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Cyclophosphamide - Springer Nature

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Last Updated: 27 June 2022

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Low dosage use of cyclophosphamide improves the survival of patients with systemic lupus erythematosus

SLE patients and SLE patients (u2019 overall and cause-specific mortality) mortality are expected to investigate the effects of cyclophosphamide on organ function and SLE patients. Methods The CicleC prescription was obtained from the Jiangsu Lupus database, which was designed to gather medical information from SLE patients following their first admission in Jiangsu province, China, during 1999-2013. The Kaplanu2013Meier model was used to determine the effect of CYC on mortality in relation to organ involvement and non-involvement. Out of a total of 2446 SLE patients, 221 people were recorded. With an adjusted HR of 0. 7 percent compared to non-users, CYC users reduced overall mortality of SLE. SLE's mortality was reduced in subgroups, including female; SLEDAI's ranking u2265 15 group; and those with neuropsychiatric, renal, and hematologic involvements, as well as low serum C3. Conclusions Lower dosage use of CYC reduced the risk of total mortality of SLE in SLE.

Source link: https://doi.org/10.1007/s10067-022-06117-y


Alterations of inter-domain flexibility in actin monomers during cyclophosphamide treatment

Cyophosphamide is used in the medical setting as cytostatic, and it has been shown that the CP treatment modified the in vivo muscle filament system, as well as direct interactions with actin monomers. Ca2+-F actin's CP treatment shows the same stability as CP bound monomers but lacks the structural stability of the more flexible polymer. As a thermodynamic advantage for the synthesis of a multi-domain protein can be blocked by CP treatment, we can safely assume that the inter-domain linker of actin reduces the domain's stability, resulting in a more flexible and variable system.

Source link: https://doi.org/10.1007/s10973-021-11096-4


Reduced intensity versus non-myeloablative conditioning regimen for haploidentical transplantation and post-transplantation cyclophosphamide in complete remission acute myeloid leukemia: a study from the ALWP of the EBMT

Leukemia's acute myeloid leukemia remains unclear, according to the optimal conditioning program prior to haploidentical stem cell transplantation with post transplantation cyclophosphamide. Alternatively, a reduced intensity conditioning program combining thiotepa and reduced-dose busulfan with fludarabine can reduce AML relapse, which may reduce AML relapse. In two separate populations based on age, we retrospectively compared CyFluTBI vs. TBF in CR AML patients who underwent Haplo-SCT with PT-Cy. Younger patients appear to benefit from conditioning intensification from CyFluTBI to TBF regimens prior to PT-Cy Haplo-SCT for CR AML, while older ones do not.

Source link: https://doi.org/10.1038/s41409-022-01674-x


Post-transplant cyclophosphamide and sirolimus based graft-versus-host disease prophylaxis after allogeneic stem cell transplantation for acute myeloid leukemia

However, no research has published the safety of a GvHD prophylaxis with sirolimus in patients with acute myeloid leukemia. In three European centers between January 2017 and December 2020, we analyze the use of sirolimus in combination with PTCy, with or without mycophenolate mofetil, on 242 consecutive adult patients with AML undergoing a myeloablative first allo-HSCT from various donor sources.

Source link: https://doi.org/10.1038/s41409-022-01725-3

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions