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Cyclophosphamide - Wiley Online Library

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Last Updated: 27 June 2022

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Durability of and role of AKT in FGF7p urothelial protection against cyclophosphamide

FGF7P is a protein that blocks urothelial apoptosis similar to full length FGF7, but the effects of FGF7p on urothelial repair are uncertain. Also, while downstream AKT activation of FGF7p was linked to anti-u2010apoptotic activities, we have not explicitly investigated the role of AKT in mediating the cytoprotection. In mediating FGF7p's cytoprotective effects, we wanted to investigate the effects of FGF7p on urothelial repair and the role of AKT signaling. We performed hematoxylin and eosin staining in FGF7p-treated mice 28 days after co-u2010administering a systemic AKT antagonist with FGF7p-24 h after cyclophosphamide. After cyclophosphamide, vehicle-u2010 treated mice had ectopic lactunal progenitor cell markers, while FGF7p had none 28 days after cyclophosphamide. In urothelium 24 hours after injury, the AKT inhibitor's main FGF7pu2010administration of an AKT inhibitor largely abrogated FGF7pu2010driven AKT inhibitor activation and cytoprotection.

Source link: https://onlinelibrary.wiley.com/doi/10.14814/phy2.15358


Shrimp peptide hydrolysate modulates the immune response in cyclophosphamide immunosuppressed mice model

In this research, shrimp peptide hydrolysate was intended to investigate its immunomodulatory effect against cyclophosphamide-induced immunosuppressed mice. The SPH effect was also investigated on murine macrophage. Moreover, the important result had been achieved with the upregulation of cytokines interferon-u20102 level, interleukinu20102 level, and simultaneously downregulation of key genes including interleukin 2010 and interleukinu201010. Additionally, SPH advances cellular immunity by enhancing the detection of immunoglobulin A and immunoglobulin M. These results support the fact that SPH is an excellent immunomodulatory agent capable of preventing immune system hypofunction.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jfbc.14251

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions