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Dominant - Springer Nature

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Last Updated: 05 June 2022

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Health Assessment for Mountainous Rivers Based on Dominant Functions in the Huaijiu River, Beijing, China

"Assessing river health based on dominant functions is of utmost practical value to river management. " 60 investigated plots were surveyed in 2016 in Beijing's northern mountainous river, which is a typical mountainous river in northern Beijing, and a hierarchy-comprehensive analysis scheme was employed to determine the health status of various reaches in Beijing's northern mountainous rivers, and a hierarchy-comprehensive analysis system was used. The Huaijiu River could be divided into six categories, including natural reaches, near-natural reaches, artificial bank plant construction reaches, artificial bank decoration plant reaches, and artificial bank brick masonry reaches, depending on the degree of human influence. All plots in natural reaches, artificial bank plant reaches, and artificial bank ornamental plant reaches were either healthy, submerged, or marginally impaired, according to the authors. The study found a way to assess mountainous river health based on popular metrics, but it is not based solely on natural river functions.

Source link: https://doi.org/10.1007/s00267-022-01620-z


Clinical characterization of autosomal dominant retinitis pigmentosa with NRL mutation in a three-generation Japanese family

"Purpose Retinitis pigmentosa is a heterogeneous group of inherited retinal disorders. " The Japanese people have a rare form of AD-RP; it is a rare form of AD-RP. Case study An example of four patients from a Japanese family were sent to The Jikei University School of Medicine for medical and genetic testing. Degeneration of retinal vascular and peripheral retina in an age-dependent manner, according to a Fundus photograph. Hyper-autofluorescence within the macular was seen with marginal hypo-AF in younger patients and apparent hypo-AF in older patients, according to Fundus autofluorescence imaging. The length of the ellipsoid zone tended to be longer in younger patients than in older patients, according to Optical coherence tomography. Non-recordable rod and cone function in older patients and non-recordable rod and cone function with preserved cone function in younger patients were among the non-recordable rod and cone functions reported by full-field electroretinographic findings.

Source link: https://doi.org/10.1007/s10633-022-09874-y


SAF-A mutants disrupt chromatin structure through dominant negative effects on RNAs associated with chromatin

"SAF-A, also known as heterogenous nuclear protein U, is a common nuclear scaffold protein that has been implicated in XIST RNA localization to the inactive X-chromosome but has also reported to maintain open DNA packaging in euchromatin. SAF-A has an N-terminal DNA binding domain and a C-terminal RNA binding domain, and a common model has been that the protein provides a single-molecule bridge between XIST RNA and chromatin. Our findings show that SAF-A mutants contribute to significant changes to chromatin condensation by dominant negative effects on C_0T-1 RNA, as well as other nuclear scaffold factors. In comparison, depletion of SAF-A by RNA interference had no effect on C_0T-1 RNA, and did not cause similarly observed chromatin changes as did three different SAF-A mutations. ".

Source link: https://doi.org/10.1007/s00335-021-09935-8

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions