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Background Cryoglobulins are immunoglobulins that precipitate at low temperatures. In any laboratory that has a 37 °C incubator and temperature-controlled centrifuge, the first step of detection of cryoglobulins can be carried out. Characterization includes immunoglobulin typing for the determination of cryoglobulins and potential underlying disease; measurement of serum complement; and determination of serum complement, which is useful for diagnosis. Summary These practical guidelines will be helpful in the proper detection of cryoglobulins, an important first step in the diagnosis of cryoglobular vasculitis, a rare but severe clinical manifestation of cryoglobulins.
Source link: https://europepmc.org/article/MED/34718470
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