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Between 10% and 15% of patients with endogenous hypercortisolism have ectopic production of the adrenocorticotropin hormone that causes cortisol excess. Pathological tissue is detected by physiologic and biochemical reactions within the abnormal tissue, which is contrary to positron emission tomography and somatostatin ligand imaging. This protocol examines the ability of [18F]-L-3,4-dihydroxyphenylalanine PET and its somatostatin imaging analogue, 68Ga-DOTATATE-PET, to localize the source of ectopic ACTH production.
Source link: https://clinicaltrials.gov/ct2/show/NCT02019706
In 1% of patients under the age of 30, but in nearly 7% of patients older than 70 years, adrenal tumours appear in 1% of patients under the age of 30, but in around 7% of patients older than 70 years. However, most often adrenal incidentalomas are non-functional. In ten to ten percent of patients with adrenal incidentalomas, Cushing's syndrome is present in ten to five percent. After an overnight test with 1 mg of oral dexamethasone, the diagnosis is that the cortisol secretion is not limited. 8000 nmol / L at 8. 00, a 900. Patients with subcutaneous Cushing's syndrome are likely to have elevated blood pressure, diabetes, impaired glucose tolerance, and a poor DHEAS poor or supressed. In addition, numerous research has demonstrated that patients with subcutaneous Cushing's syndrome have elevated blood pressure, diabetes, impaired glucose tolerance, and poor DHEAS are common.
Source link: https://clinicaltrials.gov/ct2/show/NCT01246739
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