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Creatine - Springer Nature

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Last Updated: 19 June 2022

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An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors

"Several research has shown that mitochondrial creatine kinase 1A plays a key role in numerous cancer types in recent years. " However, there is also a lack of scientific evidence supporting CKMT1A's role in various types of cancer. Hence, this research seeks to investigate the potential role of CKMT1A in human tumors. We first reviewed the expression of CKMT1A in 33 forms of tumors. We explored the connection between CKMT1A expression and survival prognosis by using the GEPIA2 and Kaplanu2013Meier plotter in the tibia chapter. In addition, the cBioPortal web's genetic variations of CKMT1A were investigated. CKMT1A was highly expressed in several types of cancers, and there was a strong correlation between CKMT1A expression and patient prognosis for those tumors. A poorer overall survival was seen among non-Small Cell Lung Cancer patients with altered CKMT1A. In most tumors, the presence of cancer-associated fibroblasts was not positively related to the infiltration of cancer-associated fibroblasts. ".

Source link: https://doi.org/10.1038/s41598-022-14346-z


Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF

"As epileptic animal models have been shown to have elevated cerebral GAA levels, the processing system of GAA in the brain is critical for maintaining brain homeostasis. " We have confirmed that monocarboxylate transporter 12 functions as an efflux transporter of GAA and creatine, a precursor to GAA, in the kidneys and liver. MCT12-derived signals mixed with those of the marker protein at the apical membrane of CPxEpic's apical membrane, suggesting that MCT12 is localized on the apical membrane of CPxEpic's apical membrane. "The converting of creatine from CSF to bonechyma parenchyma was 4. 65 bb5L/, suggesting that biosynthesized creatine in CPxEpic is released into the CSF and delivered to the brain parenchyma. ".

Source link: https://doi.org/10.1186/s12987-022-00328-w


Creatine kinase and prognosis in amyotrophic lateral sclerosis: a literature review and multi-centre cohort analysis

"Background Amyotrophic lateral sclerosis is a prognostically heterogeneous neurodegenerative disease. " The blood creatine kinase level has been inconsistently reported as a prognostic biomarker, and elevated levels in some ALS patients have been reported as a muscle wasting biomarker, though muscle wasting is also variable. Methods MEDLINE was systematically searched for papers relating to CK in ALS, and the relevant studies were analyzed. Results Twenty-five studies into CK in ALS were identified, of which 10 specifically investigated the correlation between CK and survival, of which ten specifically investigated the connection between CK and survival. In males with limb versus bulbar onset of symptoms and patients with higher motor neuron burden were elevated relative to females. Although elevated CK values in ALS do reflect reduced motor neuron denervation to a large extent, they are not directly linked to survival when measured in the disease's symptomatic phase. ".

Source link: https://doi.org/10.1007/s00415-022-11195-8

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions