell Infiltration in Atopic Dermatitis by Comprehensive Bioinformatics Analysis

Methods: The GSE6012, GSE32924, and GSE36842 gene expression profiles were downloaded for analysis from the Gene Expression Omnibus database, which should help identify AD diagnostic and therapeutic biomarkers as well as provide insight into immune mechanisms at the molecular level by bioinformatics analysis. To search for module genes with AD characteristics, a weighted gene co-expression network analysis was conducted. The CIBERSORT algorithm was used to analyze skin samples obtained from AD patient healthy controls and lesions to determine the presence of immune cell infiltration. Results: Using Pearson correlation analysis, a total of 259 DEGs were obtained from the intersection of DEGs obtained by the two independent procedures, and 331 AD-trait module genes were separated out from the blue module by WGCNA testing. In the type I interferon and IL-17 signal transduction pathways, we discovered that co-DEGs were significantly enhanced. Between AD patients and HCs, we also found four significant difference immune cells, e. g. , stimulated dendritic cells, resting mast cells, and CD4+ nau00efve T cells. In addition, the relationship between the identified hub genes and key differential immune cells was investigated. Conclusion: The CCR7, CXCL10, IRF7, MMP1, and RRM2 were all positively correlated with the number of CD4+ nau00efve T cells, according to the results. AD has been a promising diagnostic and therapeutic biomarker for AD. The number of CD4+ nau00efve T cells in AD was positively correlated with the number of CD4+ nau00efve T cells, which was positively correlated with the number of CD4+ nau00efve T cells.

Source link: https://doi.org/10.3389/fmolb.2022.917077

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions