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Dermatitis - Crossref

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Last Updated: 23 July 2022

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Clinical efficacy of membrane-free stem cell extracts for the treatment of canine atopic dermatitis

The results of a membrane-free stem cell extract on atopic dog's clinical characteristics were examined in this study. Client-owned dogs previously diagnosed with cAD were divided into placebo and MFSCE-treated groups. MFSCE-treated patients had markedly reduced incidence of urinartus on day 14 compared to those on day 0. MFSCE-treated groups showed significantly reduced risk of pruritus on day 14 relative to that on day 0. In addition, the erythema, pigmentation, skin dryness, and thickness were dramatically reduced in the MFSCE-treated group on day 14 relative to those on day 0, although no significant changes were observed in the placebo-treated group. MFSCE may be a novel treatment approach for cAD, according to these findings.

Source link: https://doi.org/10.17221/136/2021-vetmed


Feasibility of a Digital Therapeutic for Atopic Dermatitis: Analysis of Engagement, Retention and Acceptability (Preprint)

BACKGROUND Patients with Atopic Dermatitis chronic eczema have chronic lesions, urinartus, sleep disorders, panic, and other health problems that affect their quality of life. In the long-term management of AD, current medications aim to improve these symptoms and reduce inflammation, but inadequate treatment adherence and disease recognition are key issues. OBJECTIVE We wanted to see the results of a digital therapeutic intervention tailored for AD via program engagement, retention, and acceptance. Adults with AD were recruited in Iceland for a six-week digital intervention delivered via a smartphone app. The education, drug recalls, and PROs all had high customer satisfaction and retention; all users who were introduced to the QoL PROs interacted with them; and 20/2021 users continued to participate in the education missions, medication missions, and symptom PROs. The step counter and mind missions among exposed users was lower, but exposed customers' engagement with the step counter and mind missions was still lower. All assigned users completed AD symptom PROs on weeks 1-5 on week 1-5, but just one did not do so on week 6; the total number and severity of AD symptoms improved during the program. CONCLUSIONS We found high satisfaction and retention in a targeted digital therapeutic program among patients with AD, as well as high compliance with missions related to medication reminders, patient education, and PROs. According to our conclusion, a digital therapeutic intervention is safe and could provide additional benefits to AD patients, including the monitoring and enhancement of AD symptoms.

Source link: https://doi.org/10.2196/preprints.41227


Molar-Incisor Hypomineralization: Positive Correlation with Atopic Dermatitis and Food Allergies

Aim: Molar-incisor hypomineralization is a disorder of dental growth that involves first permanent molars as well as permanent incisors with a prevalence ranging from 2. 5 percent to 40%. In the province of Barcelona, Spain, the aim of this study was to determine the etiology of molar-incisor hypomineralization in schoolchildren from two randomly selected towns. In 22 boys and 34 girls, there were a total of 56 cases of molar-incisor hypomineralization. Conclusions: For the first time, the present study reveals a statistically significant association between atopic dermatitis and food allergies as a result of molar-incisor hypomineralization.

Source link: https://doi.org/10.17796/1053-4625-42.5.4


Peran Probiotik sebagai Pencegahan Dermatitis Atopi

Dermatitis atopi merupakan kelit yang bersifat kronik dan residif, with a kerupakan yang bersifat korong dan residif. DA umumnya muncul pertama kali pada tahun pertama kehidupan pertama hidupan. Penelitian terbaru menunjukkan terutama strain bakteri campuran, sangat pengobatan pencegahan DA, pengobitan pengobatan dan pencegahan DA. Atopic dermatitis is a chronic and recurrent inflammatory skin disease. AD symptoms first appear in the first year of life. Probiotics, particularly mixed bacterial strains, have been shown to be very effective as a treatment and prevention of AD.

Source link: https://doi.org/10.55175/cdk.v48i1.1267


Fractional Exhaled Nitric Oxide in Teenagers and Adults with Atopic Dermatitis

A non-invasive biomarker of eosinophilic airway inflammation and therapeutic response to corticosteroid therapy of respiratory diseases is Fractional exhaled nitric oxide. Patients with AD were statistically significantly higher in patients with AD than in healthy controls, according to FeNO. We discovered a strong positive significant correlation between FeNO and the number of positive skin prick tests among AD patients. The presence of AD and a rise in positive skin prick tests raise FeNO, but the results of this analysis should be treated with caution in patients with respiratory disease related to AD.

Source link: https://doi.org/10.3390/arm90040033


Potential Natural Biomolecules Targeting JAK/STAT/SOCS Signaling in the Management of Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory skin disease attributed to the dysregulation of cytokines and other immune mediators. IL-4, IL-13, IL-31, and TSLP inhibits the production of essential skin barrier proteins and promotes pruritus in AD. The production of SOCS proteins regulates the JAK-mediated cytokines in JAK-mediated cytokines and aids in retaining AD's skin barrier disorder. STATs are vital in dendritic-cell-initiated Th2 cell differentiation in the skin, releasing inflammatory cytokines, meaning that AD is a Th2-mediated skin disease. Reduced Th1/Th2 cells and, in turn, regulate Th2-mediated allergic responses by reducing Th2/Th2 cells activation and differentiation. We focused on the existing literature on potential JAK/STAT/SOCS signaling, mostly emphasizing the SOCS family of proteins as negative regulators in modulating JAK/STAT-mediated responses in AD pathogenesis and other inflammatory disorders.

Source link: https://doi.org/10.3390/molecules27144660


Pterostilbene Attenuates Hexavalent Chromium-Induced Allergic Contact Dermatitis by Preventing Cell Apoptosis and Inhibiting IL-1β-Related NLRP3 Inflammasome Activation

Hexavalent chromium is widely used in many industries, but contact dermatitis, particularly in cement industries, can be present. Many cement workers are allergic to Cr-generated allergic contact dermatitis, and prevention and therapeutic measures are still lacking. In the epidermis, the level of increase following Cr treatment was found in mice's ear skin, as well as the pro-inflammatory cytokines, TNF-u03b1 and IL-1u03b2, which were found in mice's skin, which led to cutaneous inflammation, which was reported in mouse ear skin and IL-1u03b2. Meanwhile, the findings of our in vitro experiment showed that apoptosis and endoplasmic reticulum stress were induced after treatment with different amounts of Cr in HaCaT cells. Notably, the severity of the skin reactions in the epicutaneous elicitation test had significantly decreased when the mouse was treated with PT. In vitro, PT intervention improved HaCaT cells' inflammation and apoptosis.

Source link: https://doi.org/10.3390/jcm7120489


Savior in Desperate Situation: Successful TAVI for Critically Ill Patient with Severe Aortic Stenosis and Concomitant Constrictive Pericarditis Accompanied by Radiation Dermatitis, Complicated by Cold Abscess in Anterior Chest Wall

Convenient pericarditis can coexist with severe aortic stenosis, particularly in patients with recent mediastinal radiotherapy. Because impaired diastolic filling by CP may contribute to dangerous AS syndrome with low cardiac function, concomitant AS and CP result in a significant debilitating condition and pose a challenge to therapy. Case Report: A 79-year-old woman was admitted to our hospital with severe hypopnea and severe frailty. She had a history of persistent constrictive pericarditis, acute aortic fibrillation, diabetes mellitus, and radiation dermatitis complicated by a cold absces in the anterior chest wall from previous mediastinal radiation. We now have opted for palliative therapy for CP after undergoing transcatheter aortic valve implantation for severe AS.

Source link: https://doi.org/10.1532/hsf.2943


Stem Cells from Human Exfoliated Deciduous Teeth Attenuate Atopic Dermatitis Symptoms in Mice through Modulating Immune Balance and Skin Barrier Function

Atopic dermatitis (autoimmune disease) is a chronic skin inflammatory disorder that causes immune abnormalities and impaired skin barrier function. Mesenchymal stem cells have been suggested as an alternative therapeutic therapy for AD. Human exfoliated deciduous teeth stem cell cells form a special postnatal stem cell population with high immunomodulatory activity. Skin tissue cytokine mRNA levels and serum cytokine protein levels were investigated further. In conclusion, SHEDs reduced AD-like skin lesions in mice by altering the immune balance and skin barrier function. SHEDs can be a potential new treatment agent for AD.

Source link: https://doi.org/10.1155/2022/6206883


Assessment of the severity of atopic dermatitis — SCORAD and EASI

Atopic dermatitis is one of the most common chronic inflammatory skin diseases, and it can greatly influence the patient's quality of life. Heterogeneous medical signs with varying severity make it difficult to determine the severity of atopic dermatitis. The most basic and reliable methods for determining the severity of atopic dermatitis are SCORAD, oSCORAD, and EASI.

Source link: https://doi.org/10.25208/vdv1335

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions