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Deposition - BioProject

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Last Updated: 03 July 2022

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Transcriptome Sequencing to Identify Important Genes and lncRNAs Regulating Abdominal Fat Deposition in Ducks

Genes and lncRNAs were discovered in 304 Cherry Valley and Runzhou Crested White ducks, which were used to determine genes and lncRNAs that influence abdominal fat deposition. RNA sequencing was used to determine abdominal fat tissue of four ducks with respective high or low abdominal fat levels. The target gene prediction of differentially expressed lncRNAs was found in 602 genes that were further subjected to Gene Ontology and KEGG pathway analysis. Overall design: The deposition of bowel fats and the feed conversion ratio influence duck meat's quality and the feed conversion ratio. Here, we conducted transcriptome sequencing of ducks with elevated and low abdominal fat rate by RNA sequencing, finding the key regulatory genes and lncRNAs related to abdominal fat deposition.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/838584


Transcriptomics-based study of differentially expressed genes related to fat deposition in Tibetan and Yorkshire pigs

One of the key factors in pig production and breeding is fat deposition traits. The quality of pork and pig production is largely affected by the pig's fat deposition capacity. The aim of this research was to investigate differences in mRNA expression in Tibetan and York pigs' dorsal adipose tissue at different growth stages using transcriptomic data to identify key genes that control fat deposition in pigs. The results revealed that ACACA, SLC2A4 and THRSP genes positively regulated the lipid deposition capacity in pigs, while the CHPT1 gene negatively limited the lipid deposition ability.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/832663


De novo deposition of the histone H3 variants H3.1 and H3.3 during DNA replication

During the S phase, we developed a new sequence assay to track the de novo deposition of the histone H3 variants H3. 1 and H3. 3. We could also distinguish H3. 1 and H3. 3 dynamics from an early to mid-S phase at genome-wide resolution. We used HIRA knockout and control cells, and compared H3. 1 and H3. 3 distribution to early replication patterns identified by EdU labeling and sequencing nascent DNA.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/822201


H3K56 deacetylation and H2A.Z deposition are required for aberrant heterochromatin spreading

Interestingly, the dmm-1KO strain's persistent spreading of the 5-kb heterochromatin domain has been followed by histone variant H2A. Z's deposition and deletion of H2A. Z's chrochromatin domain, as well as the rapid propagation of the 5-kb heterochromatin domain into adjacent euchromatin. Moreover, lysine 56 of histone H3 is deacetylated in the expanded heterochromatin regions, and mimicking H3K56 acetylation with an H3K56Q mutation effectively stops H2A. Z-mediated heterochromatin traffic propagation of the 5-kb heterochromatin region. Overall plan: Dissecting the molecular causes of ectopic heterochromatin spreading in N. crassa.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/794749


H3K56 deacetylation and H2A.Z deposition are required for aberrant heterochromatin spreading

To discourage euchromatic gene silencing, heterochromatin's self-propagating nature makes it difficult to limit heterochromatin spreading within predefined boundaries. The JmjC domain protein METHYLATION MODULATOR-1 prevents aberrant heterochromatin transmission in the filamentous fungus Neurospora crassa, but exact details are uncertain. In the persistent dissemination of heterochromatin, gene-wide analyses revealed the general roles of H3K56 deacetylation and H2A. Z deposition in the aberrant dissemination of heterochromatin.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/792447


ATF7ip targets transposable elements for H3K9me3 deposition to modify CD8+ T cell effector and memory responses [ChIP-seq]

Mice with a T cell specific deletion of ATF7ip have a CD8+ T cell specific increase in Il7r expression and Il2 expression leading to enhanced memory responses. ATF7ip has been identified as an inhibitor of Il7r and Il2 gene expression in the Il7r gene loci and the Il21 intergenic area by ChIP-seq studies, who discovered it as an inhibitor of Il7r and Il2 gene expression by the deposition of the repressive histone marker H3K9me3 in the Il7r gene loci and Il21 intergenic region. In duplicate CD8Cre/ATF7ipfl/fl na00efve T cells were isolated by flow cytometry and H3K9me3 ChIP-seq, na00efve CD8 T cells were isolated by flow cytometry and Ha3K9me3 ChIP-seq, a k9me3 ChIP-seq and flow cytometry, nau00efve T cells were isolated T cells in na naeft T cells naefl vs CD8Cre/ATF7ipfl cytometry and ChIP-sefl cytometry and ChIP-Sefefl na nah na cytometry and ChIP-sefl nau00efefl nau00efl na nau00efl na/fl nau00efl na/h3-efl v.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/787789


HapX-mediated H2B deub1 and SreA-mediated H2A.Z deposition coordinate in fungal iron homeostasis during infection

FgSreA inhibits iron acquisition genes by facilitating the deposition of histone variant H2A. Z and histone 3 lysine 27 trimethylation at the first nucleosome after transcription start site suffers iron overload. Our results reveal the molecular mechanisms of adapting iron overload mediated by FgHapX and FgSreA during infection in F. graminearum, giving a new insight into epigenetic regulation of iron homeostasis in eukaryotes.

Source link: https://www.ncbi.nlm.nih.gov/bioproject/786942

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions