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In the first trimester, a deep-learning algorithm was designed and validated from fetal ultrasound images for the diagnosis of cystic hygromas. Methods Our first trimester ultrasound scans in Ontario, Canada, were examined at four first trimester ultrasound scans for a cystic hygroma between 11 and 14 weeks gestation. Images were divided by 75% of images used for model development and 25% for model validation. Images were collected using a DenseNet model and the ability of the trained model to correctly identify cases of cystic hygroma was assessed by determining sensitivity, specificity, and the area under the receiver-operating characteristic curve. Results The study contained 289 sagittal fetal ultrasound images;129 cystic hygroma cases; and 160 normal NT controls. Conclusions Our results show that deep-learning algorithms can provide high accuracy in diagnostic diagnosis of cystic hygroma in the first trimester, when compared to expert clinical testing.
Source link: https://doi.org/10.1371/journal.pone.0269323
Objects: To summarize our results with OK-432 in treating fetal cystic hygroma and chylothorax complex with nonimmune hydrops fetalis. OK-432 was injected into the fetal pleural cavity or fetal cystic hygroma. Patient 1: At Atlanta 29 weeks, a 23-year-old, gravida 2, 1, had a recurrent fetal chylothorax. Intrapleural OK-432 injection was administered twice at GA 33 and 34 weeks. At GA 17 weeks, a 26-year-old girl, gravida 2, 1, was discovered to have a cystic hygroma of her fetus. The tumour was removed at Georgia 23 weeks by an OK-432 injection. Chylothorax grew, and the baby was born by cesareans at GA 32 weeks. Conclusion: The combination of an antenatal OK-432 injection, maternal dietary change, serial thoracocentesis plus paracentesis, amnioreduction, and tocolysis all appeared to contribute to the success of antenatal therapy. Fetal pulmonary expansion can determine immediate neonatal survival.
Source link: https://doi.org/10.1159/000085092
Enlarged fetal cystic hygroma is known to cause life-threatening conditions such as fetal hydrops and neonatal respiratory difficulties. At 23 weeks of gestation, a 28-year-old Japanese woman, gravida 0, was diagnosed with fetal cystic hygroma. At 26 weeks, the cystic lesion showed acute enlargement and intrauterine sclerotherapy with OK-432. Cases of fetal cystic hygroma enlargement without other problems are considered good candidates for intrauterine therapy to avoid future complications.
Source link: https://doi.org/10.1159/000075149
A 36-year-old multiparous woman was diagnosed with suspected cystic hygroma at 25 weeks of gestation. Large multiple cysts were found throughout the fetal neck during ultrasonographic examination. Following the intrauterine intervention, the cysts shrank in size. OK-432, a safe and effective therapy for fetal cystic hygroma, was a safe and fast-acting therapy.
Source link: https://doi.org/10.1159/000073129
The aim is to determine the actual course and the long-term prognosis of cystic hygroma following live birth. Both the frequency of hydrops fetalis and the maximum size of the cyst were both highly related to poor prognosis. Of 5 live births, three cases with chromosomal or structural abnormalities were handicapped. Conclusions: Hydrops fetalis and cyst size are poor prognostic factors, so fetal chromosome and structural malformations should be factored in when determining long-term prognosis.
Source link: https://doi.org/10.1159/000053948
With the intention of establishing standards for intrauterine therapy for cystic hygroma, we will review our cases of fetal cystic hygroma and evaluate the prognostic factors. Patients and Methods: Thirty-one cases of fetal cystic hygroma were tracked by us from January 1988 to December 1997, and 21 cases were available for analysis. Under ultrasound guidance, we treated two cases of cystic hygroma fetalis in utero using OK-432 injection under ultrasound guidance. Cases of fetal death or early neonatal deaths have been found in either intrauterine fetal death or early perinatal neonatal death. Conclusions: The fetal cases of cystic hygroma with hydrops fetalis without chromosomal abnormalities or structural abnormalities are thought to be potential candidates for intrauterine therapy. Sclerotherapy using OK-432 has been shown to be a treatment option in select cases of fetal cystic hygroma, based on our clinical experience.
Source link: https://doi.org/10.1159/000053891
Study focusing on small studies or from several centers with limited ascertainment are generally based on small studies or from several centers with limited ascertainment. During the study period, over 110,000 pregnancies were delivered at our clinic, resulting in 410 cases of septated cystic hygroma diagnosed prior to 14 weeks' gestation. The overall survival rate in the case of euploid cystic hygroma without structural abnormalities was 84%. The initial diagnosis of unusual karyotype in the case of first-trimester septated cystic hygroma is primarily focused on the likelihood of an elevated risk of an abnormal karyotype, which occurs in 61% of cases. Our results indicate only a 13% risk of major fetal abnormalities, which is significantly less than previously expected. These results represent the first single-center study of first-trimester cystic hygroma with complete outcome information, which may be useful for contemporary patient counseling.
Source link: https://doi.org/10.1159/000519056
A giant cervical cystic hygroma in a newborn, OK-432, a lyophilized incubation mixture of group A Streptococcus pyogenes of human origin, was used as a sclerosant for the emergence of a massive cervical cystic hygroma. Conclusions: The leucocytosis, which is induced and stimulated by OK-432 may have elevated the lymphatic permeability. Although its localised inflammatory response was localised, Intralesional injection of OK-432 was a safe and effective therapy for cystic hygroma in this infant.
Source link: https://doi.org/10.1159/000020983
Objective: The aim of this research was to determine the incidence and causes of referrals for prenatally diagnosed Turner syndrome and cystic hygroma infections in prenatal cases performed between 1998 and 2007. Similarly, 23 Turner syndrome cases were also analyzed for referral reasons in pre-natal settings. In 11 cases, cystic hygroma, missed abortion in six cases, advanced maternal age in 5 cases, and positive screening test findings in 1 case were all typical. Conclusion: The present report reveals the value of cystic hygroma in prenatal diagnosis of Turner Syndrome and other aneuploidy.
Source link: https://doi.org/10.1159/000199869
Introduction: The authors investigated the prevalence of chromosomal abnormalities in subcutaneous oedema detected in the fetus by intrauterine ultrasonography. In 374 cases of nuchal oedema, the chromosomal examination was performed in the first trimester because of nuchal translucency, but in 254 cases in the second trimester due to nuchal thickening, it was not successful. Investigations of non-immune hydrops and cystic hygroma were separately investigated in Cystic hygroma cases, non-immune hydrops cases, and combined cases of non-immune hydrops and cystic hygroma were investigated separately. In 48. 15, 20, and 53. 8 percent in cystic hygroma, non-immune hydrops, and combined occurrence of non-immune hydrops and cystic hygroma, respectively, was discovered in 48. 15, 20, and 53. 8 percent. Discussion: It was important to distinguish nuchal oedema and cystic hygroma, as well as non-immune hydrops in the case of non-immune hydrops, so it was also vital to discuss cases with or without cystic hygroma separately. Non-immune hydrops with or without cystic hygroma were classified as separate groups during the investigations.
Source link: https://doi.org/10.1159/000201946
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