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Both understanding protein function and drug design are important for understanding protein function and drug design. Accurate identification of DNA-binding proteins is vital for both protein function and drug design. As experimental discovery of DBPs is time-consuming and often biased toward prediction, developing an accurate DBP model is a pressing need, and computational methods that can accurately forecast future DBPs based on sequence data are highly desirable. Using a convolutional neural network framework, a novel predictor called DeepDNAbP has been able to accurately predict DBPs from sequences. To display protein sequence diagrams, we use three feature extraction techniques, including position-specific scoring matrix, pseudo-amino acid composition, and tripeptide composition. Finally, the best features are added to the CNN classifier's ability to create the DeepDNAbP model for identifying DBPs. The final DeepDNAbP predictor achieves superior prediction results in K-fold cross-validation experiments and outperforms other commonly used predictors of DNA-protein binding methods.
Source link: https://doi.org/10.1016/j.compbiomed.2022.105433
In bupivacaine-induced neurotoxicity, the study sought to determine the biological function of p53 protein and long non-coding RNA taurine upregulated gene 1 in the study. TUG1, -H2AX protein expression, and TUG1 in vivo studies. The results revealed that bup could have dramatically reduced cell viability, increased cell viability, increased p53 mRNA and protein expression, as well as DNA damage, according to the researchers. In addition, in vitro experiment, intrathecal injection of p53 protein, TUG1, and -H2AX protein in the murine DRG was a transcription factor of TUG1, and a transcription factor of TUG1. P53 and TUG1 were found to promote DNA damage caused by bup in murine dorsal root ganglion cells, indicating a new approach for the prevention of bup-induced neurotoxicity in this study.
Source link: https://doi.org/10.1080/21655979.2022.2048985
Feeding is the only reliable diagnostic test for an adverse food reaction in dogs and cats, according to an elimination diet alone. Using polymerase chain reaction technology, the goal of the new study was to determine the presence of approved and undeclared mammalian deoxyribonucleic acid in commercially available canine treats and supplements. The DNA of ten mammalian species was tested in eight treat products and 20 supplement products. The most common, undeclared pig and cow DNA were the most popular, although there were only two instances of negative results for declared species.
Source link: https://doi.org/10.5326/JAAHA-MS-7143
Benzene is a carcinogenic chemical compound that causes injury and harm in DNA and its destruction by generating the free radicals in DNA. The antioxidants are the antioxidants that minimize DNA damage by blocking DNA damage by inhibiting DNA. Among the employees at a petroleum products distribution center's loading platforms, this research was conducted with the intention of determining primary harm of DNA and presence of plasma oxidative stress markers. The exposure group included those with a history of benzene use, as well as the control group, which was made up of the individuals with no history of exposure to benzene. The previously reported results revealed a decrease in the TL, %DNA, and %TAC values among the workers who had already exposed to benzene, as well as a rise in the TD and TM values of the same group relative to the control non-exposed group.
Source link: https://doi.org/10.1007/s11356-022-19015-2
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