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Chronic kidney disease, as well as its common causes, are common risk factors for severe COVID-19 disease. We investigated whether the most common inherited cause of CKD, autosomal dominant polycystic kidney disease, is also a risk factor, according to the VA health system and VA COVID-19-shared resources. These results were similar to patients with other cystic kidney disorders and cystic liver disease. When compared to other cystic kidney diseases and cystic liver-only diseases, ADPKD was not a significant risk factor for any of the four findings in multivariable logistic regression studies. ADPKD did not appear to raise the risk for newly starting dialysis in comparison with other cystic kidney diseases and cystic liver disease disorders after testing for CKD. When compared to other cystic kidney and liver patients, ADPKD did not significantly improve major COVID-19 outcomes among veterans.
Source link: https://doi.org/10.1101/2020.11.25.20238675
Progressive renal cysts enlargement leading to chronic kidney disease and end-stage renal disease is the hallmark of Autosomal dominant polycystic kidney disease. After eight years of follow-up, a baseline height-adjusted total kidney volume was found in a previous Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease's study, where the disease's development was shown to be connected with CKD stage 3 development. After a median follow-up of 13 years, here we extended our research and discovered that baseline htTKV was a good, reliable predictor of CKD development in a multivariable logistic regression framework model. For stage 4, 1. 42 for stage 4, 1. 38 for stage 4, 1. 38 for stage 5, 1. 35 for stage 5 or ESRD, respectively, the odds ratio of reaching each CKD stage per 100 mL/m increase in htTKV was 1. 38 and 1. 35 for stage 4, 1. 38 for stage 4 and 1. 35 for stage 5 or ESRD. Hence, baseline total kidney volume and kidney growth are both highly associated with the onset of advanced stages of CKD.
Source link: https://doi.org/10.1016/j.kint.2017.09.027
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