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Cyclophosphamide - DOAJ

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Last Updated: 27 June 2022

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Immunomodulatory Effect of Ginsenoside Rb2 Against Cyclophosphamide-Induced Immunosuppression in Mice

Immunomodulatory activity against cyclophosphamide-induced immunosuppression is the aim of this investigation. In the spleen of CTX-injected animals, IL-4, SYK IL-2, TNF-u03b1, and IL-6 were all significantly raised by mRNA expression in IL-4, SYK, IL-2, TNF-u03b1, and IL-6. Rb2 had outstanding binding capabilities with IL-4, SYK, TNF, TNF, and IL-6, according to cellular docking findings, suggesting that the target protein may be closely related to Rb2's immunomodulatory function. ginsenoside Rb2 alone, as shown by the regulation of related cytokine and mRNA expression in CTX-induced immunosuppressed mice, raising the immune function that is reduced in immunosuppressed mice.

Source link: https://doi.org/10.3389/fphar.2022.927087


Revisited Cyclophosphamide in the Treatment of Lupus Nephritis

Lupus nephritis is the most common complication of systemic lupus erythematosus nephritis. The pathogenesis of LN is uncertain, and the majority of LN causes are respiratory deposition of circulating or/and in situ-formed immune complexes. Despite the introduction of new biological products, cyclophosphamide, an alkylating agent, is still the first-line drug widely used to treat patients with severe LN.

Source link: https://doi.org/10.1155/2022/8345737


Quantification of N, N’ N’’-triethylenethiophosphoramide, N, N’ N’’-triethylenephosphoramide, cyclophosphamide, and 4-hydroxy-cyclophosphamide in microvolume human plasma to support neonatal and pediatric drug studies

The alkylating agents used for a variety of chronic and non-malignant disorders are triethylenethiophosphate and cyclophosphamide. We wanted to establish assays to determine parent drug and metabolic concentrations in small volume plasma samples to help with pharmacokinetic studies of thiotepa and CP in children. The calibration ranges were 2. 5-2,000ng/mL for thiotepa and tepa, 20-10,000 ng/mL for CP and 20-5,000 ng/mL for 4OHCP; dilution quality for samples outside of the calibration range was confirmed by 10-fold dilution for CP/4OHCP; Plasma samples at room temperature were stable for at least 60 hours for thiotepa, six days for tepa, and 24 hours for CP and 4OHCP-SCZ. Plasma samples for thiotepa/tepa were stable after four freeze-thaw cycles, and CP/4OHCP-SCZ was stable after three freeze-thaw cycles.

Source link: https://doi.org/10.1016/j.jcoa.2022.100054


Modulating effects of a functional food containing Dendrobium officinale on immune response and gut microbiota in mice treated with cyclophosphamide

The State Administration for Market Regulation has approved the National Herbal Drink as a functional food for immune enhancement. In this study, the effects of NHD on Cyclophosphamide-induced immune regulation and gut microbiota dysregulation in mice were explored to determine whether immunosuppression attribution was due to a NHD-induced immune regulation. Our analysis revealed that CTX caused immune organ damage in immunosuppressed mice, with reduced serum immunoglobulins IgG, IgM, and complement C3 and bone marrow hematopoiesis, as well as changes in liver toxicity and shortened colonic length. In addition, it is notable that NHD can also aid intestinal pathology and increase the expression of intestinal tight junction proteins Occludin and Claudin-1 to restore intestinal barrier function. Following the NHD intervention, the number of the beneficial genus uncultured_bacterium_g_norank_norank_norank_norank___> increased at the species level, while the number of the toxic genus unclassified decreased.

Source link: https://doi.org/10.1016/j.jff.2022.105102


Altered Regional Brain Glucose Metabolism in Diffuse Large B-Cell Lymphoma Patients Treated With Cyclophosphamide, Epirubicin, Vincristine, and Prednisone: An Fluorodeoxyglucose Positron Emission Tomography Study of 205 Cases

Results: Compared to the controls, the post-chemotherapy group demonstrated increased metabolism in the right hippocampus and the left hippocampus, as well as reduced metabolism in the left medial orbitofrontal gyrus, the left medial superior frontal gyrus, and the left superior frontal gyrus. The number of chemotherapy cycles in certain brain regions, particularly in the bilateral frontal gyrus, was positively correlated with the regional brain glucose metabolism. ConclusionsThese two variables were positively related in several southwestern hippocampus areas, respectively. In other words, these two variables were positively related. These findings will help us gain insight into human brain function changes in post-chemotherapy DLBCL patients, and they indicate that 18F-FDG PET/CT scanning is a useful neuroimaging method for investigating chemotherapy-induced brain function changes.

Source link: https://doi.org/10.3389/fnins.2022.914556


Metronomic chemotherapy using oral cyclophosphamide and bevacizumab for recurrent cervical cancer: A multi-institutional retrospective study

Patients with recurrent cervical cancer are undergoing platinum chemotherapy, but no approved chemotherapy is available after disease progression or anaphylaxis during platinum chemotherapy. Here we detail the effectiveness and dangers of metronomic chemotherapy, which includes 50 mg of oral cyclophosphamide daily and intravenous 15 mg/kg of bevacizumab, which are repeated every three weeks. According to the Common Toxicity Criteria for Adverse Events ver 5. 0 and Response Evaluation Criteria In Solid Tumors ver 1. 1, respectively, adverse events and response rates were recorded during adverse events and reaction rates were recorded. Between 2016 and 2021, eleven patients had been treated with CPA-BEV, squamous cell carcinoma in seven patients, adenocarcinoma in three, and large cell neuroendocrine carcinoma in one of three. Four patients recurred within six months of the last platinum therapy, four patients recovered within six months, and one patient had platinum anaphylaxis.

Source link: https://doi.org/10.1016/j.gore.2022.101013


The NLRP3 Inflammasome Inhibitor Dapansutrile Attenuates Cyclophosphamide-Induced Interstitial Cystitis

Interstitial cystitis/bladder pain syndrome, also known as IC, is a medical disorder characterized by urinary inflammation in the bladder. Nonetheless, the impact of NLRP3 inhibitors, including dapansutrile, on IC had not been investigated previously. Mice treated with Dap improved UB pathology and reduced inflammation scores, as well as the number and number of mast cells and neutrophils, relative to mice that received CYP alone. As compared to CYP alone, the UB's infiltration of T cells in the spleen and iliac lymph nodes, as well as a drastic decrease in CXCR3+CD8+ T cells, as well as decreased levels of systemic proinflammatory cytokines.

Source link: https://doi.org/10.3389/fimmu.2022.903834


Tilapia Skin Peptides Ameliorate Cyclophosphamide-Induced Anxiety- and Depression-Like Behavior via Improving Oxidative Stress, Neuroinflammation, Neuron Apoptosis, and Neurogenesis in Mice

Following chemotherapy therapy, Anxiety- and depression-like behavior in cancer patients has been common, with high likelihood and no specific drugs available for diagnosis and prevention of this disorder. cyclophosphamide-induced anxiety and depression in mice were tested on tilapia skin peptides, a novel enzymatically hydrolyzed peptide mixture obtained from tilapia scraps. After the TSP therapy, abnormalities in behavioral tests were markedly improved. The expression of Iba-1 and the concentrations of TNF-u03b1 and IL-1u03b2 in mice's hippocampus has been normalized by TSP, which has shown that TSP could well as the hippocampus of mice, suggesting that TSP could even reduce neuroinflammatory response. In the TSP group vs. the Model group, the TSP ameliorated the apoptosis of hippocampal neurons of CA1 and CA3 regions. In mice versus. the Model group, the number of doublecortin positive cells was dramatically increased by administering 1000 mg/d TSP in mice.

Source link: https://doi.org/10.3389/fnut.2022.882175


Antigenotoxic Activity of Rumput Mutiara (Hedyotis corymbosa L.) Ethanolic Extract on Cyclophosphamide-Induced Mice

Rumput Mutiara or Hedyotis corymbosa L. 's ethanolic extract is reported to contain ursolic acid as a key component with antigenotoxic activity on HepG2 cells. This research investigates the antigenotoxic effects of HcEE on male Swiss mice by cyclophosphamide-induced males. The ursolic acid on HcEE was determined by thin layer chromatography with silica gel as the stationary phase and chloroform-aceton as the mobile phase. HcEE was found to be almost identical in hRF with the ursolic acid standard reference, which indicated that the extract did not entirely contain ursolic acid. HcEE reduced MNPCEs significantly compared to the CP group, while a combination of CP with HcEE demonstrated significant decreases in %PCEs. ursolic acid had lower docking scores than CP against CYP3A4 and a similar binding site on amino acid residues Ala 448, Ile 369, Thr 309, and Val 313. Based on molecular docking results, ursolic acid had a lower docking score than CP against CYP3A4 and a similar binding site on amino acid residues, comparing urolic acid residues Ala 448, Thr 369, Thr 369, Thr 369, based on based on CYP3A4 and CYP3A4 and phosphate binder phosphate 369, Thr 309, and Val 313.

Source link: https://doi.org/10.14499/indonesianjcanchemoprev8iss3pp135-145


Antigenotoxicity Activity of Papaya (Carica papaya L.) Leaf Ethanolic Extract on Swiss Mice Induced Cyclophosphamide through Mammalian In Vivo Micronucleus Test

Quercetin, a flavonoid compound, is identified on Papaya leaf. Hence, the aim of this study is to determine the antigenotoxic effect of ethanolic extract of papaya leaf on CPA-induced mice. At dose 1000 mg/kgBW, 500 mg/kgBW; and 1000 mg/kgBW; and 1000 mg/kgBW; and 1000 mg/kgBW. Compared to a single dose of CPA, the three different combination doses of EEPL with CPA greatly reduced the amount of micronucleated polychromatic erytrocyte erythrocyte and increased % PCE/. Quercetin has more potent interaction to CYP 3A4 than cyclophosphamide, according to the docking score results, and both of them have similar active sites at amino acid residue Ile 369 and Thr 309. By comparison of quercetin and CYP 3A4 based on molecular docking, the optimal dose as an antigenotoxic agent is found by the results.

Source link: https://doi.org/10.14499/indonesianjcanchemoprev7iss1pp31-37

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions