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"The present prospective cohort study was conducted to determine the effects of postoperative serum CPK as an indicator of muscle injury in connection with various spinal and nonspinal procedures. " Conclusions There was a significant dose-response correlation between the CPK ratio and surgical invasiveness; surgicallyinvasive surgery had the highest CPK ratio; minimally invasive surgery had the lowest CPK ratio; and surgically invasive surgery had the lowest CPK ratio. Compared to those for cervical and nonspinal surgery, Thoracolumbar surgery had a significantly higher CPK ratio. The CPK ratio in revision surgery was much higher than in primary surgery, with a higher CPK ratio significantly higher than in primary surgery. The CPK ratio for unilateral versus bilateral approaches were higher, while bilateral approaches were not significantly different. CPK levels in the early and preoperative serum levels had a significant effect on postoperative CPK. There was also a strong correlation between CPK ratio and nonspinal surgery.
Source link: https://doi.org/10.3171/spi-07/09/282
"Abstract Lung cancer is the leading cause of cancer-related death globally. " Tumor resection is the most commonly used therapy for stage I non-small cell lung cancer patients, and it can be followed by chemotherapy in patients with pathologically high-risk, margin-negative stage IB tumors. Therefore, biomarkers that molecularly classify stage I patients after tumor resection and stratify high-risk patients who may benefit from adjuvant chemotherapy may lead to improved clinical outcomes. In 48 NSCLC cases, creatine riboside levels were 19-fold higher in tumor tissues relative to similar lung tissues. We learned later that creatine riboside levels in tumor tissues correlate strongly with those in urine. These results indicate that creatine riboside can be a product of deregulated tumor metabolism that is detectable in urine, making urinary creatine riboside a potentially useful liquid biopsy biomarker for monitoring after surgery in early stage NCSLC patients. Urine samples from 34 stage I and II NSCLC patients from Lung Cancer Biospecimen Resource Network, which were collected at the time of diagnosis and 6, 12, 18 and 24 months after surgery, were used to analyze creatine riboside as a liquid biopsy biomarker. Ury creatine riboside has the potential as a liquid biopsy biomarker for early stage NSCLC that aids in monitoring after surgery as well as stratifying patients with poor prognosis. "abstract": Ury creatine riboside is used in early stage non-small cell lung cancer [abstract].
Source link: https://doi.org/10.1158/1557-3265.aacriaslc18-pr02
"Abstract This abstract is being presented as a short talk in the scientific program. " Ury creatine riboside has been used in early stage non-small cell lung cancer in diagnostic and prognostic role, according to the abbreviation [abstract]. In:: Proceedings of the Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic, Jan 8-11, 2018; San Diego, California; Jan 8-11, 2018.
Source link: https://doi.org/10.1158/1557-3265.aacriaslc18-a18
We reviewed the CK activity of 544 SMA patients in a collaborative research on all aspects of childhood and juvenile onset SMA. " The measurement of the means revealed no significant differences between early and late onset SMA: in SMA I and II, approximately one-third of patients had CK-SDS > 2 SD; in SMA I and II, about one-third of patients had CK-SDS> 2 SD. In SMA IIIa, more than 90% of SMA IIIb patients had CK-SDS values > 2 vs. 57%. Our findings are likely to be representative of SMA Iu2013III as similar results were obtained for a subset of 100 patients in whom the diagnosis of autosomal recessive SMA was confirmed by a deletion of the survival motor neuron gene can be found. The observed higher male figures in SMA IIIb are most likely due to a shortage of female patients with onset after puberty.
Source link: https://doi.org/10.1159/000007926
"Background: To investigate the effects of creatine and coenzyme Q10 combination therapy on mild cognitive impairment in Parkinson's disease and its effects on plasma phospholipid levels in PD-MCI. " The difference between the MoCA scores of the combined therapy and control groups was statistically significant, and the plasma PL levels of the combination therapy group were significantly lower than those of the control group after 12 and 18 months of therapy, and the control group's plasma PL levels were much lower than those of the control group. '.
Source link: https://doi.org/10.1159/000377676
"The CKB protein level was very low at postnatal day 1 and week 1" during rat brain cerebrum development, but by week 4 it had increased 6-fold and remained stable throughout week 10. CKB mRNA levels were maxim on day 1 and week 1, suggesting that CKB protein expression does not simply reflect the amounts of CKB mRNA and is likely restricted posttranscriptionally during early postnatal times. Low CKB protein levels at early postnatal times could be related to normal translation initiation of CKB mRNA, followed by an arrest during elongation or termination of CKB mRNA, followed by rapid degradation of CKB mRNA. CKB's apparent posttranscriptional control of CKB in early postnatal cerebrum contrasts with the transcriptional rule that restricts CKB protein synthesis in postnatal developmental cerebellum.
Source link: https://doi.org/10.1159/000075668
"We hypothesized that creatine supplementation could prolong energy metabolism and thus reduce energy loss and hence reduce the risk of brain edema in the neonatal rat model after persistent but transient cerebral hypoxia-ischemia. paraphrased artery ligation at P7 in a second group. P4 rats received the same Cr dose as above for three days before unilateral common carotid artery ligation followed 1 h later by 100 min of hypoxia at P7. As calculated from diffusion-weighted images, Rats with hemispheric cerebral hypoxic hypoxic-ischemic insult that had received Cr showed a significant decrease in the volume of edemmic brain tissue relative to controls. Since DWI has been shown to correlate with the PCr/Pi ratio in the acute phase of injury, we hypothesize that neuroprotection is likely due to the availability of a larger metabolic substrate pool leading to a decrease in the secondary energy loss.
Source link: https://doi.org/10.1159/000069043
"Between 5 and 30 days of age during normal growth, rabbit gray matter mitochondrial creatine kinase rises by 400%, while cytosolic CK rises by 60%. " In vivo CK rate constants measured by 31 P nuclear magnetic resonance increase 30% between 10 and 20 days, then decreased 50% between 20 and 30 days in mainly gray matter slices, and then fell 50% between 20 and 30 days. Thus, the biggest improvement in the CK system associated with the prevention of hypoxic seizures in Cr-treated rabbits is an increase in PCr in gray and white matter. ".
Source link: https://doi.org/10.1159/000017473
"Aim: To find out whether 4 months of rivastigmine therapy will result in metabolic changes and whether metabolic changes correlate with decline in cognition in people with Alzheimer's disease. " Methods: Until and four months after the treatment began, magnetic resonance imaging scans and cognitive evaluations were obtained from the posterior cingulate cortex of patients with AD at 3 T.
Source link: https://doi.org/10.1159/000367685
"The CK activity was noticeably reduced in AD, PkD, and DLBD patients, and CK BB-specific mRNA was significantly reduced in AD and DLBD. " Our results show that oxidative stress may play a role in the onset of frontal dysfunction in AD, PkD, and DLBD. The development of frontal dysfunction in idiopathic PD may be due to oxidative injury and neuronal loss, mostly located in the nigrostriatal system. The absence of the isoenzyme in various neurodegenerative diseases is most likely due to its posttranslational modification, perhaps oxidative damage. The results of CK BB expression analysis show that the absence of the isoenzyme in several neurodegenerative disorders is mainly due to its posttranslational modification, perhaps oxidative damage. Changes in CK BB expression may be a early sign of oxidative stress in neurons.
Source link: https://doi.org/10.1159/000017098
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