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Background: The aim of this review was to document all instances of acinic cell carcinoma associated with paraneoplastic ectopic Cushing's syndrome. AcCC was only present in the parotid, and primary care included surgical excision, neck dissection, and radiotherapy. CS-EAS was first diagnosed 6 months after AcCC care in four patients. Clinicians should be aware of this brisk presentation of Accute disease and should consider this diagnosis in patients with Cushingoid signs and symptoms.
Source link: https://doi.org/10.1016/j.adoms.2021.100236
Multiple endocrine and non-endocrine tumors, as well as multiple endocrine and non-endocrine tumors, are a rare condition. In this paper, we introduce a 23-year-old Iranian woman with CNC who had a novel mutation in the PRKAR1A gene that caused the deletion of a novel mutation in the PRKAR1A gene. The PRKAR1A gene was PCR amplified using genomic DNA and analyzed for sequence variants, revealing the novel mutation, which resulted in amino acid cysteine substitution instead of the naturally occurring vaping valine in the peptide chain and a premature stop codon at position 18, which resulted in a premature stop codon at position 18 and a premature stop codon at position 18.
Source link: https://doi.org/10.20945/2359-3997000000369
TXNIP in patients with endogenous Cushing's syndrome has increased bone expression in TXNIP, and we hypothesized that TXNIP may play a role in CS' dysregulated glucose metabolism. Our key findings were: The elevated mRNA levels of TXNIP in bone from CS patients were significantly related to elevated glucose and insulin resistance, elevated insulin resistance, and reduced insulin sensitivity in these patients. We recently reported that the thioredoxin/TXNIP axis could have some adverse effects of glucocorticoid excess on bone tissue in CS bone tissue.
Source link: https://doi.org/10.1371/journal.pone.0064247
In addition, Cushing's disease patients without cardiomyopathies were collected as controls to compare the clinical features. Results: A total of 19 cases of CS complicated by cardiomyopathies and cases of CD without cardiomyopathies were found in comparisons. In the serum cortisol concentration and 24-h urine free cortisol, there were no significant differences between the CS complicated with cardiomyopathies group and the CD patients without cardiomyopathies in the serum cortisol concentration and 24-h urine free cortisol, but there was no difference in the adotropic hormone level [109. 60 pg/ml]. After remission of hypercortisolemia after treatment with CS, patients with CS showed significant improvement or even complete recovery of the heart structure and function, and it can be greatly enhanced following the remission of hypercortisolemia.
Source link: https://doi.org/10.3389/fcvm.2021.777964
Canine Cushing's syndrome can be caused by a pituitary tumor or a cortisol-intisol-covered adrenocortical tumor. We selected a total of 20 miRNAs for the definitive research after a pilot study with 40 miRNAs in blood samples of healthy dogs, dogs with PDH, and dogs with a csACT. Six miRNAs were differentially expressed in dogs with PDH, compared to healthy dogs. MiR-141-3p was also significantly lower in dogs with csACTs with a histrecht score of 11 as compared to those with a score of 11. These findings show that circulating miRNAs have the capability to be non-invasive biomarkers in dogs with Cushing's syndrome, which may aid in clinical decision making.
Source link: https://doi.org/10.3389/fvets.2021.760487
As observed in premature aging, we speculated that an inflammatory state and elevated CVR in CS may be related to TL shortening. The TRF-Southern method was used to determine total white blood cell TL. Correlations were found between TL and clinical characteristics, and a multiline regression analysis was carried out to look at potential predictors of TL. Dyslipidemic CS had shorter TL than non-dyslipidemic ones, according to the study. Patients with cured and active CS dyslipidemic patients had shorter TL than non-dyslipidemic CS after adjustment for age and body mass index. In CS or in the control group, there was no difference in TL when other individual CVR factors were present. In dyslipidemic obese patients who were also hypertensive, as well as those with two or less CVR factors, additional TL shortening was observed. TL shortening and consequently to premature ageing and elevated morbidity in CS can be due to increased lipids and a "low" grade inflammation.
Source link: https://doi.org/10.1371/journal.pone.0120185
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